Results 21 to 30 of about 2,694,187 (254)

Where do we Stand after Decades of Studying Human Cytomegalovirus?

Microorganisms, 2020
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging between 56% and 94%, strictly dependent on the socioeconomic background of the ...
Francesca Gugliesi, Alessandra Coscia, Gloria Griffante, Ganna Galitska, Selina Pasquero, Camilla Albano, Matteo Biolatti   +6 more
doaj   +1 more source

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

mBio, 2019
Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus ...
Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley   +13 more
doaj   +1 more source

Tuning the Orchestra: HCMV vs. Innate Immunity

Frontiers in Microbiology, 2020
Understanding how the innate immune system keeps human cytomegalovirus (HCMV) in check has recently become a critical issue in light of the global clinical burden of HCMV infection in newborns and immunodeficient patients. Innate immunity constitutes the
Valentina Dell’Oste, Matteo Biolatti, Ganna Galitska, Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Alessandra Zingoni, Cristina Cerboni, Marco De Andrea, Marco De Andrea   +9 more
doaj   +1 more source

TRIM22. A Multitasking Antiviral Factor

Cells, 2021
Viral invasion of target cells triggers an immediate intracellular host defense system aimed at preventing further propagation of the virus. Viral genomes or early products of viral replication are sensed by a number of pattern recognition receptors ...
Isabel Pagani, Guido Poli, Elisa Vicenzi
doaj   +1 more source

JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

Journal of Hematology & Oncology, 2018
Background HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells.
Marcia Bellon, Ramona Moles, Hassiba Chaib-Mezrag, Joanna Pancewicz, Christophe Nicot   +4 more
doaj   +1 more source

The pathogenesis of dengue. [PDF]

, 2011
Dengue is an important cause of childhood and adult morbidity in Asian and Latin American countries and its geographic footprint is growing. The clinical manifestations of dengue are the expression of a constellation of host and viral factors, some ...
Whitehorn, J, Cameron P. Simmons, Simmons, Cameron, Simmons, CP, Whitehorn, Jamie, Jamie Whitehorn, Simmons, Cameron P   +6 more
core   +1 more source

De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis

, 2021
Alphaviruses are positive-sense RNA arboviruses that are capable of causing severe disease in otherwise healthy individuals. There are many aspects of viral infection that determine pathogenesis and major efforts regarding the identification and ...
Kevin J. Sokoloski, Autumn T. LaPointe
core   +1 more source

Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses

mBio, 2016
Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat due in part to its association with congenital abnormalities. Other globally relevant flaviviruses include dengue virus (DENV) and West Nile virus (WNV).
Leslie Goo, Kimberly A. Dowd, Alexander R. Y. Smith, Rebecca S. Pelc, Christina R. DeMaso, Theodore C. Pierson   +5 more
doaj   +1 more source

Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]

, 2012
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
Ebermann, L., Čičin-Šain, Luka, Luka Čičin-Šain, Rosaely Casalegno-Garduño (111456), Carlos A Guzmán, Ruzsics, Zsolt, van Rooijen, Nico, Koszinowski, U., van Rooijen, N., Ulrich Koszinowski, Linda Ebermann (111451), Zsolt Ruzsics (75383), Ruzsics, Z., Nico van Rooijen, Guzman, C.A., Casalegno-Garduno, R., Ulrich Koszinowski (111457), Ruzsics Zsolt, Casalegno-Garduño, Rosaely, Nico van Rooijen (4110211), Koszinowski, Ulrich H., Zsolt Ruzsics, Carlos A. Guzmán (111454), Luka Čičin-Šain (111459), Guzmán, Carlos A., Rooijen, N. van, Guzmán Carlos A., Ebermann Linda, Linda Ebermann, Cicin-Sain, L., Čičin-Šain Luka, Guzmán, Carlos A, Casalegno-Garduño Rosaely, Koszinowski, Ulrich, Rosaely Casalegno-Garduño, Ebermann, Linda, van Rooijen Nico, Koszinowski Ulrich   +37 more
core   +2 more sources

Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing

mBio, 2015
Flaviviruses sample an ensemble of virion conformations resulting from the conformational flexibility of their structural proteins. To investigate how sequence variation among strains impacts virus breathing, we performed studies with the monoclonal ...
Kimberly A. Dowd, Christina R. DeMaso, Theodore C. Pierson   +2 more
doaj   +1 more source