Results 51 to 60 of about 3,761 (176)
Viroporins: structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these proteins for antiviral development.
Scott, C, Griffin, S
openaire +3 more sources
Viruses, 2019 Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with ...
Zengbin Li +4 more
doaj +1 more source
Biomolecules, 2022 Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu +3 more
doaj +1 more source
The US21 viroporin of human cytomegalovirus stimulates cell migration and adhesion
mBio, 2023 The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus’ cell tropism and its evasion of host innate immune responses.
Anna Luganini +6 more
doaj +1 more source
Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif
Viruses, 2015 Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
doaj +1 more source
Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3 [PDF]
, 2013 Viroporins, which are encoded by a wide range of animal viruses, oligomerize in host cell membranes and form hydrophilic pores that can disrupt a number of physiological properties of the cell.
Suzuki, Tadaki +7 more
core +1 more source
Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]
FEBS Letters, 2003 Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L. +3 more
openaire +2 more sources
Viral Membrane Channels: Role and Function in the Virus Life Cycle
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
doaj +1 more source
The minimalist architectures of viroporins and their therapeutic implications
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity.
OuYang, Bo, Chou, James J.
openaire +2 more sources
Impact of histidine residues on the transmembrane helices of viroporins [PDF]
Molecular Membrane Biology, 2013 Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan +3 more
openaire +4 more sources