Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K With Well-Characterized Viroporins [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins.
Richard J Kuhn, Vashi Negi
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Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity [PDF]
VirusesViruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins
Moises León-Juárez +2 more
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Viroporins: Emerging Viral Infection Mechanisms and Therapeutic Targets. [PDF]
Journal of VirologyViroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle—from entry and replication to
Hua-Ji Qiu, Su Li, Lian-Feng Li
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Identification and Structural Characterization of Viroporins From Deadly Hemorrhagic Viruses [PDF]
VirusesCrimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Kingshuk Basu +2 more
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The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogensViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus.
Vicken Aknadibossian +5 more
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Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses
Frontiers in Immunology, 2022 Viroporins are virally encoded transmembrane proteins that are essential for viral pathogenicity and can participate in various stages of the viral life cycle, thereby promoting viral proliferation.
Shaqiu Zhang, Qun Gao
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Unveiling the viroporin arsenal in plant viruses: Implications for the future. [PDF]
PLoS PathogensViroporins are small, hydrophobic viral proteins that modify cellular membranes to form tiny pores for influx of ions and small molecules. Previously, viroporins were identified exclusively in vertebrate viruses. Recent studies have shown that both plant-
Guanwei Wu +3 more
doaj +2 more sources
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Viruses, 2015 Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane
Ismael Mingarro, Luis Martinez-Gil
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Role of Ion Channels in the Pathophysiology of SARS-CoV-2 [PDF]
VirusesIn the pathophysiology of SARS-CoV-2, the critical role of ion channels has become increasingly evident during the COVID-19 crisis. This review offers a comprehensive analysis of the functions of ion channels, including viroporins, in both the viral life
Faisal F. Alousi, Abdel A. Alli
doaj +2 more sources
MBio, 2018 Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis.
Raul Fernandez-Delgado +2 more
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