Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses [PDF]
, 2018 Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain of the Classical Swine Fever ...
Aguilella, Vicente +6 more
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Viroporins: structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these proteins for antiviral development.
Scott, C, Griffin, S
openaire +3 more sources
Membrane binding proteins of coronaviruses [PDF]
, 2019 Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of severities. Their members include zoonotic viruses with pandemic potential where therapeutic options are currently limited.
Entedar A J Alsaadi +3 more
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Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif
Viruses, 2015 Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
doaj +1 more source
Viruses, 2022 The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel.
Isobel Webb +8 more
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Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein [PDF]
, 2007 Background Mechanisms by which HIV-1 mediates reductions in CD4+ cell levels in infected persons are being intensely investigated, and have broad implications for AIDS drug and vaccine development.
Joshua M Costin +3 more
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Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]
Viruses, 2015 Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Nieva, Luis Carrasco
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Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]
, 2017 Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis +9 more
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Agnoprotein of polyomavirus BK interacts with proliferating cell nuclear antigen and inhibits DNA replication [PDF]
, 2015 License:Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein.
Barbara van Loon +9 more
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Physiological Reports, 2021 Discovering therapeutics for COVID‐19 is a priority. Besides high‐throughput screening of compounds, candidates might be identified based on their known mechanisms of action and current understanding of the SARs‐CoV‐2 life cycle.
Kirk P. Conrad
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