Results 21 to 30 of about 1,355 (133)
The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
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Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? [PDF]
Viruses, 2015 Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle +3 more
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A BSL-2 chimeric system designed to screen SARS-CoV-2 E protein ion channel inhibitors [PDF]
Journal of VirologyA major hindrance to the identification of new drug targets and the large-scale testing of new or existing compound libraries against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is that research on the virus is restricted to biosafety ...
Vashi Negi, Richard J. Kuhn
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Searching for Blockers of Dengue and West Nile Virus Viroporins
Viruses, 2022 Flavivirus infections, such as those caused by dengue and West Nile viruses, emerge as new challenges for the global healthcare sector. It has been found that these two viruses encode ion channels collectively termed viroporins. Therefore, drug molecules
Hiya Lahiri, Isaiah T. Arkin
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The Small Cysteine-Rich Protein of Potato Mop-Top Virus Exhibits Viroporin Activity. [PDF]
Mol Plant PatholThe cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Liu Y +9 more
europepmc +2 more sources
Analysis of Viroporins and Membrane Systems With Native Mass Spectrometry
, 2023 Viroporins are a class of viral membrane proteins that play diverse roles in the viral infection cycle. Viroporins are known to play roles in ion transport, inducing membrane curvature, as well as participating in a variety of protein-protein ...
Townsend, Julia
core +4 more sources
Drug Design, Development and Therapy, 2018 Yasmine M Mandour,1 Ulrike Breitinger,2 Chunlong Ma,3 Jun Wang,3 Frank M Boeckler,4 Hans-Georg Breitinger,2 Darius P Zlotos1 1Department of Pharmaceutical Chemistry, German University in Cairo, 2Department of Biochemistry, The German University in Cairo,
Mandour YM +6 more
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The role of severe acute respiratory syndrome coronavirus 2 viroporins in inflammation
Advances in Human Biology, 2022 In December 2019, genomic screening of clinical samples from patients with viral pneumonia in Wuhan, China, revealed the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Arghavan Zebardast +2 more
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Viroporins of Mpox Virus. [PDF]
Int J Mol Sci, 2023 Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore,
Basu K, Krugliak M, Arkin IT.
europepmc +2 more sources
How many SARS-CoV-2 “viroporins” are really ion channels? [PDF]
Communications Biology, 2022 The SARS-CoV-2 virus uses a small number of viral proteins to enter host cells and disrupt their activity, including the spike (S), membrane (M), and envelope (E) proteins, as well as a number of accessory proteins of unknown function (Orf3a, Orf8, Orf10,
Neil L. Harrison +12 more
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