Results 201 to 210 of about 359,848 (279)

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Genetic background shapes the transcriptional activity and phenotypic contribution of a horizontally acquired region in yeast. [PDF]

Mol Biol Evol
Romero A, Bastías C, De Chiara M, Saayman X, Cherkaoui H, Barré B, Cubillos FA, Martínez C, Kessi-Pérez EI, Liti G, Salinas F.   +10 more
europepmc   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

Sequence heterogeneity in pneumonia virus of mice reveals G gene-dependent modulation of virulence. [PDF]

J Virol
Adenugba AR, Bohn P, Yu J, Fehrholz M, Bergmann AK, Smyth RP, Krempl CD.   +6 more
europepmc   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Dynamic evolution of retroviral envelope-derived sequences in primates. [PDF]

Virus Evol
Kitao K, Kryukov K, Jin L, Shintaku Y, Hayakawa T, Nakagawa S.   +5 more
europepmc   +1 more source

Monitoring wildlife health for diseases with visible signs by integrating camera traps with marked individuals

Conservation Biology, EarlyView.
Abstract Monitoring wildlife health is essential for conservation and management, wildlife and livestock welfare, and public health in a One Health framework. Yet, wildlife health monitoring often requires long‐term fieldwork and intensive sampling, which can be costly or logistically challenging, especially for remote, rare, or elusive populations. To
Jonathan Tichon, Roi Lapid, Roni King, Elyasaf Freiman, Orr Spiegel, Erez Baruchi, Aviam Atar, Shirli Bar‐David, David Saltz   +8 more
wiley   +1 more source

Correction: Polysaccharide-stabilized biogenic CuO/SeO₂ nanocomposites: green synthesis, physicochemical characterization, and enhanced antioxidant, antimicrobial, and selective anticancer activities. [PDF]

RSC Adv
Elattar KM, Elsayed A, Elmetwalli A, El-Hersh MS, El-Khateeb A, Zaher AA, Bayoumy NM, Salam MA, Ghoneem KM, Al-Askar AA.   +9 more
europepmc   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Attenuation without protective immunogenicity: effects of codon-pair deoptimization on foot-and-mouth disease virus serotype O in swine. [PDF]

Sci Rep
Lorenz C, Wisnewski K, Weber S, Deutschmann P, Beer M, Eschbaumer M.   +5 more
europepmc   +1 more source