Results 21 to 30 of about 1,345 (158)
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [PDF]
Chemistry of Heterocyclic Compounds, 2020 [Figure not available: see fulltext.] Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new ...
Shiryaev Vadim A.
core +3 more sources
Viroporins: Structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed ‘viroporins’ is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these ...
Griffin, S, Scott, C
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Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease
Viruses, 2021 The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development of novel vaccines and much needed
Siobhan Gargan, Nigel J. Stevenson
doaj +2 more sources
Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis [PDF]
Viruses, 2015 Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming
Jose L. Nieto-Torres +4 more
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SARS-CoV-2 E and 3a Proteins Are Inducers of Pannexin Currents
Cells, 2023 Controversial reports have suggested that SARS-CoV E and 3a proteins are plasma membrane viroporins. Here, we aimed at better characterizing the cellular responses induced by these proteins. First, we show that expression of SARS-CoV-2 E or 3a protein in
Barbara B. R. Oliveira-Mendes +10 more
doaj +2 more sources
A BSL-2 chimeric system designed to screen SARS-CoV-2 E protein ion channel inhibitors [PDF]
Journal of VirologyA major hindrance to the identification of new drug targets and the large-scale testing of new or existing compound libraries against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is that research on the virus is restricted to biosafety ...
Vashi Negi, Richard J. Kuhn
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Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39 [PDF]
British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier +4 more
wiley +2 more sources
, 2015 Virus encoded ion channels, termed viroporins, are expressed by a diverse set of viruses and have been found to target nearly every host cell membrane and compartment, including endocytic/exocytic vesicles, ER, mitochondria, Golgi, and the plasma membrane. Viroporins are generally very small (
Joseph M. Hyser
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The antiviral targeting potential of viroporins
Ugeskrift for laeger, 2022 Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine ...
Weis, Nina +9 more
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The 6-kilodalton peptide 1 of the family Potyviridae: small in size but powerful in function [PDF]
Frontiers in MicrobiologyThe Potyviridae family is one of the most economically significant groups of plant RNA viruses, causing severe yield losses in agriculturally important crops.
Liansheng Yu +7 more
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