Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B [PDF]
, 2018 Nonstructural protein 2B of foot-and-mouth disease (FMD) virus (FMDV) is comprised of a small, hydrophobic, 154-amino-acid protein. Structure-function analyses demonstrated that FMDV 2B is an ion channel-forming protein.
Aguilella, Vicente +13 more
core +1 more source
The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2 [PDF]
, 2013 10.1016/j.virusres.2012.12.005Virus Research 1721-224 ...
Aweya, Jude Juventus +3 more
core +1 more source
Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses [PDF]
, 2018 Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain of the Classical Swine Fever ...
Aguilella, Vicente +6 more
core +2 more sources
The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility [PDF]
, 2018 Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K⁺ and Cl⁻ channels now being ...
Adrian Whitehouse +49 more
core +2 more sources
COVID-19, Cation Dysmetabolism, Sialic Acid, CD147, ACE2, Viroporins, Hepcidin and Ferroptosis: A Possible Unifying Hypothesis [PDF]
, 2022 Background: iron and calcium dysmetabolism, with hyperferritinemia, hypoferremia, hypocalcemia and anemia have been documented in the majority of COVID-19 patients at later/worse stages. Furthermore, complementary to ACE2, both sialic acid (SA) molecules
Attilio Cavezzi +3 more
core +1 more source
Unusual architecture of the p7 channel from hepatitis C virus [PDF]
, 2014 The Hepatitis C virus (HCV) has developed a small membrane protein, p7, which remarkably can self-assemble into a large channel complex that selectively conducts cations1-4.
Berardi, Marcelo J. +7 more
core +1 more source
Viroporins from RNA viruses induce caspase-dependent apoptosis [PDF]
Cellular Microbiology, 2007 The virus-encoded viroporins are known to modify membrane permeability and play an essential role in virus budding. Here, a comparative analysis of the membrane permeabilization capacity of a number of viroporins was performed in baby hamster kidney cells.
Vanessa, Madan +2 more
openaire +2 more sources
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage [PDF]
, 2009 Cytopathic viruses have developed successful strategies to block or, at least, to attenuate host interference with their replication. Here, we have analyzed the effects of poliovirus 2A protease on RNA nuclear export.
Carrasco Llamas, Luis +3 more
core +1 more source
Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]
DNA and Cell Biology, 2013 Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire +2 more sources
Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production [PDF]
, 2018 Large scale continuous cell‐line cultures promise greater reproducibility and efficacy for the production of influenza vaccines, and adenovirus for gene therapy.
Altaras +48 more
core +2 more sources