The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogensViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus.
Vicken Aknadibossian +5 more
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Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
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A hidden gene in astroviruses encodes a viroporin [PDF]
Nature Communications, 2020 Astroviruses are common human pathogens and their genomes contain three known protein-coding genes. Here, Lulla et al. report a fourth, previously overlooked gene encoding protein XP which has a viroporin-like activity that is important for efficient ...
Valeria Lulla, Andrew E. Firth
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NLRP3 Inflammasome Activation by Viroporins of Animal Viruses [PDF]
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Hui-Chen Guo +4 more
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Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses [PDF]
VirusesCrimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Hiya Lahiri +2 more
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The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication [PDF]
Journal of VirologyFeline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez +7 more
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]
Communications BiologyORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci +9 more
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The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholThe cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
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Computational investigation in inhibitory effects of amantadine on classical swine fever virus p7 ion channel activity [PDF]
Scientific ReportsClassical swine fever virus (CSFV) p7 viroporin plays crucial roles in cellular ion balance and permeabilization. The antiviral drug amantadine effectively inhibits viral replication by blocking the activity of CSFV p7 viroporin.
Xiaowei Chen, Xiao Wang
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Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins. [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins. Several studies have characterized the role of 6K in alphavirus budding and infection since its discovery in the late 1970s.
Negi V, Miller AS, Kuhn RJ.
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