Results 41 to 50 of about 3,761 (176)
Discovery and Characterization of the Phospholemman/SIMP/Viroporin (PSV) Superfamily [PDF]
, 2021 Determining the relatedness between biological entities can translate to knowledge which would otherwise be difficult to uncover without greater context.
Tyler, Daniel
core +1 more source
Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins. [PDF]
VirusesViruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins. Several studies have characterized the role of 6K in alphavirus budding and infection since its discovery in the late 1970s.
Negi V, Miller AS, Kuhn RJ.
europepmc +4 more sources
Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-like Superfamilies [PDF]
, 2023 Viroporins are small multifunctional proteins that modify cellular membranes to facilitate viral infections such as viral nucleic acid entry and the release of virions from infected cells.
Wang, Jianing
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Identification of BK Polyomavirus Agnoprotein as a Novel Viroporin [PDF]
, 2019 BK polyomavirus (BKPyV) is a small dsDNA virus and a common opportunistic infection in kidney transplant patients where it causes polyomavirus associated nephropathy (PVAN).
Swinscoe, Gemma Ede
core +5 more sources
Pathophysiological Consequences of Calcium-Conducting Viroporins [PDF]
Annual Review of Virology, 2015 Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain and regulate transmembrane ion gradients. As intracellular parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt normal ionic homeostasis to promote viral replication and pathogenesis.
Joseph M, Hyser, Mary K, Estes
openaire +2 more sources
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [PDF]
Chemistry of Heterocyclic Compounds, 2020 Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new inhibitors. In this review, we analyze the data published over the last 10 years on known ion channels of viruses that cause socially ...
Shiryaev, Vadim A., Klimochkin, Yuri N.
openaire +2 more sources
The citrus tristeza virus p33 protein functions as a viroporin. [PDF]
PLoS PathogViroporins are viral proteins that form ion channels in the membranes of the host and, thus, alter the host ion homeostasis to create more favorable environments for the virus. Since the discovery of the ion channel activity of the M2 protein encoded by influenza virus A (species: Alphainfluenzavirus influenzae
Aknadibossian V +5 more
europepmc +4 more sources
, 2022 Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is
Tyler D. (12076325) +3 more
core +1 more source
Viroporin-mediated calcium-activated autophagy [PDF]
Autophagy, 2013 Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
openaire +2 more sources
Viruses, 2021 ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan +5 more
doaj +1 more source