Results 41 to 50 of about 3,182 (158)
Viruses, 2019 Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with ...
Zengbin Li +4 more
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eLife, 2020 Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw +21 more
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The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion
mBio, 2023 The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus’ cell tropism and its evasion of host innate immune responses.
Anna Luganini +6 more
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Viroporins: structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these proteins for antiviral development.
Scott, C, Griffin, S
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Unveiling the viroporin arsenal in plant viruses: Implications for the future. [PDF]
PLoS PathogViroporins are small, hydrophobic viral proteins that modify cellular membranes to form tiny pores for influx of ions and small molecules. Previously, viroporins were identified exclusively in vertebrate viruses. Recent studies have shown that both plant-infecting positive-sense single-stranded (+ss) and negative-sense single-stranded (-ss) RNA viruses
Wu G, Chen J, Wang A, Yan F.
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Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif
Viruses, 2015 Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
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Viruses, 2022 The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel.
Isobel Webb +8 more
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Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]
FEBS Letters, 2003 Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L. +3 more
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Viral Membrane Channels: Role and Function in the Virus Life Cycle
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
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The minimalist architectures of viroporins and their therapeutic implications
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity.
OuYang, Bo, Chou, James J.
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