Results 11 to 20 of about 4,200 (198)
The SH protein of mumps virus is a druggable pentameric viroporin. [PDF]
Sci AdvViral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing group of virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane.
Devantier K +15 more
europepmc +10 more sources
Vpu Protein: The Viroporin Encoded by HIV-1 [PDF]
Viruses, 2015 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains.
Maria Eugenia Gonzalez
exaly +8 more sources
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
doaj +3 more sources
Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
doaj +4 more sources
Viroporins: emerging viral infection mechanisms and therapeutic targets [PDF]
Journal of VirologyViroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle—from entry and replication to
Yuxin Qu +8 more
doaj +4 more sources
Unveiling the viroporin arsenal in plant viruses: Implications for the future. [PDF]
PLoS PathogViroporins are small, hydrophobic viral proteins that modify cellular membranes to form tiny pores for influx of ions and small molecules. Previously, viroporins were identified exclusively in vertebrate viruses. Recent studies have shown that both plant-
Wu G, Chen J, Wang A, Yan F.
europepmc +5 more sources
Viruses, 2022 The leader of the capsid (LC) protein is exclusive to the Vesivirus genus, and it is needed for successful feline calicivirus (FCV) replication, as well as an efficient apoptosis induction through the mitochondrial pathway.
Ana Gutiérrez-Escolano +1 more
exaly +4 more sources
A hidden gene in astroviruses encodes a viroporin [PDF]
Nature Communications, 2020 Astroviruses are common human pathogens and their genomes contain three known protein-coding genes. Here, Lulla et al. report a fourth, previously overlooked gene encoding protein XP which has a viroporin-like activity that is important for efficient ...
Valeria Lulla, Andrew E. Firth
doaj +19 more sources
Viroporin-like activity of the hairpin transmembrane domain of African swine fever virus B169L protein. [PDF]
J VirolAfrican swine fever virus (ASFV) is the causative agent of a contagious disease affecting wild and domestic swine. The function of B169L protein, as a potential integral structural membrane protein, remains to be experimentally characterized. Using state-
Gladue DP +9 more
europepmc +3 more sources
Vaccines, 2022 To improve the production of foot-and-mouth disease (FMD) molecular vaccines, we sought to understand the effects of the FMD virus (FMDV) 2B viroporin in an experimental, plasmid-based, virus-like particle (VLP) vaccine.
Victoria Primavera +4 more
doaj +2 more sources