Results 21 to 30 of about 1,807 (187)
The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
doaj +2 more sources
Searching for Blockers of Dengue and West Nile Virus Viroporins [PDF]
Viruses, 2022 Flavivirus infections, such as those caused by dengue and West Nile viruses, emerge as new challenges for the global healthcare sector. It has been found that these two viruses encode ion channels collectively termed viroporins. Therefore, drug molecules
Hiya Lahiri, Isaiah T. Arkin
doaj +2 more sources
SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore [PDF]
Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
doaj +2 more sources
Pharmacological ResearchA class of proteins encoded by viral genomes, referred to as viroporins, is composed of small hydrophobic proteins that form pores or ion channels in host membranes. These proteins modulate the viral life cycle and pathogenicity.
bingqing xia
exaly +3 more sources
Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
Viruses, 2015 Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle +2 more
exaly +3 more sources
Viroporins of Mpox Virus. [PDF]
Int J Mol Sci, 2023 Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Basu K, Krugliak M, Arkin IT.
europepmc +3 more sources
Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays [PDF]
Viruses, 2019 Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar +3 more
doaj +3 more sources
The human polyoma JC virus agnoprotein acts as a viroporin.
PLoS Pathogens, 2010 Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability.
Tadaki Suzuki +8 more
doaj +4 more sources
Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity [PDF]
mBio, 2010 Many viruses alter intracellular calcium homeostasis. The rotavirus nonstructural protein 4 (NSP4), an endoplasmic reticulum (ER) transmembrane glycoprotein, increases intracellular levels of cytoplasmic Ca2+ ([Ca2+]cyto) through a phospholipase C ...
Joseph M. Hyser +3 more
doaj +3 more sources
Viroporins: A new target for fighting viral infections [PDF]
, 2017 Over the last years an increasing number of viruses have jumped into the mass media and several names or acronyms (Ebola, zika, SARS, MERS,…) have become familiar to the general public because of the high mortality rates associated with their infection ...
Aguilella, Vicente
core +2 more sources