Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies [PDF]
Microbial PhysiologyIntroduction: Viroporins are small multifunctional proteins that modify cellular membranes facilitating processes such as viral nucleic acid entry and the release of virions from infected cells.
Jianing Wang +6 more
doaj +4 more sources
The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogensViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus.
Vicken Aknadibossian +5 more
doaj +6 more sources
Membrane Activity and Viroporin Assembly for the SARS-CoV-2 E Protein Are Regulated by Cholesterol [PDF]
BiomoleculesThe SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to deform cell membranes for viral budding.
Zaret Denieva +2 more
exaly +5 more sources
Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV) [PDF]
Virus ResearchCoronaviruses (CoVs) are significant animal and human pathogens, characterized by being enveloped RNA viruses with positive-sense single-stranded RNA. The Coronaviridae family encompasses four genera, among which gammacoronaviruses pose a major threat to
Chi-Young Wang, Hung-Jen Liu
exaly +5 more sources
The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholPotato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
europepmc +3 more sources
Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins. [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins.
Negi V, Miller AS, Kuhn RJ.
europepmc +5 more sources
Virology Journal, 2023 Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–
Ulrike Breitinger +3 more
doaj +3 more sources
Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Frontiers in Microbiology, 2019 Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate
Ming-Fu Chang +2 more
exaly +4 more sources
The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Viroporins have been exclusively found in enveloped clinically important animal viruses. Here, we report that the highly conserved 6K1 and its homologous 7K in viruses of the family Potyviridae (potyvirids) are functional viroporins.
Fangfang Li +2 more
exaly +3 more sources
The B169L protein of African swine fever virus functions as a viroporin that activates the calcium-mediated inflammasome. [PDF]
PLoS PathogAfrican swine fever (ASF) is a highly contagious and often fatal viral disease caused by African swine fever virus (ASFV), which poses a significant economic burden on the global pig industry.
Li J +14 more
europepmc +2 more sources