Results 11 to 20 of about 370,057 (263)

TRIM22. A Multitasking Antiviral Factor

Cells, 2021
Viral invasion of target cells triggers an immediate intracellular host defense system aimed at preventing further propagation of the virus. Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors ...
Isabel Pagani, Guido Poli, Elisa Vicenzi
doaj   +1 more source

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

mBio, 2019
Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus ...
Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley   +13 more
doaj   +1 more source

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

Journal of Hematology & Oncology, 2018
Background HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells.
Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz, Christophe Nicot   +4 more
doaj   +1 more source

Tuning the Orchestra: HCMV vs. Innate Immunity

Frontiers in Microbiology, 2020
Understanding how the innate immune system keeps human cytomegalovirus (HCMV) in check has recently become a critical issue in light of the global clinical burden of HCMV infection in newborns and immunodeficient patients. Innate immunity constitutes the
Valentina Dell’Oste, Matteo Biolatti, Ganna Galitska, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Alessandra Zingoni, Cristina Cerboni, Marco De Andrea, Marco De Andrea   +9 more
doaj   +1 more source

Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses

mBio, 2016
Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat due in part to its association with congenital abnormalities. Other globally relevant flaviviruses include dengue virus (DENV) and West Nile virus (WNV).
Leslie Goo, Kimberly A. Dowd, Alexander R. Y. Smith, Rebecca S. Pelc, Christina R. DeMaso, Theodore C. Pierson   +5 more
doaj   +1 more source

Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing

mBio, 2015
Flaviviruses sample an ensemble of virion conformations resulting from the conformational flexibility of their structural proteins. To investigate how sequence variation among strains impacts virus breathing, we performed studies with the monoclonal ...
Kimberly A. Dowd, Christina R. DeMaso, Theodore C. Pierson   +2 more
doaj   +1 more source

The Fatty Acid Lipid Metabolism Nexus in COVID-19

Viruses, 2021
Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects
Jerome E. Tanner, Caroline Alfieri
doaj   +1 more source

FBXW7: a critical tumor suppressor of human cancers

Molecular Cancer, 2018
The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes, such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer Cell 26:455-64, 2014; Skaar JR et al., Nat Rev Drug Discov 13:889-
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot   +2 more
doaj   +1 more source

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

npj Vaccines, 2023
Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of congenital disease during a major outbreak in the Americas in 2016.
Brooke Bollman, Naveen Nunna, Kapil Bahl, Chiaowen Joyce Hsiao, Hamilton Bennett, Scott Butler, Bryant Foreman, Katherine E. Burgomaster, Maya Aleshnick, Wing-Pui Kong, Brian E. Fisher, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Barney S. Graham, Kimberly A. Dowd, Theodore C. Pierson, Andrea Carfi   +16 more
doaj   +1 more source

Complement and viral pathogenesis

Virology, 2011
The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses.
Stoermer, Kristina A., Morrison, Thomas E.   +1 more
openaire   +2 more sources