Results 101 to 110 of about 619,936 (293)

Exponential Convergence Analysis of Serial Differentiators for Robust and Accurate Estimation of High-Order Derivatives

IEEE Access
This paper presents a rigorous mathematical analysis of the higher-order serial differentiator (HOSD), originally proposed by the authors for estimating time derivatives of time-varying signals.
Jang-Hyun Park, Dong-Ho Lee
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Estimating a convex function in nonparametric regression [PDF]

A new nonparametric estimate of a convex regression function is proposed and its stochastic properties are studied. The method starts with an unconstrained estimate of the derivative of the regression function, which is firstly isotonized and then ...
Dette, Holger, Birke, Melanie
core  

Piecewise linearisation of the first order loss function for families of arbitrarily distributed random variables [PDF]

, 2014
We discuss the problem of computing optimal linearisation parameters for the first order loss function of a family of arbitrarily distributed random variable.
Rossi, Roberto; id_orcid, Rossi, R., Hendrix, Eligius M.T., Hendrix, E.M.T.   +3 more
core  

Space-Efficient Dictionaries for Parameterized and Order-Preserving Pattern Matching [PDF]

, 2016
Let S and S' be two strings of the same length.We consider the following two variants of string matching. * Parameterized Matching: The characters of S and S' are partitioned into static characters and parameterized characters.
Hon, Wing-Kai, Shah, Rahul, Yang, Yilin, Thankachan, Sharma V., Sadakane, Kunihiko, Ganguly, Arnab, Hon, Wing Kai   +6 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Description of weakly additive order-preserving functionals on the plane

Владикавказский математический журнал, 2011
В работе получено описание пространства слабо аддитивных сохраняющих порядок функционалов на плоскости.
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Closure-preserving covers in function spaces [PDF]

, 2010
summary:It is shown that if $C_p(X)$ admits a closure-preserving cover by closed $\sigma$-compact sets then $X$ is finite. If $X$ is compact and $C_p(X)$ has a closure-preserving cover by separable subspaces then $X$ is metrizable. We also prove that if $
Sánchez, David Guerrero
core   +1 more source

Positivity-preserving discontinuous Galerkin scheme for linear hyperbolic equations with characteristics-informed augmentation

Results in Applied Mathematics
This paper presents a positivity-preserving discontinuous Galerkin (DG) scheme for the linear hyperbolic problem with variable coefficients on structured Cartesian domains.
Maurice S. Fabien
doaj   +1 more source