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Viroporins in the Influenza Virus
Cells, 2019 Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A−C known to infect humans.
Janet To, Jaume Torres
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Pharmacological ResearchA class of proteins encoded by viral genomes, referred to as viroporins, is composed of small hydrophobic proteins that form pores or ion channels in host membranes. These proteins modulate the viral life cycle and pathogenicity.
Zhaobing Gao, Bingqing Xia
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Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction ...
I. Zaloilo +3 more
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Targeting Host Calcium Channels and Viroporins: A Promising Strategy for SARS-CoV-2 Therapy [PDF]
Future Virology, 2023 Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option.
Mona Fani +2 more
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NLRP3 Inflammasome Activation by Viroporins of Animal Viruses
Viruses, 2015 Viroporins are a group of low-molecular-weight proteins containing about 50–120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly ...
Hui-Chen Guo +4 more
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Viruses, 2015 Viroporins are members of a rapidly growing family of channel-forming small polypeptides found in viruses. The present review will be focused on recent structural and protein-protein interaction information involving two viroporins found in enveloped ...
Jaume Torres +3 more
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Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]
Viruses, 2015 Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Luis Nieva, Luis Carrasco
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Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease
Viruses, 2021 The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development of novel vaccines and much needed
Siobhan Gargan, Nigel J. Stevenson
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Viruses, 2015 Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung +2 more
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Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis [PDF]
Viruses, 2015 Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming
Jose L. Nieto-Torres +4 more
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