Results 31 to 40 of about 1,355 (133)
Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped single-stranded positive-sense RNA virus, is a member of the genus Betacoronavirus, family Coronaviridae.
Ulrike Breitinger +3 more
doaj +1 more source
SARS-CoV-2 E and 3a Proteins Are Inducers of Pannexin Currents
Cells, 2023 Controversial reports have suggested that SARS-CoV E and 3a proteins are plasma membrane viroporins. Here, we aimed at better characterizing the cellular responses induced by these proteins. First, we show that expression of SARS-CoV-2 E or 3a protein in
Barbara B. R. Oliveira-Mendes +10 more
doaj +1 more source
Retrovirology, 2022 Background Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for viroporins.
Wyatt Henke +4 more
doaj +1 more source
The antiviral targeting potential of viroporins
, 2022 Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine ...
Weis, Nina +9 more
core +1 more source
Viruses, 2010 The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus ...
Eike Steinmann, Thomas Pietschmann
doaj +1 more source
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
Viruses, 2014 To get access to the replication site, small non-enveloped DNA viruses have to cross the cell membrane using a limited number of capsid proteins, which also protect the viral genome in the extracellular environment.
Eva Bilkova +2 more
doaj +1 more source
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies
Viruses, 2021 Evidence is emerging that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect various organs of the body, including cardiomyocytes and cardiac endothelial cells in the heart.
Huyen Tran Ho +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella +10 more
wiley +1 more source
SARS-CoV-2 Viroporins: A Multi-Omics Insight from Nucleotides to Amino Acids
, 2022 COVID-19 is caused by SARS-CoV-2 which has so far affected more than 500 million people worldwide and killed over 6 million as of 1 May 2022. The approved emergency-use vaccines were lifesaving in such a devastating pandemic.
Soham Saha +3 more
core +1 more source