Results 181 to 190 of about 12,783 (215)

Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cord

Neuroscience Letters, 2000
Orexin-A and orexin-B (also known as hypocretin-1 and hypocretin-2) are hypothalamic peptides that regulate feeding behavior, energy metabolism, and sleep-wake cycle. We determined the distribution of orexin-A and -B in the rat spinal cord, using sensitive radioimmunoassays and an immunohistochemical technique with three antisera specific for these ...
Y, Date, M S, Mondal, S, Matsukura, M, Nakazato   +3 more
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Orexin pathway in Parkinson’s disease: a review

Molecular Biology Reports, 2023
Parkinson's disease (PD) is a progressive neurodegenerative disease (NDD) caused by dopaminergic neuron degeneration in the substantia nigra (SN). Orexin is a neuropeptide that plays a role in the pathogenesis of PD. Orexin has neuroprotective properties in dopaminergic neurons. In PD neuropathology, there is also degeneration of orexinergic neurons in
Mohammed Alrouji, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Dalia Zaafar, Gaber El-Saber Batiha   +4 more
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Orexin A in adolescents with anxiety disorders

International Journal of Psychiatry in Clinical Practice, 2020
Objectives: The relationships between orexins and stress-related conditions have been well documented in animal studies. However, human studies confirming this relationship are limited. The aim of this study was to investigate the association between orexin-A and anxiety disorders in adolescents.
Ömer Faruk Akça, Necati Uzun, İbrahim Kılınç   +2 more
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Orexin: a gatekeeper of addiction

Nature Medicine, 2006
The neurotransmitter orexin regulates motivated behaviors such as arousal and feeding—and is now implicated in behaviors associated with addiction in rats. The release of orexin onto dopamine cells enables cocaine to induce the neuronal changes that lead to addiction-like behavior.
David Carr, Peter W Kalivas
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Narcolepsy in a hypocretin/orexin‐deficient chihuahua

Veterinary Record, 2003
A two‐year‐old male chihuahua suffered attacks of muscle weakness and immobility, although it had no family history of paroxysmal attacks. No neurological or blood biochemical abnormalities were recorded when it was first examined. The attacks were typically elicited by stimulation, such as feeding, and a case of sporadic narcolepsy‐cataplexy was ...
M, Tonokura, K, Fujita, M, Morozumi, Y, Yoshida, T, Kanbayashi, S, Nishino   +5 more
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Effects of orexin-A on memory processing

Peptides, 2002
Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one
Laura B, Jaeger, Susan A, Farr, William A, Banks, John E, Morley   +3 more
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Orexin-A expression in human peripheral tissues

Molecular and Cellular Endocrinology, 2003
Orexin-A is a neuropeptide present in the brain and is known to regulate feeding and sleeping. In this study, we examined the systemic distribution of orexin-A in human tissues. Immunoreactivity for orexin-A was detected in ganglion cells of the thoracic sympathetic trunk, myenteric plexuses and endocrine cells of the gastrointestinal tract, islet ...
Masao, Nakabayashi, Takashi, Suzuki, Kazuhiro, Takahashi, Kazuhito, Totsune, Yasunari, Muramatsu, Chika, Kaneko, Fumiko, Date, Junji, Takeyama, Andrew D, Darnel, Takuya, Moriya, Hironobu, Sasano   +10 more
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A role for hypocretin/orexin in motivation

Behavioural Brain Research, 2011
Obesity and drug addiction, both a result of aberrant motivated behavior, are growing problems in western society. Increased dopamine neurotransmission occurs with both drug-seeking and ingestive behaviors and has been linked to effort related functions. Hypocretin/orexin (Hcrt/ox) neurons have long been known to mediate arousal and feeding.
Jennifer L, Thompson, Stephanie L, Borgland   +1 more
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Orexin supplementation in narcolepsy treatment: A review

Medicinal Research Reviews, 2018
AbstractNarcolepsy is a rare, chronic neurological disease characterized by excessive daytime sleepiness, cataplexy, vivid hallucinations, and sleep paralysis. Narcolepsy occurs in approximately 1 of 3000 people, affecting mainly adolescents aged 15 to 30 years. Recently, people with narcolepsy were shown to exhibit extensive orexin/hypocretin neuronal
Eugenie Nepovimova, Jana Janockova, Jan Misik, Stepan Kubik, Ales Stuchlik, Karel Vales, Jan Korabecny, Eva Mezeiova, Rafael Dolezal, Ondrej Soukup, Tereza Kobrlova, Ngoc Lam Pham, Thuy Duong Nguyen, Jan Konecny, Kamil Kuca   +14 more
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Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors

Journal of Neuroscience Research, 2016
Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral hypothalamus. Much evidence has indicated that central orexinergic systems play numerous functions including energy metabolism, feeding behavior, sleep/wakefulness, and neuroendocrine and sympathetic activation.
Xin-Yi, Chen, Lei, Chen, Yi-Feng, Du
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