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Viroporins in the Influenza Virus [PDF]
Cells, 2019 Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A−C known to infect humans.
Janet To, Jaume Torres
exaly +7 more sources
Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction ...
I. Zaloilo +3 more
doaj +3 more sources
Searching for Blockers of Dengue and West Nile Virus Viroporins [PDF]
Viruses, 2022 Flavivirus infections, such as those caused by dengue and West Nile viruses, emerge as new challenges for the global healthcare sector. It has been found that these two viruses encode ion channels collectively termed viroporins. Therefore, drug molecules
Hiya Lahiri, Isaiah T. Arkin
doaj +5 more sources
Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]
Viruses, 2015 Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Luis Nieva, Luis Carrasco
doaj +7 more sources
Viruses, 2015 Viroporins are members of a rapidly growing family of channel-forming small polypeptides found in viruses. The present review will be focused on recent structural and protein-protein interaction information involving two viroporins found in enveloped ...
Jaume Torres +2 more
exaly +4 more sources
Viruses, 2015 Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung +2 more
exaly +4 more sources
Pharmacological ResearchA class of proteins encoded by viral genomes, referred to as viroporins, is composed of small hydrophobic proteins that form pores or ion channels in host membranes. These proteins modulate the viral life cycle and pathogenicity.
Zhaobing Gao, Bingqing Xia
exaly +4 more sources
Targeting Host Calcium Channels and Viroporins: A Promising Strategy for SARS-CoV-2 Therapy [PDF]
Future Virology, 2023 Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option.
Mona Fani +2 more
exaly +3 more sources
Viroporins of Mpox Virus. [PDF]
Int J Mol Sci, 2023 Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore,
Basu K, Krugliak M, Arkin IT.
europepmc +4 more sources
Viroporins: Structure and biological functions [PDF]
Nature Reviews Microbiology, 2015 Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of ...
Madan, Vanesa +2 more
core +5 more sources