Results 71 to 80 of about 1,345 (158)
The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba +4 more
wiley +1 more source
Analysis of Viroporins and Membrane Systems With Native Mass Spectrometry
, 2023 Viroporins are a class of viral membrane proteins that play diverse roles in the viral infection cycle. Viroporins are known to play roles in ion transport, inducing membrane curvature, as well as participating in a variety of protein-protein ...
Townsend, Julia
core
The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin
Protein Science, Volume 35, Issue 2, February 2026.Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola +6 more
wiley +1 more source
Viroporin activity of murine hepatitis virus E protein [PDF]
FEBS Letters, 2005 The viroporin activity of the E protein from murine hepatitis virus (MHV), a member of the coronaviruses, was analyzed. Viroporins are a growing family of viral proteins able to enhance membrane permeability, promoting virus budding. Initially, the MHV E gene was inducibly expressed in Escherichia coli cells, leading to the arrest of bacterial growth ...
Madan, Vanessa +3 more
openaire +2 more sources
Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak +3 more
wiley +1 more source
Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]
DNA and Cell Biology, 2013 Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire +2 more sources
Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin
Viruses, 2015 The high prevalence of hepatitis C virus (HCV) infection in the human population has triggered intensive research efforts that have led to the development of curative antiviral therapy.
Vanesa Madan, Ralf Bartenschlager
doaj +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.The type I interferon (IFN‐I) signaling pathway plays a pivotal role in orchestrating antiviral innate immune defenses, particularly during the clearance of invading pathogens. Rotaviruses have evolved a repertoire of viral proteins to counteract host immune surveillance. While certain functions of rotavirus nonstructural proteins in antagonizing IFN‐I
Jiaxing Zhan +12 more
wiley +1 more source
Vpu Protein: The Viroporin Encoded by HIV-1 [PDF]
Viruses, 2015 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins.
openaire +4 more sources
Targeting Viral Ion Channels: A Promising Strategy to Curb SARS-CoV-2
Pharmaceuticals, 2022 SARS-CoV-2 is the etiological agent COVID-19, one of the most impactful health crises afflicting humanity in recent decades. While research advances have yielded several treatment and prevention options, the pandemic is slow to abate, necessitating an ...
Anamika Singh, Isaiah T. Arkin
doaj +1 more source