Results 61 to 70 of about 2,471,598 (337)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Orange emission in Pr3+-doped fluoroindate glasses [PDF]

open access: yes, 2012
We synthesize and study the properties of praseodymium doped fluoroindate glasses. Glass compositions with praseodymium molar concentrations up to 5% were obtained with good optical quality. Thermal, optical, and luminescence properties are investigated.
Adam   +36 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Une poursuite d’études accompagnée

open access: yesCahiers de la Recherche sur l'Education et les Savoirs, 2009
Higher Technicians Sections (STS) allow underclass families to stay into the educational system after Baccalauréat thanks to a new distribution of roles for school, students and their parents within higher education.
Sophie Orange
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Spécificité de la problématisation scientifique : le travail d’abstraction et de généralisation

open access: yesRecherches en Éducation, 2007
Dans notre souci de comprendre la problématisation scientifique, et en prolongement de la présentation au symposium « Probléma » de Chicoutimi, nous explorons ici une caractéristique fondamentale des problématisations théoriques (en sciences) : le ...
Christian Orange
doaj   +1 more source

A survey of epistemology and its implications on an organisational information and knowledge management model [PDF]

open access: yes, 2008
This is a theoretical paper which aims to integrate various epistemologies from the philosophical, knowledge management, cognitive science, and educational perspectives.
Kor, AL, Orange, G
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Apprentissages scientifiques : ce qui se construit et ce qui se transmet

open access: yesRecherches en Éducation, 2007
Nous discutons ici des relations entre construction (par les élèves) et transmission (par le professeur) dans les apprentissages scientifiques. Pour cela nous présentons trois cas où ces relations sont différentes.
Christian Orange
doaj   +1 more source

Home - About - Disclaimer - Privacy