The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholThe cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
europepmc +2 more sources
Targeting Host Calcium Channels and Viroporins: A Promising Strategy for SARS-CoV-2 Therapy [PDF]
Future Virology, 2023 Mona Fani +2 more
exaly +2 more sources
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease
Viruses, 2021 The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development of novel vaccines and much needed
Siobhan Gargan, Nigel J. Stevenson
doaj +1 more source
Reply to: How Many SARS-CoV-2 “Viroporins” Are Really Ion Channels? [PDF]
Communications Biology, 2022 Trine L. Toft-Bertelsen +6 more
doaj +2 more sources
The role of severe acute respiratory syndrome coronavirus 2 viroporins in inflammation
Advances in Human Biology, 2022 In December 2019, genomic screening of clinical samples from patients with viral pneumonia in Wuhan, China, revealed the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Arghavan Zebardast +2 more
doaj +1 more source
Viroporin-mediated calcium-activated autophagy [PDF]
Autophagy, 2013 Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
openaire +2 more sources
In Situ Spectroscopic Detection of Large-Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening [PDF]
, 2023 Viroporins are small ion channels in membranes of enveloped viruses that play key roles during viral life cycles. To use viroporins as drug targets against viral infection requires in-depth mechanistic understanding and, with that, methods that enable ...
Kozuch, Jacek +4 more
core +4 more sources
Membrane Integration of Poliovirus 2B Viroporin [PDF]
Journal of Virology, 2011 ABSTRACT Virus infections can result in a variety of cellular injuries, and these often involve the permeabilization of host membranes by viral proteins of the viroporin family. Prototypical viroporin 2B is responsible for the alterations in host cell membrane permeability that take place in enterovirus-infected cells. 2B protein
Martínez Gil, Luis +6 more
openaire +5 more sources
Addressing SARS-CoV-2 viroporins with antiarrhythmic drugs. [PDF]
EuropaceBloothooft M, Voigt N, de Boer TP.
europepmc +5 more sources
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger +3 more
doaj +1 more source