Results 91 to 100 of about 1,345 (158)

Viroporins and inflammasomes: A key to understand virus-induced inflammation

The International Journal of Biochemistry & Cell Biology, 2020
Viroporins are virus encoded proteins that alter membrane permeability and can trigger subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a hydrophilic pore which facilitates ion transport across host cell membranes.
Farag, N.S., Breitinger, U., Breitinger, H.G., El Azizi, M.A.   +3 more
openaire   +2 more sources

Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays

Viruses, 2019
Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar, Rivka Oren, Miriam Krugliak, Isaiah T. Arkin   +3 more
doaj   +1 more source

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.

PLoS ONE, 2015
Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao, Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, To Sing Fung, Yan-Quan Wei, Shi-Chong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding Xiang Liu, Xiang-Tao Liu   +10 more
doaj   +1 more source

Long‐term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged.
Laetitia Gay, Valérie Desquiret‐Dumas, Nicolas Nagot, Clara Rapenne, Philippe Van de Perre, Pascal Reynier, Jean‐Pierre Molès   +6 more
wiley   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

The effect of amantadine on an ion channel protein from Chikungunya virus.

PLoS Neglected Tropical Diseases, 2019
Viroporins like influenza A virus M2, hepatitis C virus p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, and create hydrophilic corridors, which are critical for viral entry, replication and egress.
Debajit Dey, Shumaila Iqbal Siddiqui, Prabhudutta Mamidi, Sukanya Ghosh, Chandra Shekhar Kumar, Soma Chattopadhyay, Subhendu Ghosh, Manidipa Banerjee   +7 more
doaj   +1 more source

Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family [PDF]

, 2014
International audienceViroporins are a group of transmembrane proteins with low molecular weight that are encoded by many animal viruses. Generally, viroporins are composed of 50-120 amino acid residues and possess a minimum of one hydrophobic region ...
Hui-Chen Guo, Ao, Da, Sun, Shi-Qi, Guo, Hui-Chen, Da Ao, Shi-Qi Sun   +5 more
core   +1 more source

Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease

, 2022
The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development of novel vaccines and much needed
Siobhan Gargan (11907946), Nigel Stevenson (12597031)   +1 more
core   +1 more source

Exploring the Anti-Influenza Activity of closo-Borate Platforms: Structure–Activity Relationship of Amino Acid-Functionalized closo-Dodecaborate Derivatives Against Influenza Virus A/Cheboksary/125/2020 (H1N1)pdm09

Molecules
The emergence of drug-resistant influenza virus strains necessitates the development of novel antiviral agents with unique mechanisms of action. This study presents the synthesis and in vitro evaluation of a new class of antiviral compounds: sodium salts
Timur M. Garaev, Ilya I. Yudin, Natalya V. Breslav, Tatyana V. Grebennikova, Evgenii Yu. Matveev, Elizaveta A. Eshtukova-Shcheglova, Ilya E. Sokolov, Varvara V. Avdeeva, Konstantin Yu. Zhizhin, Nikolai T. Kuznetsov   +9 more
doaj   +1 more source

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

PLoS Pathogens, 2012
Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito, Yusuke Yanagi, Takeshi Ichinohe   +2 more
openaire   +4 more sources