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Viroporins: emerging viral infection mechanisms and therapeutic targets [PDF]
Journal of VirologyViroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle—from entry and replication to
Yuxin Qu +8 more
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Membrane Activity and Viroporin Assembly for the SARS-CoV-2 E Protein Are Regulated by Cholesterol [PDF]
BiomoleculesThe SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to deform cell membranes for viral budding.
Marta Volovik +2 more
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Viral Membrane Channels: Role and Function in the Virus Life Cycle [PDF]
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
doaj +4 more sources
Poultry Science, 2021 : Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Anchun Cheng, Xumin Ou, Sai Mao
exaly +3 more sources
Vaccines, 2022 To improve the production of foot-and-mouth disease (FMD) molecular vaccines, we sought to understand the effects of the FMD virus (FMDV) 2B viroporin in an experimental, plasmid-based, virus-like particle (VLP) vaccine.
Victoria Primavera +2 more
exaly +3 more sources
Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2 [PDF]
Virology Journal, 2023 Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–
Ulrike Breitinger +3 more
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The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
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Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum [PDF]
Viruses, 2018 We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical
Douglas P. Gladue +8 more
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Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites [PDF]
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
doaj +2 more sources
MSphere, 2019 Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown.
Jacob L Perry +2 more
exaly +3 more sources