Results 101 to 110 of about 1,807 (187)

Definition of the cellular interactome of the highly pathogenic avian influenza H5N1 virus: identification of human cellular regulators of viral entry, assembly, and egress. [PDF]

, 2016
This study was supported by the Research Fund for the Control of Infectious Diseases, Food and Health Bureau, Hong Kong SAR Government (#09080892), University Grants Committee Area of Excellence Scheme (AoE/M-12/-06), French Ministry of Health, RESPARI ...
Bruzzone, R, Kien, F, Ma, HL, Nal, B, Poon, LLM   +4 more
core   +1 more source

The Role of the Early Secretory Pathway in Foot-and-Mouth Disease Virus Replication

, 2011
Foot-and-Mouth Disease Virus (FMDV) induces rearrangements of host-cell membranes to generate vesicles that are believed to provide platforms for formation of the viral replication complex. The cellular origin of these vesicles and the properties that
Midgley, Rebecca Julie, Midgley, Rebecca Julie   +1 more
core   +1 more source

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam, Vinod R. M. T. Balasubramaniam   +1 more
wiley   +1 more source

Impact of histidine residues on the transmembrane helices of viroporins [PDF]

Molecular Membrane Biology, 2013
Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan, Park, Sang Ho, Tian, Ye, Opella, Stanley J   +3 more
openaire   +4 more sources

MBEToolbox 2.0: An enhanced version of a MATLAB toolbox for Molecular Biology and Evolution [PDF]

, 2006
MBEToolbox is an extensible MATLAB-based software package for analysis of DNA and protein sequences. MBEToolbox version 2.0 includes enhanced functions for phylogenetic analyses by the maximum likelihood method.
James J. Cai, David K. Smith, Xuhua Xia, Kwok-yung Yuen   +3 more
core   +1 more source

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

The Feline calicivirus Leader of the Capsid (LC) Protein Contains a Putative Transmembrane Domain, Binds to the Cytoplasmic Membrane, and Exogenously Permeates Cells

Viruses
Feline calicivirus (FCV), an important model for studying the biology of the Caliciviridae family, encodes the leader of the capsid (LC) protein, a viral factor known to induce apoptosis when expressed in a virus-free system.
Yoatzin Peñaflor-Téllez, Jesús Alejandro Escobar-Almazan, Carolina Pérez-Ibáñez, Carlos Emilio Miguel-Rodríguez, Jaury Gómez de la Madrid, Erick I. Monge-Celestino, Patricia Talamás-Rohana, Ana Lorena Gutiérrez-Escolano   +7 more
doaj   +1 more source

Long‐term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged.
Laetitia Gay, Valérie Desquiret‐Dumas, Nicolas Nagot, Clara Rapenne, Philippe Van de Perre, Pascal Reynier, Jean‐Pierre Molès   +6 more
wiley   +1 more source

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome [PDF]

, 2015
Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death.
Aguilella, Vicente M, Castaño-Rodriguez, Carlos, Enjuanes, Luis, Fernandez-Delgado, Raul, Jimenez-Guardeño, Jose Manuel, Nieto-Torres, Jose Luis, Regla-Nava, Jose Angel, Torres, Jaume, Verdiá-Báguena, Carmina   +8 more
core   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source