Pathophysiological Consequences of Calcium-Conducting Viroporins [PDF]
Annual Review of Virology, 2015 Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain and regulate transmembrane ion gradients. As intracellular parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt normal ionic homeostasis to promote viral replication and pathogenesis.
Joseph M, Hyser, Mary K, Estes
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Addressing SARS-CoV-2 viroporins with antiarrhythmic drugs. [PDF]
EuropaceBloothooft M, Voigt N, de Boer TP.
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Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]
FEBS Letters, 2003 Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L. +3 more
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A metastasis-associated pannexin-1 mutant (Panx1<sup>1-89</sup>) forms a minimalist ATP release channel. [PDF]
FEBS JA truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Wang J +5 more
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Impact of histidine residues on the transmembrane helices of viroporins [PDF]
Molecular Membrane Biology, 2013 Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan +3 more
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SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells. [PDF]
Cell Death DiscovInflammasome assembly is a potent mechanism responsible for the host protection against pathogens, including viruses. When compromised, it can allow viral replication, while when disrupted, it can perpetuate pathological responses by IL-1 signaling and ...
Ambrożek-Latecka M +13 more
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Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome
Frontiers in Immunology, 2020 Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava +8 more
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In Situ Spectroscopic Detection of Large‐Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening [PDF]
, 2023 Viroporins are small ion channels in membranes of enveloped viruses that play key roles during viral life cycles. To use viroporins as drug targets against viral infection requires in-depth mechanistic understanding and, with that, methods that enable ...
Paschke, Ronja Rabea +4 more
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SARS-CoV-2 Viroporins: A Multi-Omics Insight from Nucleotides to Amino Acids
, 2022 COVID-19 is caused by SARS-CoV-2 which has so far affected more than 500 million people worldwide and killed over 6 million as of 1 May 2022. The approved emergency-use vaccines were lifesaving in such a devastating pandemic.
Soham Saha +3 more
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Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu. [PDF]
BiochemistryViroporins constitute a class of viral membrane proteins with diverse roles in the viral life cycle. They can self-assemble and form pores within the bilayer that transport substrates, such as ions and genetic material, that are critical to the viral ...
Townsend JA +9 more
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