Results 31 to 40 of about 2,694,187 (254)

Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis

Journal of Medical Virology, 2020
We have applied mathematical modeling to investigate the infections of the ongoing coronavirus disease‐2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 virus.
Sean Quan Du, Weiming Yuan
semanticscholar   +1 more source

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

npj Vaccines, 2023
Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of congenital disease during a major outbreak in the Americas in 2016.
Brooke Bollman, Naveen Nunna, Kapil Bahl, Chiaowen Joyce Hsiao, Hamilton Bennett, Scott Butler, Bryant Foreman, Katherine E. Burgomaster, Maya Aleshnick, Wing-Pui Kong, Brian E. Fisher, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Barney S. Graham, Kimberly A. Dowd, Theodore C. Pierson, Andrea Carfi   +16 more
doaj   +1 more source

The Fatty Acid Lipid Metabolism Nexus in COVID-19

Viruses, 2021
Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects
Jerome E. Tanner, Caroline Alfieri
doaj   +1 more source

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

mSystems, 2020
At the surge of the coronavirus disease 2019 (COVID-19) pandemic, we detected and identified six functional domains (I to VI) in the SARS-CoV-2 3a protein. Our analysis showed that the functional domains were linked to virulence, infectivity, ion channel
E. Issa, Georgi Merhi, Balig Panossian, Tamara Salloum, S. Tokajian   +4 more
semanticscholar   +1 more source

Human Metapneumovirus Induces Mucin 19 Which Contributes to Viral Pathogenesis

, 2020
Human Metapneumovirus (HMPV) remains one of the most common viral infections causing acute respiratory tract infections, especially in young children, elderly, and immunocompromised populations.
Banos-Lara, Ma Del, Nagarjuna R. Cheemarla, Cheemarla, Nagarjuna R, McBride, Kaitlin, Ma. del Rocio Banos-Lara, Kaitlin McBride, Antonieta Guerrero-Plata, Guerrero-Plata, Antonieta   +7 more
core   +1 more source

Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs [PDF]

, 2009
This paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do
Nicholas J. Savill, Alexandersen, Soren, Quan, Melvyn, Quan, M., Melvyn Quan, Louise Matthews, Howey, R., Matthews, L., Savill, Nicholas J., Matthews, Louise, Savill, N.J., Howey, Richard, Mark Woolhouse, Woolhouse, Mark; id_orcid, Søren Alexandersen, Woolhouse, M., Alexandersen, S., Richard Howey   +17 more
core   +1 more source

FBXW7: a critical tumor suppressor of human cancers

Molecular Cancer, 2018
The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes, such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer Cell 26:455-64, 2014; Skaar JR et al., Nat Rev Drug Discov 13:889-
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot   +2 more
doaj   +1 more source

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E, Woodward, Martin J, Rooks, David, Rooks, D. J., Smith, Darren L, McCarthy, Alan J, McDonald, James E; id_orcid, Woodward, Martin J., Darren L. Smith, Smith, Darren, Rooks, David J, David J. Rooks, Martin J. Woodward, McCarthy, Alan, McCarthy, A. J., Smith, D. L., Heather E. Allison, McDonald, James, Allison, Heather, James E. McDonald, Woodward, Martin, Alan J. McCarthy, McDonald, J. E., Allison, H. E.   +23 more
core   +1 more source

The role of goblet cells in viral pathogenesis

The FEBS Journal, 2020
Goblet cells are specialized epithelial cells that are essential to the formation of the mucus barriers in the airways and intestines. Armed with an arsenal of defenses, goblet cells can rapidly respond to infection but must balance this response with ...
V. Cortez, S. Schultz-Cherry
semanticscholar   +1 more source

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +7 more sources