Results 41 to 50 of about 1,807 (187)
SARS-CoV-2 E and 3a Proteins Are Inducers of Pannexin Currents
Cells, 2023 Controversial reports have suggested that SARS-CoV E and 3a proteins are plasma membrane viroporins. Here, we aimed at better characterizing the cellular responses induced by these proteins. First, we show that expression of SARS-CoV-2 E or 3a protein in
Barbara B. R. Oliveira-Mendes +10 more
doaj +1 more source
A hidden gene in astroviruses encodes a viroporin [PDF]
Nature Communications, 2020 Abstract Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children worldwide and have been associated with encephalitis and meningitis in immunocompromised individuals.
Lulla, Valeria, Firth, Andrew E.
openaire +4 more sources
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis [PDF]
, 2014 Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function in virus-host interaction.
Aguilella, Vicente +10 more
core +6 more sources
Retrovirology, 2022 Background Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for viroporins.
Wyatt Henke +4 more
doaj +1 more source
Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis
Viruses, 2015 Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming
Jose L. Nieto-Torres +4 more
doaj +1 more source
DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71 [PDF]
, 2011 published_or_final_versio
Jin, Q +9 more
core +4 more sources
Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein [PDF]
, 2007 Background Mechanisms by which HIV-1 mediates reductions in CD4+ cell levels in infected persons are being intensely investigated, and have broad implications for AIDS drug and vaccine development.
Joshua M Costin +3 more
core +2 more sources
A metastasis-associated pannexin-1 mutant (Panx1<sup>1-89</sup>) forms a minimalist ATP release channel. [PDF]
FEBS JA truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Wang J +5 more
europepmc +2 more sources
Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]
Microbial Physiology, 2022 Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler +3 more
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Ebola Virus Delta Peptide Is a Viroporin [PDF]
Journal of Virology, 2017 ABSTRACT The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD). The function of the delta peptide is unknown, but sequence analysis has suggested that delta peptide could be a viroporin, belonging to a diverse ...
Jing, He +11 more
openaire +2 more sources