Results 41 to 50 of about 4,200 (198)

Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization

Frontiers in Microbiology, 2022
The exact function(s) of the lagovirus non-structural protein p23 is unknown as robust cell culture systems for the Rabbit haemorrhagic disease virus (RHDV) and other lagoviruses have not been established.
Michael Frese, Robyn Hall, Matthew Neave   +2 more
exaly   +3 more sources

Identification and Structural Characterization of Viroporins from Deadly Hemorrhagic Viruses [PDF]

Viruses
Crimean–Congo hemorrhagic fever virus (CCHF-V) and Ebola virus are lethal pathogens that cause widespread outbreaks of hemorrhagic fever. Both diseases can be transmitted through contact with the bodily fluids of infected individuals, but as an arbovirus,
Hiya Lahiri, Kingshuk Basu, Isaiah T. Arkin   +2 more
doaj   +2 more sources

Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

eLife
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes ...
Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin   +16 more
doaj   +2 more sources

Functional redundancy in Oxa1-family insertases supports robust membrane insertion of influenza A virus M2 viroporin

bioRxiv
The biogenesis of thousands of highly diverse membrane proteins in humans is facilitated by an array of ER-resident membrane protein translocases.
Diwo C, Alenquer M, Zhou S, Digard P, Adrain C, Amorim MJ.   +5 more
europepmc   +2 more sources

The leader of the capsid protein from Feline calicivirus must be palmitoylated and form oligomers through disulfide bonds for efficient viral replication [PDF]

Journal of Virology
Feline calicivirus (FCV), a member of the genus Vesivirus and a model for studying members of the family Caliciviridae, has been used to understand the biology and viral replication of etiological agents of medical and veterinary importance.
Yoatzin Peñaflor-Téllez, Jaury Gómez de la Madrid, Erick Ignacio Monge-Celestino, Carolina Pérez-Ibáñez, Randy Seir Llanas Vázquez, Sharon Itzel Sosa Mondragon, Carlos Emilio Miguel-Rodríguez, Ana Lorena Gutiérrez-Escolano   +7 more
doaj   +2 more sources

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.

PLoS ONE, 2015
Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao, Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, To Sing Fung, Yan-Quan Wei, Shi-Chong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding Xiang Liu, Xiang-Tao Liu   +10 more
doaj   +2 more sources

Exploring the structural and functional dynamics of trimeric and tetrameric states of influenza encoded PB1-F2 viroporin through molecular dynamics simulations.

Journal of Molecular Graphics and Modelling
Influenza Viruses have always been a major health concern due to their highly contagious nature. The PB1-F2 viroporin encoded by the influenza A virus is known to be a pro-apoptotic protein involved in cell death induction of the host immune cells.
Sehrish Jamal, S. T. Moin, S. Haider
semanticscholar   +2 more sources

Monoclonal antibody 1B9 against the African swine fever virus viroporin pB169L: molecular characterization and epitope mapping

Frontiers in Microbiology
IntroductionThe African swine fever virus (ASFV) viroporin pB169L is a conserved membrane protein, but well-defined reagents for its detection and molecular characterization remain limited.MethodsA soluble recombinant antigen comprising the non ...
Zhiying Cui, Zhiying Cui, Jianing Feng, Jianing Feng, Miaomiao Ye, Miaomiao Ye, Qin Wen, Qin Wen, Peng Gao, Peng Gao, Qiongqiong Zhou, Qiongqiong Zhou, Yongning Zhang, Yongning Zhang, Lei Zhou, Lei Zhou, Xinna Ge, Xinna Ge, Xin Guo, Xin Guo, Jun Han, Jun Han, Hanchun Yang, Hanchun Yang   +23 more
doaj   +2 more sources

Identification of BK Polyomavirus Agnoprotein as a Novel Viroporin [PDF]

, 2019
BK polyomavirus (BKPyV) is a small dsDNA virus and a common opportunistic infection in kidney transplant patients where it causes polyomavirus associated nephropathy (PVAN).
Swinscoe, Gemma Ede
core   +5 more sources

Viroporins of Mpox Virus

International Journal of Molecular Sciences, 2023
Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged recently as a global threat. With a limited number of anti-viral drugs available for this new virus species, it is challenging to thwart the illness it begets. Therefore, characterizing new drug targets in the virus may prove advantageous to curbing the disease.
Kingshuk Basu, Miriam Krugliak, Isaiah T. Arkin   +2 more
openaire   +2 more sources