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The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis
Microorganisms, 2023 The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance in microbiome composition, can have profound effects on various aspects of human health, including susceptibility to viral ...
Jay Rappaport +2 more
exaly +2 more sources
Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis
Viruses, 2023 Ferroptosis is a novelty form of regulated cell death, and it is mainly characterized by iron accumulation and lipid peroxidation in the cells. Its underlying mechanism is related to the amino acid, iron, and lipid metabolisms.
Riwei Huang +3 more
semanticscholar +2 more sources
Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19
Frontiers in Microbiology, 2022 The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-19-related morbidity and mortality, and the high mutability of the virus.
Jian-Tao Zhang +6 more
semanticscholar +1 more source
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
bioRxiv, 2022 We and others have previously shown that the SARS-CoV-2 accessory protein ORF6 is a powerful antagonist of the interferon (IFN) signaling pathway by directly interacting with Nup98-Rae1 at the nuclear pore complex (NPC) and disrupting bidirectional ...
Thomas Kehrer +39 more
semanticscholar +1 more source
Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
Viruses, 2022 Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for large-scale biosynthesis. Based on studies of the cellular changes that contribute to
Charles N. S. Allen +3 more
semanticscholar +1 more source
SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns
Frontiers in Immunology, 2021 There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles during infection are still not completely understood.
Natalia Redondo +3 more
semanticscholar +1 more source
Sex Differences in Respiratory Viral Pathogenesis and Treatments.
Annual Review of Virology, 2021 Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 ...
R. Ursin, S. Klein
semanticscholar +1 more source
new microbes and new infections, 2021 Defined as helpful live bacteria that can provide medical advantages to the host when administered in tolerable amounts, oral probiotics might be worth considering as a possible preventive or therapeutic modality to mitigate coronavirus disease 2019 ...
P. Baindara +4 more
semanticscholar +1 more source
The emerging role of perivascular cells (pericytes) in viral pathogenesis
Journal of General Virology, 2021 Viruses may exploit the cardiovascular system to facilitate transmission or within-host dissemination, and the symptoms of many viral diseases stem at least in part from a loss of vascular integrity.
Teemapron Butsabong +3 more
semanticscholar +1 more source
Drugs of Abuse and Their Impact on Viral Pathogenesis
Viruses, 2021 Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the
J. Blackard, K. Sherman
semanticscholar +1 more source