Results 41 to 50 of about 1,345 (158)

How many SARS-CoV-2 “viroporins” are really ion channels?

Communications Biology, 2022
The SARS-CoV-2 virus uses a small number of viral proteins to enter host cells and disrupt their activity, including the spike (S), membrane (M), and envelope (E) proteins, as well as a number of accessory proteins of unknown function (Orf3a, Orf8, Orf10,
Neil L. Harrison, Geoffrey W. Abbott, Martina Gentzsch, Andrei Aleksandrov, Anna Moroni, Gerhard Thiel, Stephen Grant, Colin G. Nichols, Henry A. Lester, Andreas Hartel, Kenneth Shepard, David Cabrera Garcia, Masayuki Yazawa   +12 more
doaj   +2 more sources

The role of severe acute respiratory syndrome coronavirus 2 viroporins in inflammation

Advances in Human Biology, 2022
In December 2019, genomic screening of clinical samples from patients with viral pneumonia in Wuhan, China, revealed the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Arghavan Zebardast, Tayebeh Latifi, Jila Yavarian   +2 more
doaj   +1 more source

Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]

Microbial Physiology, 2022
Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler, Kevin J. Hendargo, Arturo Medrano-Soto, Milton H. Saier   +3 more
openaire   +2 more sources

Reply to: How Many SARS-CoV-2 “Viroporins” Are Really Ion Channels? [PDF]

Communications Biology, 2022
Trine L. Toft-Bertelsen, Mads Gravers Jeppesen, Asante Landbrug, Amer Mujezinovic, Bo Hjorth Bentzen, Thomas Nitschke Kledal, Mette Marie Rosenkilde   +6 more
doaj   +2 more sources

Membrane Integration of Poliovirus 2B Viroporin [PDF]

Journal of Virology, 2011
ABSTRACT Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family. Prototypical viroporin 2B is responsible for the alterations in host cell membrane permeability that take place in enterovirus-infected cells. 2B protein
Martínez Gil, Luis, Bañó Polo, Manuel, Redondo, Natalia, Sánchez Martínez, Silvia, Nieva, José Luis, Carrasco, Luis, Mingarro Muñoz, Ismael   +6 more
openaire   +5 more sources

Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors

Frontiers in Microbiology, 2021
Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger, Nourhan K. M. Ali, Heinrich Sticht, Hans-Georg Breitinger   +3 more
doaj   +1 more source

The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)

Retrovirology, 2022
Background Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for viroporins.
Wyatt Henke, Hope Waisner, Sachith Polpitiya Arachchige, Maria Kalamvoki, Edward Stephens   +4 more
doaj   +1 more source

Ebola Virus Delta Peptide Is a Viroporin [PDF]

Journal of Virology, 2017
ABSTRACT The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD). The function of the delta peptide is unknown, but sequence analysis has suggested that delta peptide could be a viroporin, belonging to a diverse ...
Jing, He, Lilia I, Melnik, Alexander, Komin, Gregory, Wiedman, Taylor, Fuselier, Cameron F, Morris, Charles G, Starr, Peter C, Searson, William R, Gallaher, Kalina, Hristova, Robert F, Garry, William C, Wimley   +11 more
openaire   +2 more sources

Viroporin-mediated calcium-activated autophagy [PDF]

Autophagy, 2013
Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
openaire   +2 more sources

The SH protein of mumps virus is a druggable pentameric viroporin. [PDF]

Sci Adv
Viral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing group of virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane.
Devantier K, Toft-Bertelsen TL, Prestel A, Kjær VMS, Sahin C, Giulini M, Louka S, Spiess K, Manandhar A, Qvortrup K, Ulven T, Bentzen BH, Bonvin AM, MacAulay N, Kragelund BB, Rosenkilde MM.   +15 more
europepmc   +6 more sources