Results 31 to 40 of about 1,345 (158)

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? [PDF]

Viruses, 2015
Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle, Samuel John Dobson, Marietta Müller, Andrew Macdonald   +3 more
doaj   +2 more sources

SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore [PDF]

Frontiers in Immunology, 2023
BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri, Alessia Angelin, Deborah G. Murdock, Patrick Schaefer, Prasanth Portluri, Timothy Lie, Timothy Lie, Jessica Huang, Douglas C. Wallace, Douglas C. Wallace   +9 more
doaj   +2 more sources

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +3 more sources

The human polyoma JC virus agnoprotein acts as a viroporin.

PLoS Pathogens, 2010
Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Tadaki Suzuki, Yasuko Orba, Yuki Okada, Yuji Sunden, Takashi Kimura, Shinya Tanaka, Kazuo Nagashima, William W Hall, Hirofumi Sawa   +8 more
doaj   +4 more sources

Computational Electrophysiology simulation study of the Dengue virus Viroporins

Journal of Biomolecular Structure and Dynamics
<p>This is the dataset of input files, parameter files and run files for the various protein conformations generated in the study "Computational Electrophysiology simulation study of the Dengue virus Viroporins".</p ...
Chaudhuri, Dwaipayan, Giri, Kalyan, Majumder, Satyabrata   +2 more
core   +3 more sources

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]

mBio, 2010
Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser, Matthew R. Collinson-Pautz, Budi Utama, Mary K. Estes   +3 more
doaj   +3 more sources

The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]

Mol Plant Pathol
The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y, Fan X, Luan Y, Li Y, Zhao Y, Ji W, Li N, Wu X, Cheng X, Bai Y.   +9 more
europepmc   +2 more sources

Viroporins : discovery, methods of study, and mechanisms of host-membrane permeabilization

Quarterly Reviews of Biophysics
The ‘Viroporin’ family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence and structural diversity, viroporins share a common functional trend: their capacity to assemble ...
Nieva, Jose L, Nieva, José Luis, Alcaraz, Antonio   +2 more
core   +4 more sources

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Drug Design, Development and Therapy, 2018
Yasmine M Mandour,1 Ulrike Breitinger,2 Chunlong Ma,3 Jun Wang,3 Frank M Boeckler,4 Hans-Georg Breitinger,2 Darius P Zlotos1 1Department of Pharmaceutical Chemistry, German University in Cairo, 2Department of Biochemistry, The German University in Cairo,
Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP   +6 more
doaj   +1 more source

A hidden gene in astroviruses encodes a viroporin [PDF]

Nature Communications, 2020
Abstract Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children worldwide and have been associated with encephalitis and meningitis in immunocompromised individuals.
Lulla, Valeria, Firth, Andrew E.
openaire   +4 more sources