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Viroporins in the Influenza Virus [PDF]
Cells, 2019 Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A−C known to infect humans.
Janet To, Jaume Torres
exaly +6 more sources
Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction ...
I. Zaloilo +3 more
doaj +2 more sources
Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses [PDF]
VirusesCrimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Hiya Lahiri +2 more
doaj +2 more sources
Impact of Vesicular Stomatitis Virus M Proteins on Different Cellular Functions. [PDF]
PLoS ONE, 2015 Three different matrix (M) proteins termed M1, M2 and M3 have been described in cells infected with vesicular stomatitis virus (VSV). Individual expression of VSV M proteins induces an evident cytopathic effect including cell rounding and detachment, in ...
Natalia Redondo +3 more
doaj +6 more sources
MBio, 2018 Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis.
Javier Gutiérrez-Álvarez +2 more
exaly +3 more sources
The SH protein of mumps virus is a druggable pentameric viroporin. [PDF]
Sci AdvViral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing groupof virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane.Despite sparsity in ...
Devantier K +15 more
europepmc +3 more sources
Viruses, 2015 Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
Jaume Torres
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A BSL-2 chimeric system designed to screen SARS-CoV-2 E protein ion channel inhibitors [PDF]
Journal of VirologyA major hindrance to the identification of new drug targets and the large-scale testing of new or existing compound libraries against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is that research on the virus is restricted to biosafety ...
Vashi Negi, Richard J. Kuhn
doaj +2 more sources
Viruses, 2015 Viroporins are members of a rapidly growing family of channel-forming small polypeptides found in viruses. The present review will be focused on recent structural and protein-protein interaction information involving two viroporins found in enveloped ...
Jaume Torres, Wahyu Surya, Yan Li
exaly +3 more sources
Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]
Viruses, 2015 Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Luis Nieva, Luis Carrasco
doaj +5 more sources