Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [PDF]
Chemistry of Heterocyclic Compounds, 2020 [Figure not available: see fulltext.] Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new ...
Shiryaev Vadim A.
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Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease
Viruses, 2021 The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development of novel vaccines and much needed
Siobhan Gargan, Nigel J. Stevenson
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Viroporins: Structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed ‘viroporins’ is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these ...
Griffin, S, Scott, C
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Viruses, 2015 Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung +2 more
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Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis [PDF]
Viruses, 2015 Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming
Jose L. Nieto-Torres +4 more
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The antiviral targeting potential of viroporins
Ugeskrift for laeger, 2022 Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine ...
Weis, Nina +9 more
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Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? [PDF]
Viruses, 2015 Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle +3 more
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Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies [PDF]
Microbial PhysiologyIntroduction: Viroporins are small multifunctional proteins that modify cellular membranes facilitating processes such as viral nucleic acid entry and the release of virions from infected cells.
Jianing Wang +6 more
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A BSL-2 chimeric system designed to screen SARS-CoV-2 E protein ion channel inhibitors [PDF]
Journal of VirologyA major hindrance to the identification of new drug targets and the large-scale testing of new or existing compound libraries against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is that research on the virus is restricted to biosafety ...
Vashi Negi, Richard J. Kuhn
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SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells [PDF]
Cell Death DiscoveryInflammasome assembly is a potent mechanism responsible for the host protection against pathogens, including viruses. When compromised, it can allow viral replication, while when disrupted, it can perpetuate pathological responses by IL-1 signaling and ...
Magdalena Ambrożek-Latecka +13 more
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