Results 31 to 40 of about 1,466 (157)

Computational Electrophysiology simulation study of the Dengue virus Viroporins

Journal of Biomolecular Structure and Dynamics
<p>This is the dataset of input files, parameter files and run files for the various protein conformations generated in the study "Computational Electrophysiology simulation study of the Dengue virus Viroporins".</p ...
Chaudhuri, Dwaipayan, Giri, Kalyan, Majumder, Satyabrata   +2 more
core   +3 more sources

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy [PDF]

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +2 more sources

The human polyoma JC virus agnoprotein acts as a viroporin.

PLoS Pathogens, 2010
Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Tadaki Suzuki, Yasuko Orba, Yuki Okada, Yuji Sunden, Takashi Kimura, Shinya Tanaka, Kazuo Nagashima, William W Hall, Hirofumi Sawa   +8 more
doaj   +4 more sources

Viroporins : discovery, methods of study, and mechanisms of host-membrane permeabilization

Quarterly Reviews of Biophysics
The ‘Viroporin’ family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence and structural diversity, viroporins share a common functional trend: their capacity to assemble ...
Nieva, Jose L, Nieva, José Luis, Alcaraz, Antonio   +2 more
core   +4 more sources

The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]

Mol Plant Pathol
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y, Fan X, Luan Y, Li Y, Zhao Y, Ji W, Li N, Wu X, Cheng X, Bai Y.   +9 more
europepmc   +2 more sources

Correction for Castaño-Rodriguez et al., “Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis” [PDF]

mBio, 2023
Carlos Castaño-Rodríguez, Jose M. Honrubia, Javier Gutierrez-Álvarez, Marta L. DeDiego, Jose L. Nieto-Torres, Jose M. Jimenez-Guardeño, Jose A. Regla-Nava, Raul Fernandez-Delgado, Carmina Verdia-Báguena, Maria Queralt-Martín, Grazyna Kochan, Stanley Perlman, Vicente M. Aguilella, Isabel Sola, Luis Enjuanes   +14 more
doaj   +2 more sources

Analysis of Viroporins and Membrane Systems With Native Mass Spectrometry

, 2023
Viroporins are a class of viral membrane proteins that play diverse roles in the viral infection cycle. Viroporins are known to play roles in ion transport, inducing membrane curvature, as well as participating in a variety of protein-protein ...
Townsend, Julia
core   +4 more sources

Structural Bases for the Unconventional Activity of a Viroporin Channel. [PDF]

Biochemistry
Viroporins alter the permeability of cell membranes and regulate the initiation/progression of the viral infection cycle. However, the "unconventional" membrane channel behavior displayed by many members of the family challenges their general validation as therapeutic targets.
Wiley B, Largo E, Nabais L, Nieva JL, Domene C.   +4 more
europepmc   +3 more sources

A hidden gene in astroviruses encodes a viroporin [PDF]

Nature Communications, 2020
Abstract Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children worldwide and have been associated with encephalitis and meningitis in immunocompromised individuals.
Lulla, Valeria, Firth, Andrew E.
openaire   +4 more sources

Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]

Microbial Physiology, 2022
Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler, Kevin J. Hendargo, Arturo Medrano-Soto, Milton H. Saier   +3 more
openaire   +2 more sources