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Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
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Viruses, 2022 The leader of the capsid (LC) protein is exclusive to the Vesivirus genus, and it is needed for successful feline calicivirus (FCV) replication, as well as an efficient apoptosis induction through the mitochondrial pathway.
Bibiana Chávez-Munguía +2 more
exaly +4 more sources
Virology Journal, 2023 Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–
Ulrike Breitinger +3 more
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Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors [PDF]
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger +3 more
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Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
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Monoclonal antibody 1B9 against the African swine fever virus viroporin pB169L: molecular characterization and epitope mapping [PDF]
Frontiers in MicrobiologyIntroductionThe African swine fever virus (ASFV) viroporin pB169L is a conserved membrane protein, but well-defined reagents for its detection and molecular characterization remain limited.MethodsA soluble recombinant antigen comprising the non ...
Zhiying Cui +23 more
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Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses [PDF]
VirusesCrimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Hiya Lahiri +2 more
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The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication [PDF]
Journal of VirologyFeline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez +7 more
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Membrane Activity and Viroporin Assembly for the SARS-CoV-2 E Protein Are Regulated by Cholesterol
BiomoleculesThe SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to deform cell membranes for viral budding.
Zaret G Denieva +2 more
exaly +3 more sources
Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
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