Results 1 to 10 of about 572,658 (301)

Salivary Glands and Viral Pathogenesis. [PDF]

J Dent Res
The oral cavity is an epidemiologically relevant route of viral transmission due to the shedding of viruses in saliva. With advancements in salivary diagnostics, an increasing number of viruses have been detected. However, the anatomic source of virus in saliva is still largely unknown.
Atyeo N, Maldonado JO, Warner BM, Chiorini JA.   +3 more
europepmc   +3 more sources

Editorial overview: Viral pathogenesis. [PDF]

Curr Opin Virol, 2022
Bertoletti A, Iannacone M.
europepmc   +4 more sources

High Heritability Is Compatible with the Broad Distribution of Set Point Viral Load in HIV Carriers. [PDF]

, 2015
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Bonhoeffer, S, Fraser, C, Leventhal, GE
core   +11 more sources

Revealing the molecular signatures of host-pathogen interactions. [PDF]

, 2011
Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co ...
C Herdtweck, C Loscos, C Sik-Lányi, F Yan, G Xing, GJ Ward, H Kolivand, H Kolivand, Hoshang Kolivand, J Blinn, J Hensley, K Jacobs, K Kaneda, K Kilteni, K Tadamura, KL Wilson, Kolivand, L Hosek, M Aittala, M Haller, M Kanbara, M Knecht, M Slater, M Sunar, Mohd Shahrizal Sunar, MS Sunar, MZ Shao, N Greene, P Debevec, R Azuma, R Ji, R Ji, R Kittler, R Kittler, R Kittler, R Klassen, R Perez, RC Yeoh, Rongrong Ji, S Gibson, S Lee, T Annen, T Guan, T Naemura, T Nishita, W Donnelly, W Hartmann, W Reeves, Y Dobashi, Y Dobashi, Y Feng, Y Liu, Y Liu, Z Noh   +53 more
core   +25 more sources

Targeting Pim kinases in hematological cancers: molecular and clinical review

Molecular Cancer, 2023
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular ...
Marcia Bellon, Christophe Nicot
doaj   +1 more source

Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection

Viruses, 2020
Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus–host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an ...
Veronika Bernhauerová, Veronica V. Rezelj, Marco Vignuzzi   +2 more
doaj   +1 more source

Zika virus spreads through infection of lymph node-resident macrophages

Cell Reports, 2023
Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells.
Glennys V. Reynoso, David N. Gordon, Anurag Kalia, Cynthia C. Aguilar, Courtney S. Malo, Maya Aleshnick, Kimberly A. Dowd, Christian R. Cherry, John P. Shannon, Sophia M. Vrba, Autumn C. Holmes, Yael Alippe, Sonia Maciejewski, Kenichi Asano, Michael S. Diamond, Theodore C. Pierson, Heather D. Hickman   +16 more
doaj   +1 more source

Impacts of Humanized Mouse Models on the Investigation of HIV-1 Infection: Illuminating the Roles of Viral Accessory Proteins in Vivo

Viruses, 2015
Human immunodeficiency virus type 1 (HIV-1) encodes four accessory genes: vif, vpu, vpr, and nef. Recent investigations using in vitro cell culture systems have shed light on the roles of these HIV-1 accessory proteins, Vif, Vpr, Vpu, and Nef, in ...
Eri Yamada, Rokusuke Yoshikawa, Yusuke Nakano, Naoko Misawa, Yoshio Koyanagi, Kei Sato   +5 more
doaj   +1 more source

Where do we Stand after Decades of Studying Human Cytomegalovirus?

Microorganisms, 2020
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging between 56% and 94%, strictly dependent on the socioeconomic background of the ...
Francesca Gugliesi, Alessandra Coscia, Gloria Griffante, Ganna Galitska, Selina Pasquero, Camilla Albano, Matteo Biolatti   +6 more
doaj   +1 more source

TRIM22. A Multitasking Antiviral Factor

Cells, 2021
Viral invasion of target cells triggers an immediate intracellular host defense system aimed at preventing further propagation of the virus. Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors ...
Isabel Pagani, Guido Poli, Elisa Vicenzi
doaj   +1 more source