Results 71 to 80 of about 1,355 (133)
Role of Ion Channels in the Pathophysiology of SARS-CoV-2
VirusesIn the pathophysiology of SARS-CoV-2, the critical role of ion channels has become increasingly evident during the COVID-19 crisis. This review offers a comprehensive analysis of the functions of ion channels, including viroporins, in both the viral life
Faisal F. Alousi, Abdel A. Alli
doaj +1 more source
The Interplay Between Viral Infection and Cell Death: A Ping‐Pong Effect
Advances in Virology, Volume 2025, Issue 1, 2025.Programmed cell death (PCD) is a well‐studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival.
Alireza Nourazarian +5 more
wiley +1 more source
Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays
Viruses, 2019 Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar +3 more
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Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds
, 2020 [Figure not available: see fulltext.] Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new ...
Shiryaev Vadim A.
core
Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.
PLoS ONE, 2015 Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao +10 more
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Investigation of HMA derivatives as small molecule inhibitors of viroporins
, 2023 Seasonal and pandemic viral infections continue to pose severe challenges to human health. Antivirals that can effectually complement current vaccination strategies are vital in the battle against drug-resistant pandemic viral strains.
Jalily Hasani, Pouria
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MoleculesThe emergence of drug-resistant influenza virus strains necessitates the development of novel antiviral agents with unique mechanisms of action. This study presents the synthesis and in vitro evaluation of a new class of antiviral compounds: sodium salts
Timur M. Garaev +9 more
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The effect of amantadine on an ion channel protein from Chikungunya virus.
PLoS Neglected Tropical Diseases, 2019 Viroporins like influenza A virus M2, hepatitis C virus p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, and create hydrophilic corridors, which are critical for viral entry, replication and egress.
Debajit Dey +7 more
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The human polyoma JC virus agnoprotein acts as a viroporin.
PLoS Pathogens, 2010 Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Tadaki Suzuki +8 more
doaj +1 more source
Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review X [PDF]
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression
Griffin, Stephen +9 more
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