Results 111 to 120 of about 619,936 (293)

Sublinear and continuous order-preserving functions for noncomplete preorders

, 2002
We characterize the existence of a nonnegative, sublinear and continuous order-preserving function for a not necessarily complete preorder on a real convex cone in an arbitrary topological real vector space. As a corollary of the main result, we present necessary and sufficient conditions for the existence of such an order-preserving function for a ...
BOSI, GIANNI, ZUANON M.
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Coprime Factor Reduction of H-infinity Controllers [PDF]

, 2003
We consider the efficient solution of the coprime factorization based H infinity controller approximation problems by using frequency-weighted balancing related model reduction approaches.
Varga, Andras
core  

Learning Scoring Functions with Order-Preserving Losses and Standardized Supervision [PDF]

, 2011
We address the problem of designing surrogate losses for learning scoring functions in the context of label ranking. We extend to ranking problems a notion of order preserving losses previously introduced for multiclass classi?cation, and show that these losses lead to consistent formulations with respect to a family of ranking evaluation metrics.
Buffoni, David, Calauzènes, Clément, Gallinari, Patrick, Usunier, Nicolas   +3 more
openaire   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Characterizing minimal semantics-preserving slices of predicate-linear, free, liberal program schemas [PDF]

, 2011
This is a preprint version of the article - Copyright @ 2011 ElsevierA program schema defines a class of programs, all of which have identical statement structure, but whose functions and predicates may differ.
Laurence, MR, Michael R. Laurence, Robert M. Hierons, Laurence, Michael R., Sebastian Danicic, Hierons, Robert M., Hierons, RM, Danicic, S, Danicic, Sebastian, Laurence, Michael, Hierons, Robert   +10 more
core   +1 more source

Strongly order preserving semiflows generated by functional differential equations

Journal of Differential Equations, 1991
The authors' goal is to extend some of their previous results in the theory of monotone dynamical systems to certain systems of functional differential equations. The fundamental paper in this field was written by M. Hirsch and appeared in 1988; Hirsch established that most orbits of a strongly monotone semiflow on a strongly ordered space tend to a ...
Smith, Hal L, Thieme, Horst R
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source