Results 61 to 70 of about 2,694,187 (254)
Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
Viruses, 2017 The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection.
Marcia Bellon, Christophe Nicot
doaj +1 more source
Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands
Molecules, 2023 The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers.
Zhicheng Zhou +13 more
doaj +1 more source
Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis
bioRxiv, 2021 A significant fraction of sudden death in children and young adults is due to myocarditis, an inflammatory disease of the heart, most often caused by viral infection.
Madhav Mantri +6 more
semanticscholar +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation
Cell, 2017 Summary Receptor-interacting kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
B. Daniels +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression [PDF]
, 2010 Background: Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by
Scheuring Urban J +17 more
core +1 more source
Viral fitness: history and relevance for viral pathogenesis and antiviral interventions.
Pathogens and Disease, 2019 The quasispecies dynamics of viral populations (continuous generation of variant genomes and competition among them) has as one of its frequent consequences variations in overall multiplication capacity, a major component of viral fitness. This parameter
E. Domingo +4 more
semanticscholar +1 more source
Emerging Microbes and Infections, 2020 Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission.
Ling Lin +3 more
semanticscholar +1 more source
Autophagy in Viral Infection and Pathogenesis
Frontiers in Cell and Developmental Biology, 2021 As an evolutionarily conserved cellular process, autophagy plays an essential role in the cellular metabolism of eukaryotes as well as in viral infection and pathogenesis.
Shan Liang +4 more
semanticscholar +1 more source