Results 111 to 120 of about 1,807 (187)

Viroporins and inflammasomes: A key to understand virus-induced inflammation

The International Journal of Biochemistry & Cell Biology, 2020
Viroporins are virus encoded proteins that alter membrane permeability and can trigger subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a hydrophilic pore which facilitates ion transport across host cell membranes.
Farag, N.S., Breitinger, U., Breitinger, H.G., El Azizi, M.A.   +3 more
openaire   +2 more sources

Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection

Hepatology Research, Volume 54, Issue 8, Page 1-30, August 2024.
Abstract Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to ...
Tatsuo Kanda, Tian‐Cheng Li, Masaharu Takahashi, Shigeo Nagashima, Putu Prathiwi Primadharsini, Satoshi Kunita, Reina Sasaki‐Tanaka, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, Ryuzo Abe, Keiichi Fujiwara, Osamu Yokosuka, Ryosuke Suzuki, Koji Ishii, Hiroshi Yotsuyanagi, Hiroaki Okamoto, The AMED HAV and HEV Study Group, Mai Totsuka, Masayuki Honda, Shuhei Arima, Ryota Masuzaki, Naoki Matsumoto, Masahiro Ogawa, Hayato Abe, Masato Nakamura, Shuang Wu, Naoya Kato, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Shuji Terai, Jong‐Hon Kang, Tominari Kobayashi, Norio Isoda, Shunji Watanabe, Hitoshi Mizuo, Junichi Koyama, Hitoshi Takagi, Yuichi Yamazaki, Yukihiro Sato, Hiroshi Okano, Tatsunori Nakano, Manri Kawakami, Akio Miyasaka, Tomohiko Koibuchi, Ryuichi Sugiyama, Mami Matsuda, Asuka Hirai‐Yuki   +48 more
wiley   +1 more source

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.

PLoS ONE, 2015
Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao, Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, To Sing Fung, Yan-Quan Wei, Shi-Chong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding Xiang Liu, Xiang-Tao Liu   +10 more
doaj   +1 more source

Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Abstract Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic reprogramming in A549 lung epithelial cells.
Blanca D. López‐Ayllón, Silvia Marin, Marco Fariñas Fernández, Tránsito García‐García, Raúl Fernández‐Rodríguez, Ana de Lucas‐Rius, Natalia Redondo, Laura Mendoza‐García, Carles Foguet, Juozas Grigas, Alba Calvet, José Manuel Villalba, María Josefa Rodríguez Gómez, Diego Megías, Biagio Mandracchia, Daniel Luque, Juan José Lozano, Cristina Calvo, Unai Merino Herrán, Timothy M. Thomson, Juan J. Garrido, Marta Cascante, María Montoya   +22 more
wiley   +1 more source

The effect of amantadine on an ion channel protein from Chikungunya virus.

PLoS Neglected Tropical Diseases, 2019
Viroporins like influenza A virus M2, hepatitis C virus p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, and create hydrophilic corridors, which are critical for viral entry, replication and egress.
Debajit Dey, Shumaila Iqbal Siddiqui, Prabhudutta Mamidi, Sukanya Ghosh, Chandra Shekhar Kumar, Soma Chattopadhyay, Subhendu Ghosh, Manidipa Banerjee   +7 more
doaj   +1 more source

Long COVID and post‐acute sequelae of SARS‐CoV‐2 pathogenesis and treatment: A Keystone Symposia report

Annals of the New York Academy of Sciences, Volume 1535, Issue 1, Page 31-41, May 2024.
Abstract In 2023, the Keystone Symposia held the first international scientific conference convening research leaders investigating the pathology of post‐acute sequelae of COVID‐19 (PASC) or Long COVID, a growing and urgent public health priority.
Matthew S. Durstenfeld, Shannon Weiman, Michael Holtzman, Catherine Blish, Resia Pretorius, Steven G. Deeks   +5 more
wiley   +1 more source

Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus [PDF]

, 2016
It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation.
Aguilella, Vicente, Ding, Xiang Liu, Li, Yan, Queralt-Martín, María, Surya, Wahyu, To, Janet, To, Sing Fung, Torres, Jaume, Verdiá Báguena, Carmen   +8 more
core   +2 more sources

Exploring the Anti-Influenza Activity of closo-Borate Platforms: Structure–Activity Relationship of Amino Acid-Functionalized closo-Dodecaborate Derivatives Against Influenza Virus A/Cheboksary/125/2020 (H1N1)pdm09

Molecules
The emergence of drug-resistant influenza virus strains necessitates the development of novel antiviral agents with unique mechanisms of action. This study presents the synthesis and in vitro evaluation of a new class of antiviral compounds: sodium salts
Timur M. Garaev, Ilya I. Yudin, Natalya V. Breslav, Tatyana V. Grebennikova, Evgenii Yu. Matveev, Elizaveta A. Eshtukova-Shcheglova, Ilya E. Sokolov, Varvara V. Avdeeva, Konstantin Yu. Zhizhin, Nikolai T. Kuznetsov   +9 more
doaj   +1 more source

The Human Metapneumovirus Small Hydrophobic Protein has Properties Consistent with Those of a Viroporin and Can Modulate Viral Fusogenic Activity [PDF]

, 2014
Human metapneumovirus (HMPV) encodes three glycoproteins: the glycoprotein, which plays a role in glycosaminoglycan binding, the fusion (F) protein, which is necessary and sufficient for both viral binding to the target cell and fusion between the ...
Chang, Andres, Dutch, Rebecca Ellis, Jones, Angela, Masante, Cyril, Moncman, Carole L., Najjar, Farah El   +5 more
core   +3 more sources

Characterization of subspecies B1 human adenovirus ORF E3-10.9K [PDF]

, 2010
Subspecies B1 human adenoviruses (HAdVs) are important causes of acute respiratory disease in pediatric and military recruit populations. Although extensive epidemiological data document the genetic diversity of these human pathogens, little is known ...
Frietze, Kathryn Marie
core   +1 more source