Results 11 to 20 of about 2,694,187 (254)
PathogensCytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals.
C. Venturini, J. Breuer
semanticscholar +2 more sources
Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS
Pathogens, 2021 (1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae.
Hannah K. Hopkins +2 more
semanticscholar +1 more source
Critical Involvement of TFIIB in Viral Pathogenesis
Frontiers in Molecular Biosciences, 2021 Viral infections and the harm they cause to their host are a perpetual threat to living organisms. Pathogenesis and subsequent spread of infection requires replication of the viral genome and expression of structural and non-structural proteins of the ...
Michael J. O’Brien, A. Ansari
semanticscholar +1 more source
Pellino Proteins in Viral Immunity and Pathogenesis
, 2023 Pellino proteins are a family of evolutionarily conserved ubiquitin ligases involved in intracellular signaling in a wide range of cell types. They are essential for microbe detection and the initiation of innate and adaptive immune responses.
Liselotte E. Jensen
core +1 more source
Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2021 Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie, Jianxiong Zeng
semanticscholar +1 more source
Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection
Viruses, 2020 Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus–host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an ...
Veronika Bernhauerová +2 more
doaj +1 more source
Targeting Pim kinases in hematological cancers: molecular and clinical review
Molecular Cancer, 2023 Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling, Pim kinases regulate cell proliferation, survival, metabolism, cellular ...
Marcia Bellon, Christophe Nicot
doaj +1 more source
Zika virus spreads through infection of lymph node-resident macrophages
Cell Reports, 2023 Summary: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells.
Glennys V. Reynoso +16 more
doaj +1 more source
Viruses, 2015 Human immunodeficiency virus type 1 (HIV-1) encodes four accessory genes: vif, vpu, vpr, and nef. Recent investigations using in vitro cell culture systems have shed light on the roles of these HIV-1 accessory proteins, Vif, Vpr, Vpu, and Nef, in ...
Eri Yamada +5 more
doaj +1 more source
MHC Class II Tetramer Labeling of Human Primary CD4+ T Cells from HIV Infected Patients
Bio-Protocol, 2017 Major Histocompatibility Complex (MHC) tetramers have been used for two decades to detect, isolate and characterize T cells specific for various pathogens and tumor antigens.
Moran Galperin +4 more
doaj +1 more source