Results 41 to 50 of about 4,749 (194)

The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.

PLoS ONE, 2011
Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain.
Björn D Kuhl, Vicky Cheng, Daniel A Donahue, Richard D Sloan, Chen Liang, John Wilkinson, Mark A Wainberg   +6 more
doaj   +1 more source

Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein

Viruses, 2021
ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan, Elizabeth Patton, Carol A. Munro, Dora E. Corzo-Leon, Andrew J. Porter, Soumya Palliyil   +5 more
doaj   +1 more source

In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin

mSphere, 2020
Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in a series of additional articles that ...
Robert Daniels, Daniel N. Hebert
doaj   +1 more source

Inhibition of SARS-CoV-2 Viral Channel Activity Using FDA-Approved Channel Modulators Independent of Variants

Biomolecules, 2022
Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu, Gina Sizemore, Ivan Martinez, Peter Perrotta   +3 more
doaj   +1 more source

Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]

Microbial Physiology, 2022
Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler, Kevin J. Hendargo, Arturo Medrano-Soto, Milton H. Saier   +3 more
openaire   +2 more sources

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

Viruses, 2019
Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with ...
Zengbin Li, Zixiao Zou, Zeju Jiang, Xiaotian Huang, Qiong Liu   +4 more
doaj   +1 more source

Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B [PDF]

, 2018
Nonstructural protein 2B of foot-and-mouth disease (FMD) virus (FMDV) is comprised of a small, hydrophobic, 154-amino-acid protein. Structure-function analyses demonstrated that FMDV 2B is an ion channel-forming protein.
Aguilella, Vicente, Alcaraz, Antonio, Arrondo, Jose Luis, Berggren, Keith, Borca, Manuel V., Brocchi, Emiliana, Carrillo, C., de la Arada, Igor, Gladue, Douglas, Holinka, L.G., Largo, Eneko, Nieva, Jose L, Ramirez-Medina, Elizabeth, Vuono, Elizabeth   +13 more
core   +1 more source

Ebola Virus Delta Peptide Is a Viroporin [PDF]

Journal of Virology, 2017
ABSTRACT The Ebola virus (EBOV) genome encodes a partly conserved 40-residue nonstructural polypeptide, called the delta peptide, that is produced in abundance during Ebola virus disease (EVD). The function of the delta peptide is unknown, but sequence analysis has suggested that delta peptide could be a viroporin, belonging to a diverse ...
Jing, He, Lilia I, Melnik, Alexander, Komin, Gregory, Wiedman, Taylor, Fuselier, Cameron F, Morris, Charles G, Starr, Peter C, Searson, William R, Gallaher, Kalina, Hristova, Robert F, Garry, William C, Wimley   +11 more
openaire   +2 more sources

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +1 more source

The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion

mBio, 2023
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus’ cell tropism and its evasion of host innate immune responses.
Anna Luganini, Valentina Serra, Giorgia Scarpellino, Shree Madhu Bhat, Luca Munaron, Alessandra Fiorio Pla, Giorgio Gribaudo   +6 more
doaj   +1 more source