Results 41 to 50 of about 1,355 (133)
Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome
Frontiers in Immunology, 2020 Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava +8 more
doaj +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, Volume 13, Issue 42, 28 July 2026.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links
Cancer Reports, Volume 9, Issue 7, July 2026.ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue +2 more
wiley +1 more source
Viroporins: Structure, function and potential as antiviral targets [PDF]
, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed ‘viroporins’ is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these ...
Griffin, S, Scott, C
core +1 more source
Viral Membrane Channels: Role and Function in the Virus Life Cycle
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
doaj +1 more source
iNew Medicine, Volume 2, Issue 2, June 2026.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells. [PDF]
Cell Death DiscovInflammasome assembly is a potent mechanism responsible for the host protection against pathogens, including viruses. When compromised, it can allow viral replication, while when disrupted, it can perpetuate pathological responses by IL-1 signaling and ...
Ambrożek-Latecka M +13 more
europepmc +2 more sources
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5
MedComm, Volume 7, Issue 6, June 2026.The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie +9 more
wiley +1 more source
SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release
mLife, Volume 5, Issue 3, Page 339-354, June 2026.Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin +7 more
wiley +1 more source
Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take?
Frontiers in Chemistry, 2021 Pore-forming proteins (PFPs) exist in virtually all domains of life, and by disrupting cellular membranes, depending on the pore size, they cause ion dis-balance, small substances, or even protein efflux/influx, influencing cell’s signaling routes and ...
Eva Žerovnik
doaj +1 more source