Results 181 to 190 of about 7,628 (191)

SARS-CoV-2 ORF3a Interacts and Stabilizes HMOX1 Expression and Function

2023
This thesis describes the interaction between SARS-CoV-2 Open Reading Frame 3a (ORF3a) and the Heme Oxygenase 1 (HMOX1). SARS-CoV-2 is a novel coronavirus and the causative agent of COVID-19, the highly contagious infection behind the 2019 COVID-19 pandemic.
openaire   +1 more source

Insights into Ion Conduction Mechanisms Through the ORF3a Channel by Computational Modelling

Investigating the selectivity and mechanism of the SARSCoV-2 ORF3a protein channel remains a significant challenge within the scientific community. Speculation surrounds its potential calcium ion selectivity, implicating a significant role in the pathology of COVID-19 by influencing viral replication and the cellular virus response.
Nuria Anguita-Ortiz, Andrea Lombardi, Noelia Faginas-Lago, Juan J. Nogueira   +3 more
openaire   +2 more sources

SARS-CoV-2 protein ORF3a induces Atg8ylation of lysosomal membranes

AbstractAutophagy Conjugation machinery forms a center piece of autophagy and is essential for sequestration of a broad range of cargo destined for degradation. Apart from its role in canonical autophagy, recent evidence suggests an unconventional role of conjugation machinery.
Deepa Ajnar, Ananya Sarkar, Seema Riyaz, Poornima Menon, Dipranil Dutta, Pulkit Asati, Priyanka Sharma, Sai P. Pydi, Suresh Kumar   +8 more
openaire   +1 more source

Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition

Biochimie
Inhibition of autophagy is one of the hallmarks of the SARS-CoV-2 infection. Recently it was reported that SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes via interaction with VPS39 thus preventing binding of homotypic fusion and protein sorting (HOPS) complex to RAB7 GTPase.
George A, Saratov, Alexey A, Belogurov, Anna A, Kudriaeva   +2 more
openaire   +2 more sources

ASC Dynamics Associated with ORF3a Protein Expression in Microvascular Lung Endothelial Cells

Proceedings of the Bulgarian Academy of Sciences
The NLRP3 inflammasome is a key sensor of cellular stress and pathogen-associated signals in the innate immune system. Using confocal fluorescence microscopy in microvascular lung endothelial cells, we examined ASC speck formation following expression of the SARS-CoV-2 ORF3a protein.
Yuliia Mariienko, Diana Pendicheva, Soren Hayrabedyan, Krassimira Todorova   +3 more
openaire   +1 more source

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

Developmental Cell, 2021
Mingming Ji, Yi Shi, Yu-Hai Bi
exaly  

SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection

Autophagy, 2022
Ziwei Yang, Ting Pan, Xubing Long
exaly  

SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation

Molecular Therapy, 2023
Thomas Kehrer, Lisa Miorin, Weibin Zhou
exaly  

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2

Virus Research, 2021
Sk Sarif Hassan, Pabitra Pal Choudhury, Bidyut Roy   +2 more
exaly  

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC

FASEB Journal, 2019
Kam-Leung Siu, Kit-San Yuen, Zi-Wei Ye
exaly