Results 61 to 70 of about 1,807 (187)

Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome

Frontiers in Immunology, 2020
Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava, Giovani Visoso-Carvajal, Julio Garcia-Cordero, Moisés Leon-Juarez, Bibiana Chavez-Munguia, Tomas Lopez, Porfirio Nava, Nicolás Villegas-Sepulveda, Leticia Cedillo-Barron   +8 more
doaj   +1 more source

Membrane binding proteins of coronaviruses [PDF]

, 2019
Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of severities. Their members include zoonotic viruses with pandemic potential where therapeutic options are currently limited.
Entedar A J Alsaadi, Ian M Jones, Klumperman J, Millet JK   +3 more
core   +1 more source

Modulation of potassium channels inhibits bunyavirus infection [PDF]

, 2015
Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity.
Adams, Bagal, Barr, Barry, Baxter, Becchetti, Bowen, Bridgen, Briese, Briese, Bräuner, Buchholz, Carlton-Smith, Carvalho, Cheng, Crotty, Davis, Dong, Dowall, Dwivedi, Eleftherianos, Elliott, Elliott, Elliott, Enyedi, Evangelista, Feron, Feske, Fontana, Frugulhetti, Goldstein, Goldstein, Goller, Hoffmann, Hollidge, Hsu, Hu, Igloi, Irvine, Jiang, Kaakkola, Kainulainen, Kohl, Kudo, Lang, Lesage, Maltezou, Mankouri, Mankouri, Mathie, Meier, Miller, Murphy, Musset, Nieva, Novoa, Peluffo, Sakurai, Sanchez, Schoen, Shi, Shin, Shtanko, Tauro, Walter, Weber, Wicher, Windley, Wu, Zhang, Zhang   +70 more
core   +4 more sources

Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]

FEBS Letters, 2003
Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L., Agirre, Aitziber, Nir, Shlomo, Carrasco, Luis   +3 more
openaire   +2 more sources

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

PLoS Pathogens, 2012
Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito, Yusuke Yanagi, Takeshi Ichinohe   +2 more
openaire   +4 more sources

Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral Therapy

Viruses, 2010
The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus ...
Eike Steinmann, Thomas Pietschmann
doaj   +1 more source

Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies

Viruses, 2021
Evidence is emerging that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect various organs of the body, including cardiomyocytes and cardiac endothelial cells in the heart.
Huyen Tran Ho, Stefan Peischard, Nathalie Strutz-Seebohm, Karin Klingel, Guiscard Seebohm   +4 more
doaj   +1 more source

Enhanced Patch-Clamp Technique to Study Antimicrobial Peptides and Viroporins, Inserted in a Cell Plasma Membrane with Fully Inactivated Endogenous Conductances [PDF]

, 2012
Many short peptides selectively permeabilize the bacteria plasma membrane, leading to their lyses and death: they are therefore a source of antibacterial molecules, and inspiration for novel and more selective drugs. Another class of short (
Alberto Milani, Giorgio Rispoli, Marco Aquila, Mascia Benedusi   +3 more
core   +1 more source

Membrane-Active Peptides Derived from Picornavirus 2B Viroporin

Current Protein & Peptide Science, 2012
Viruses have evolved membrane-restructuring mechanisms for sustaining entry into cells, genome replication and release from host cells. Picornavirus 2B, a non-structural protein required for effective viral replication, functions as a potent intracellular pore-forming toxin by altering the permeability of cellular endomembranes.
Sánchez-Martínez, Silvia, Madan, Vanesa, Carrasco Llamas, Luis, Nieva, José Luis   +3 more
openaire   +3 more sources

HIV-1 Vpu Protein Mediates the Transport of Potassium in Saccharomyces cerevisiae [PDF]

, 2013
Human immunodeficiency virus type 1 (HIV-1) Vpu is an integral membrane protein that belongs to the viroporin family. Viroporins interact with cell membranes, triggering membrane permeabilization and promoting release of viral particles.
Arino J., Bill R. M., Bolduan S., Burke D., Cesareni G., Cohen E. A., Ewart G. D., Ewart G. D., Ewart G. D., Fischer W. B., Gazzarrini S., Gonzalez M. E., Gonzalez M. E., Gonzalez M. E., Grice A. L., Griffin S. D., Hahn B. H., Hasenbrink G., Hsu K., Hsu K., Huang D. T., Khoury G., Klimkait T., Ko C. H., Kuhl B. D., Kukol A., Kurtz S., Lamb R. A., Laura Herrero, Madan V., Madrid R., Maldarelli F., María Eugenia González, Moore P. B., Nakamura R. L., Neil S. J., Neil S. J., Nieva J. L., Noemí Monroy, Perez-Valle J., Perlin D. S., Pinto L. H., Plugge B., Rodriguez-Navarro A., Ruiz A., Sambrook J., Schubert U., Sychrova H., Thomas B. J., Varela J. C., Wang K., Wilson L.   +51 more
core   +2 more sources