Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity [PDF]
VirusesViruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins
Leticia Cedillo-Barron +2 more
exaly +6 more sources
Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses [PDF]
Frontiers in Immunology, 2022 Viroporins are virally encoded transmembrane proteins that are essential for viral pathogenicity and can participate in various stages of the viral life cycle, thereby promoting viral proliferation.
Xumin Ou, Dekang Zhu, RenYong Jia
exaly +4 more sources
Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins.
Vashi Negi +2 more
doaj +3 more sources
NLRP3 Inflammasome Activation by Viroporins of Animal Viruses [PDF]
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Shiqi Sun
exaly +5 more sources
Viroporins: emerging viral infection mechanisms and therapeutic targets [PDF]
Journal of VirologyViroporins, virus-encoded small hydrophobic proteins, are involved in critical steps of viral infections by modulating ion homeostasis, disrupting host membrane integrity, and orchestrating key stages of the virus life cycle—from entry and replication to
Yuxin Qu +8 more
doaj +4 more sources
The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogensViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus.
Vicken Aknadibossian +5 more
doaj +2 more sources
Viral Membrane Channels: Role and Function in the Virus Life Cycle [PDF]
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
doaj +4 more sources
How many SARS-CoV-2 “viroporins” are really ion channels? [PDF]
Communications Biology, 2022 The SARS-CoV-2 virus uses a small number of viral proteins to enter host cells and disrupt their activity, including the spike (S), membrane (M), and envelope (E) proteins, as well as a number of accessory proteins of unknown function (Orf3a, Orf8, Orf10,
Neil L. Harrison +12 more
doaj +6 more sources
Unveiling the viroporin arsenal in plant viruses: Implications for the future. [PDF]
PLoS PathogensViroporins are small, hydrophobic viral proteins that modify cellular membranes to form tiny pores for influx of ions and small molecules. Previously, viroporins were identified exclusively in vertebrate viruses. Recent studies have shown that both plant-
Guanwei Wu +3 more
doaj +2 more sources
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Viruses, 2015 Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane
Luis Martinez-Gil, Ismael Mingarro
exaly +3 more sources