Results 51 to 60 of about 3,182 (158)

Impact of histidine residues on the transmembrane helices of viroporins [PDF]

Molecular Membrane Biology, 2013
Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan, Park, Sang Ho, Tian, Ye, Opella, Stanley J   +3 more
openaire   +4 more sources

Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?

Physiological Reports, 2021
Discovering therapeutics for COVID‐19 is a priority. Besides high‐throughput screening of compounds, candidates might be identified based on their known mechanisms of action and current understanding of the SARs‐CoV‐2 life cycle.
Kirk P. Conrad
doaj   +1 more source

Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]

Viruses, 2015
Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Nieva, Luis Carrasco
openaire   +5 more sources

Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus

Molecules, 2020
The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an ...
Maggie C. Duncan, Pascal Amoa Onguéné, Ibuki Kihara, Derrick N. Nebangwa, Maya E. Naidu, David E. Williams, Aruna D. Balgi, Kerstin Andrae-Marobela, Michel Roberge, Raymond J. Andersen, Masahiro Niikura, Fidele Ntie-Kang, Ian Tietjen   +12 more
doaj   +1 more source

Calicivirus Non-structural Proteins: Potential Functions in Replication and Host Cell Manipulation

Frontiers in Microbiology, 2021
The Caliciviridae are a family of viruses with a single-stranded, non-segmented RNA genome of positive polarity. The ongoing discovery of caliciviruses has increased the number of genera in this family to 11 (Norovirus, Nebovirus, Sapovirus, Lagovirus ...
Elena Smertina, Elena Smertina, Robyn N. Hall, Robyn N. Hall, Nadya Urakova, Tanja Strive, Tanja Strive, Michael Frese, Michael Frese   +8 more
doaj   +1 more source

Targeting the Channel Activity of Viroporins

, 2016
Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the ...
To, Janet, Surya, Wahyu, Torres, Jaume
openaire   +2 more sources

Potential Viroporin Candidates From Pathogenic Viruses Using Bacteria-Based Bioassays

Viruses, 2019
Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that are capable of ion transport. Building upon the ability to inhibit influenza by blocking its archetypical M2 H+ channel, as a family, viroporins may represent a ...
Prabhat Pratap Singh Tomar, Rivka Oren, Miriam Krugliak, Isaiah T. Arkin   +3 more
doaj   +1 more source

Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization

Frontiers in Microbiology, 2022
The exact function(s) of the lagovirus non-structural protein p23 is unknown as robust cell culture systems for the Rabbit haemorrhagic disease virus (RHDV) and other lagoviruses have not been established.
Elena Smertina, Elena Smertina, Elena Smertina, Adam J. Carroll, Joseph Boileau, Edward Emmott, Maria Jenckel, Harpreet Vohra, Vivien Rolland, Philip Hands, Junna Hayashi, Matthew J. Neave, Jian-Wei Liu, Robyn N. Hall, Robyn N. Hall, Tanja Strive, Tanja Strive, Michael Frese, Michael Frese   +18 more
doaj   +1 more source

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

Frontiers in Microbiology, 2020
Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. The recently characterized E protein ion channel activity (EIC) has also been implicated in modulating viral pathogenesis.
Shumin Li, Lixia Yuan, Guo Dai, Rui Ai Chen, Rui Ai Chen, Ding Xiang Liu, To Sing Fung   +6 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source