Results 51 to 60 of about 4,200 (198)
FEBS Letters, 2003 Viroporins are a group of proteins that participate in several viral functions, including the promotion of release of viral particles from cells. These proteins also affect cellular functions, including the cell vesicle system, glycoprotein trafficking and membrane permeability.
Gonzalez Portal, Maria Eugenia +1 more
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Coronavirus viroporins: structure and function [PDF]
The Ukrainian Biochemical Journal, 2021 Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction.
I. Zaloilo +3 more
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Viroporins in the Influenza Virus [PDF]
Cells, 2019 Influenza is a highly contagious virus that causes seasonal epidemics and unpredictable pandemics. Four influenza virus types have been identified to date: A, B, C and D, with only A–C known to infect humans. Influenza A and B viruses are responsible for seasonal influenza epidemics in humans and are responsible for up to a billion flu infections ...
Janet To, Jaume Torres
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Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily [PDF]
Microbial Physiology, 2022 Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is based on the transitivity property of homology complemented with five validation criteria: (1 ...
Daniel Tyler +3 more
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Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
doaj +1 more source
Viroporins: structure and biological functions [PDF]
Nature Reviews Microbiology, 2012 Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to their involvement in several diverse
Nieva, José Luis +2 more
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Discovery and Characterization of the Phospholemman/SIMP/Viroporin (PSV) Superfamily [PDF]
, 2021 Determining the relatedness between biological entities can translate to knowledge which would otherwise be difficult to uncover without greater context.
Tyler, Daniel
core +1 more source
Viroporin-mediated calcium-activated autophagy [PDF]
Autophagy, 2013 Autophagy is a cellular response activated by many pathogens, but the mechanism of activation is largely unknown. Recently we showed for the first time that rotavirus initiates the autophagy pathway through a calcium-mediated mechanism. Expression of the rotavirus-encoded NSP4, a pore-forming protein (viroporin), elicits the release of endoplasmic ...
Sue E, Crawford, Mary K, Estes
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Pathophysiological Consequences of Calcium-Conducting Viroporins [PDF]
Annual Review of Virology, 2015 Eukaryotic cells have evolved a myriad of ion channels, transporters, and pumps to maintain and regulate transmembrane ion gradients. As intracellular parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt normal ionic homeostasis to promote viral replication and pathogenesis.
Joseph M, Hyser, Mary K, Estes
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Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [PDF]
Chemistry of Heterocyclic Compounds, 2020 Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new inhibitors. In this review, we analyze the data published over the last 10 years on known ion channels of viruses that cause socially ...
Shiryaev, Vadim A., Klimochkin, Yuri N.
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