Results 271 to 280 of about 9,997,733 (366)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Clinical profiling of TPOAb and TGAb in patients with thyrotrophin receptor antibody-negative thyroid eye disease: A single-center observational study in China. [PDF]

Front Endocrinol (Lausanne)
Jing G, Fu S, Yang X, Li Y, Ma R, Wu W, Tang X.   +6 more
europepmc   +1 more source

Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

Advanced Science, EarlyView.
This study proposes for the first time that hepatic GSDMD plays a key protective role in sepsis. Hepatic GSDMD may release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of septic mice ...
Yihan Qian, Bingrui Wang, Chang Yu, Yuge Zhou, Weifan Huang, Xing Rong, Yali Sang, Jiangang Song, Hailong Wu, Xiaoni Kong   +9 more
wiley   +1 more source

Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease. [PDF]

Discov Oncol
Tagami M, Isayama K, Nishio M, Yoshikawa A, Misawa N, Sakai A, Haruna Y, Tomita M, Mizukami Y, Azumi A, Honda S.   +10 more
europepmc   +1 more source

ORBITAL MANIFESTATIONS OF SINUS DISEASE

, 2015
T. Jyothirmayi, V. S. Meenakshi, M G Deepika   +2 more
openalex   +1 more source

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

Six-Year Remission With No Relapse After Four-Time Weekly Rituximab Only for Bilateral Ocular Adnexal Follicular Lymphoma. [PDF]

Cureus
Matsuo T, Tanaka T, Fujii N.
europepmc   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

Invasive Aspergillosis with Intracranial Extension Initially Misdiagnosed as a Granulomatous Disease: A Case Report. [PDF]

J Fungi (Basel)
Asahi K.
europepmc   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

Advanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong, Shuguang Yang, Xiao Li, Zhuang Jin, Jianyu Ma, Zhouzhou Liao, Jinbo Li, Bo Li, Xintao Shuai, Shuqin Chen   +9 more
wiley   +1 more source