Results 31 to 40 of about 370,057 (263)

Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo

Pathogens and Immunity, 2020
Background: Microbial translocation occurs after damage to the structural and/or immunological barrier of the gastrointestinal (GI) tract into circulation.
Carol L. Vinton, Carly E. Starke, Alexandra M. Ortiz, Stephen H. Lai, Jacob K. Flynn, Ornella Sortino, Kenneth Knox, Irini Sereti, Jason Brenchley   +8 more
doaj   +1 more source

Widespread and dynamic expression of granzyme C by skin-resident antiviral T cells

Frontiers in Immunology, 2023
After recognition of cognate antigen (Ag), effector CD8+ T cells secrete serine proteases called granzymes in conjunction with perforin, allowing granzymes to enter and kill target cells.
Ramon A. Lujan, Ramon A. Lujan, Luxin Pei, John P. Shannon, Nathânia Dábilla, Patrick T. Dolan, Heather D. Hickman   +6 more
doaj   +1 more source

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection

Viruses, 2017
The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection.
Marcia Bellon, Christophe Nicot
doaj   +1 more source

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

Molecules, 2023
The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers.
Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin   +13 more
doaj   +1 more source

Pathogenesis of Viral Infections

Veterinary Clinics of North America: Small Animal Practice, 1986
The article considers factors that influence pathogenesis, initiation of infection, dissemination of virus within a host, lytic viral infections, viral immunosuppression, viral immunopathology, and viral oncogenesis.
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Viral pathogenesis and immune control [PDF]

Journal of Neurovirology, 2002
Understanding viral structure-function relationships, interactions with host cells or the host’s immune system are crucial for understanding the pathomechanisms of viral infections, modulation of immune responses, and the development of effective and preventative and therapeutic measures.
Schneider-Schaulies, Sibylle, Rima, Bertus K., Hünig, Thomas   +2 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

mBio, 2011
Secondary bacterial infections increase disease severity of influenza virus infections and contribute greatly to increased morbidity and mortality during pandemics.
John C. Kash, Kathie-Anne Walters, A. Sally Davis, Aline Sandouk, Louis M. Schwartzman, Brett W. Jagger, Daniel S. Chertow, Li Qi, Rolf E. Kuestner, Adrian Ozinsky, Jeffery K. Taubenberger   +10 more
doaj   +1 more source