Results 71 to 80 of about 1,807 (187)
Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein [PDF]
, 2021 Acknowledgments: The authors would like to gratefully acknowledge the efforts of Julia Martinez Fraile, Richard Lofthouse, Lewis Penny, Mohammad Arastoo and Natalia Cattelan for providing training and assistance with various experimental procedures ...
Corzo-Leon, Dora E. +5 more
core +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Viroporin activity of murine hepatitis virus E protein [PDF]
FEBS Letters, 2005 The viroporin activity of the E protein from murine hepatitis virus (MHV), a member of the coronaviruses, was analyzed. Viroporins are a growing family of viral proteins able to enhance membrane permeability, promoting virus budding. Initially, the MHV E gene was inducibly expressed in Escherichia coli cells, leading to the arrest of bacterial growth ...
Madan, Vanessa +3 more
openaire +2 more sources
Viruses, 2014 To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment.
Eva Bilkova +2 more
doaj +1 more source
iNew Medicine, EarlyView.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Zika M—A Potential Viroporin: Mutational Study and Drug Repurposing
Biomedicines, 2022 Genus Flavivirus contains several important human pathogens. Among these, the Zika virus is an emerging etiological agent that merits concern. One of its structural proteins, prM, plays an essential role in viral maturation and assembly, making it an attractive drug and vaccine development target.
Prabhat Pratap Singh Tomar +3 more
openaire +3 more sources
Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take?
Frontiers in Chemistry, 2021 Pore-forming proteins (PFPs) exist in virtually all domains of life, and by disrupting cellular membranes, depending on the pore size, they cause ion dis-balance, small substances, or even protein efflux/influx, influencing cell’s signaling routes and ...
Eva Žerovnik
doaj +1 more source
In: Fischer W.B. (eds) Viral Membrane Proteins: Structure, Function, and Drug Design. [PDF]
, 2005 This chapter is devoted to reviewing some characteristics of membrane permeabilization by viral proteins. In addition, the methodology used to assay enhanced permeability in animal cells is described.
Carrasco, Luis, Gonzalez, Maria Eugenia
core +2 more sources
Structural biology of coronavirus ion channels [PDF]
, 2021 Viral infection compromises specific organelles of the cell and readdresses its functional resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive-sense single-stranded RNA encodes proteins involved in replication, and
Barrantes, Francisco Jose
core +1 more source
The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba +4 more
wiley +1 more source