Results 81 to 90 of about 1,807 (187)
Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak +3 more
wiley +1 more source
Targeting the Channel Activity of Viroporins
, 2016 Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the ...
To, Janet, Surya, Wahyu, Torres, Jaume
openaire +2 more sources
eLife, 2020 Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw +21 more
doaj +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
NS2A comprises a putative viroporin of Dengue virus 2 [PDF]
Virulence, 2017 During infection with Dengue virus (DENV), host cells undergo a series of detrimental functional changes, including profound remodelling and redistribution of cell membrane structures,1,4 which giv...
Gaurav, Shrivastava +6 more
openaire +2 more sources
Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin
Viruses, 2015 The high prevalence of hepatitis C virus (HCV) infection in the human population has triggered intensive research efforts that have led to the development of curative antiviral therapy.
Vanesa Madan, Ralf Bartenschlager
doaj +1 more source
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19 [PDF]
, 2021 Critical to viral infection are the multiple interactions between viral proteins and host-cell counterparts. The first such interaction is the recognition of viral envelope proteins by surface receptors that normally fulfil other physiological roles, a ...
Barrantes, Francisco Jose
core +1 more source
, 2015 Virus encoded ion channels, termed viroporins, are expressed by a diverse set of viruses and have been found to target nearly every host cell membrane and compartment, including endocytic/exocytic vesicles, ER, mitochondria, Golgi, and the plasma membrane. Viroporins are generally very small (
openaire +1 more source
Vpu Protein: The Viroporin Encoded by HIV-1 [PDF]
Viruses, 2015 Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins.
openaire +4 more sources
The SAT Protein of the Minute Virus of Mice Induces the Lysis of the Cell through the Formation of Viroporin-like Structures [PDF]
, 2021 The prototype minute virus of mice (MVMp) and the H-1 virus belong to the family of Parvoviridae and can be used as oncolytic agents that infect, replicate in and kill human cancer cells. In preclinical trials the viruses were shown to be very successful
Bretscher, Clemens
core +1 more source