Results 41 to 50 of about 2,694,187 (254)

TRIM Proteins in Host Defense and Viral Pathogenesis

Current Clinical Microbiology Reports, 2020
Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin ligases involved in different cellular functions. Of special interest are their roles in innate immunity, inflammation, and virus replication.
M. Giraldo, Adam Hage, S. van Tol, Ricardo Rajsbaum   +3 more
semanticscholar   +1 more source

Studies on the Morphogenesis of Murine Cytomegalovirus [PDF]

, 1986
Two modes of assembly of murine cytomegalovirus (MCMV) were observed in cultured mouse embryo fïbroblasts, generating two morphologically different types of viral particles: monocapsid virions and multicapsid virions.
Reddehase, M. J., Reddehase, Matthias J., U.H. Koszinowski, G.M. Keil, M.J. Reddehase, Koszinowski, Ulrich H., Koszinowski, U. H., Keil, Günther M., F. Weiland, Weiland, Frank   +9 more
core   +1 more source

Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses

Journal of Virology, 2020
Metabolic syndrome increases the risk of severe disease due to viral infection. Yet few studies have assessed the pathogenesis of respiratory viruses in high-risk populations.
Maria Smith, Rebekah Honce, S. Schultz-Cherry   +2 more
semanticscholar   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
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Towards understanding of the replication and pathogenesis of dengue infection [PDF]

, 2007
Dengue is the most important human viral disease transmitted by arthropod vectors and over half of the world's population live in areas at risk of infection. Currently there is neither specific treatment nor vaccine to tackle this emerging disease. The
Umareddy, Indira
core   +1 more source

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase

mBio, 2010
The swine-origin H1N1 influenza A virus emerged in early 2009 and caused the first influenza pandemic in 41 years. The virus has spread efficiently to both the Northern and the Southern Hemispheres and has been associated with over 16,000 deaths.
Brett W. Jagger, Matthew J. Memoli, Zong-Mei Sheng, Li Qi, Rachel J. Hrabal, Genevieve L. Allen, Vivien G. Dugan, Ruixue Wang, Paul Digard, John C. Kash, Jeffery K. Taubenberger   +10 more
doaj   +1 more source

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]

, 2010
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H., G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +7 more
core   +1 more source

Protocol for analyzing and visualizing antiviral immune responses after acute infection of the murine oral mucosa

STAR Protocols, 2021
Summary: The oral mucosa is an important site for virus infection and transmission, yet few animal models exist to examine the virology, pathology, and immunology of acute oral mucosal viral infection.
John P. Shannon, Christian R. Cherry, Sophia M. Vrba, Heather D. Hickman   +3 more
doaj   +1 more source

Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis

Oxidative Medicine and Cellular Longevity, 2019
Oxidative stress is induced once the balance of generation and neutralization of reactive oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural and diseased processes.
Zhenzhen Zhang, Liang Rong, Yi-Ping Li
semanticscholar   +1 more source

Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice [PDF]

, 2010
Dengue virus (DENV), a mosquito-borne flavivirus, is a public health problem in many tropical countries. Recent clinical data have shown an association between levels of different chemokines in plasma and severity of dengue.
Mauro M Teixeira, Besnard, Anne-Gaëlle, Danielle G Souza, Fagundes, C.T., Teixeira, Mauro M, Guabiraba Rodrigo, Fagundes Caio T., Teixeira Mauro M., Anne-Gaëlle Besnard, Souza, Danielle G., Souza Danielle G., Danielle G. Souza, Mauro M. Teixeira, Teixeira, M.M., Caio T Fagundes, Ryffel Bernhard, Bernhard Ryffel, Souza, Danielle G, Besnard, A., Marques, Rafael Elias, Fagundes, Caio T., Ryffel, Bernhard, Rodrigo Guabiraba, Fagundes, Caio T, Marques Rafael Elias, Marques, R.E., Guabiraba, Rodrigo, Guabiraba Brito, R., Besnard Anne-Gaëlle, Rafael Elias Marques, Caio T. Fagundes   +30 more
core   +2 more sources