Results 51 to 60 of about 1,355 (133)

SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore

Frontiers in Immunology, 2023
BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri, Alessia Angelin, Deborah G. Murdock, Patrick Schaefer, Prasanth Portluri, Timothy Lie, Timothy Lie, Jessica Huang, Douglas C. Wallace, Douglas C. Wallace   +9 more
doaj   +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +1 more source

Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu. [PDF]

Biochemistry
Viroporins constitute a class of viral membrane proteins with diverse roles in the viral life cycle. They can self-assemble and form pores within the bilayer that transport substrates, such as ions and genetic material, that are critical to the viral ...
Townsend JA, Fapohunda O, Wang Z, Pham H, Taylor MT, Kloss B, Park SH, Opella S, Aspinwall CA, Marty MT.   +9 more
europepmc   +2 more sources

The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola, Md Majharul Islam, Elaheh Hadadianpour, Peter P. Borbat, Adeyemi Ogunbowale, Juan C. R. Amador, Elka R. Georgieva   +6 more
wiley   +1 more source

Viroporins: Structure and biological functions

, 2015
Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of ...
Madan, Vanesa, Nieva, José Luis, Carrasco Llamas, Luis   +2 more
core   +1 more source

A universal cell-based method for high-throughput analysis of viroporin function and inhibition

Pharmacological Research
Viroporins are transmembrane proteins encoded mainly by RNA viruses that oligomerize to form pores essential for multiple stages of the viral life cycle.
Viktoria M.S. Kjær, Felix Faas, Bo H. Bentzen, Mette M. Rosenkilde   +3 more
doaj   +1 more source

Assessing the Impact of Colchicine on Pulmonary Fibrosis Using Imaging in Patients With Moderate‐to‐Severe COVID‐19 Pneumonia

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak, Mustafa Ilteris Bardakci, Ugur Temel, Karuna Sharma   +3 more
wiley   +1 more source

Porcine Rotavirus NSP4 Inhibits Type I Interferon Production via NRBF2‐Mediated Autophagic Degradation of MDA‐5

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The type I interferon (IFN‐I) signaling pathway plays a pivotal role in orchestrating antiviral innate immune defenses, particularly during the clearance of invading pathogens. Rotaviruses have evolved a repertoire of viral proteins to counteract host immune surveillance. While certain functions of rotavirus nonstructural proteins in antagonizing IFN‐I
Jiaxing Zhan, Tianhao Liang, Jiale Chen, Jingying Wang, Enqi Dai, Ting Wang, Shaojie Wang, Zixuan Cao, Hanwei Jiao, Yan Zeng, Chunfeng Wang, Xin Cao, Linzhu Ren   +12 more
wiley   +1 more source

Celastrol Suppresses Porcine Deltacoronavirus Replication by Modulating Endoplasmic Reticulum Stress‐Associated Ca2+ Balance

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine deltacoronavirus (PDCoV) infection causes watery diarrhea and even death in neonatal piglets, leading to substantial economic losses. Meanwhile, emerging evidence indicates the potential risk of PDCoV to threaten human health and public safety. However, the effective vaccines or medicines are deficient.
Jialu Zhang, Yuqian Liu, Letao Gao, Wenzhe Liu, Ru Yan, Die Zhu, Zhouyuan Wang, Lianci Peng, Rendong Fang, Tingting Chen, Bin Li   +10 more
wiley   +1 more source