Results 61 to 70 of about 572,658 (301)

Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells

Molecular Cancer
Background Dysregulation of immune surveillance is tightly linked to the development of metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC); however, its underlying mechanisms remain unclear.
Ying Xie, Yu Huang, Zhi-Yong Li, Weihua Jiang, Nan-Xi Shi, Yuanzhi Lu, Guangchao Cao, Zhinan Yin, Xue-Jia Lin   +8 more
doaj   +1 more source

Viral Pathogenesis

, 2014
Viral pathogenesis describes the processes by which viral infections cause diseases and involves virus–host interactions at the cellular and systemic level that determine whether a virus will cause a disease, what form that disease takes, and how severe the disease will be.
openaire   +1 more source

Autoimmune neurological conditions associated with Zika virus infection [PDF]

, 2018
Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids.
Acosta-Ampudia, Yeny, Anaya, Juan-Manuel, Castillo-Medina, Luis F, Halstead, Susan, Monsalve, Diana M, Pacheco, Yovana, Ramírez-Santana, Carolina, Rodríguez, Yhojan, Willison, Hugh J.   +8 more
core   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Chimeric Fusion (F) and Attachment (G) Glycoprotein Antigen Delivery by mRNA as a Candidate Nipah Vaccine

Frontiers in Immunology, 2021
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from bats-to-humans with almost annual regional outbreaks characterized by documented human-to-human transmission and high fatality rates. Currently, no vaccine against
Rebecca J. Loomis, Anthony T. DiPiazza, Samantha Falcone, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Olubukola M. Abiona, Lauren A. Chang, Ria T. Caringal, Vladimir Presnyak, Elisabeth Narayanan, Yaroslav Tsybovsky, Deepika Nair, Geoffrey B. Hutchinson, Guillaume B. E. Stewart-Jones, Lisa A. Kueltzo, Sunny Himansu, John R. Mascola, Andrea Carfi, Barney S. Graham   +18 more
doaj   +1 more source

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis [PDF]

Trends in Microbiology, 2018
Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families ​all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remove ADP-ribose, a common post-translation modification,
Fehr, A, Jankevicius, G, Ahel, I, Perlman, S   +3 more
openaire   +2 more sources

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration

Skeletal Muscle, 2019
Background During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical.
David Hardy, Mylène Fefeu, Aurore Besnard, David Briand, Paméla Gasse, Fernando Arenzana-Seisdedos, Pierre Rocheteau, Fabrice Chrétien   +7 more
doaj   +1 more source

Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil [PDF]

, 2016
Background: The outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern.
Biek, Roman, Brennan, Benjamin, Clark, Jordan J., Cordeiro, Marli T., Cumberworth, Stephanie L., Da Silva Filipe, Ana, Davis, Christopher, Donald, Claire L., Fall, Gamou, Freitas de Oliveira França, Rafael, Hughes, Joseph, Kohl, Alain, Lindenbach, Brett D., McLauchlan, John, Owsianka, Anna M., Patel, Arvind H., Pena, Lindomar J., Rehwinkel, Jan, Rezelj, Veronica V., Sall, Amadou A., Schnettler, Esther, Selinger, Martin, Varjak, Margus, Wilkie, Gavin S., Zuvanov, Luíza   +24 more
core   +3 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source