Results 51 to 60 of about 1,466 (157)
Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]
FEBS Letters, 2003 Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L. +3 more
openaire +2 more sources
Impact of histidine residues on the transmembrane helices of viroporins [PDF]
Molecular Membrane Biology, 2013 Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan +3 more
openaire +4 more sources
Addressing SARS-CoV-2 viroporins with antiarrhythmic drugs. [PDF]
EuropaceBloothooft M, Voigt N, de Boer TP.
europepmc +4 more sources
The FEBS Journal, EarlyView.RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas +4 more
wiley +1 more source
Liver International, Volume 46, Issue 12, December 2026.ABSTRACT Background and Aims Hepatitis E virus (HEV) infection is becoming increasingly clinically relevant worldwide, but no approved antiviral therapy currently exists. Ribavirin (RBV) is used off‐label for immunosuppressed patients with chronic hepatitis E, although it is effective in only 80% of patients and linked to side effects.
Annika Volmari +6 more
wiley +1 more source
SARS-CoV-2 Viroporins: A Multi-Omics Insight from Nucleotides to Amino Acids
, 2022 COVID-19 is caused by SARS-CoV-2 which has so far affected more than 500 million people worldwide and killed over 6 million as of 1 May 2022. The approved emergency-use vaccines were lifesaving in such a devastating pandemic.
Soham Saha +3 more
core +1 more source
Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu. [PDF]
BiochemistryViroporins constitute a class of viral membrane proteins with diverse roles in the viral life cycle. They can self-assemble and form pores within the bilayer that transport substrates, such as ions and genetic material, that are critical to the viral ...
Townsend JA +9 more
europepmc +2 more sources
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
Viruses, 2010 The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus ...
Eike Steinmann, Thomas Pietschmann
doaj +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella +10 more
wiley +1 more source