Results 1 to 10 of about 6,344 (144)

SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]

Communications Biology
ORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno   +9 more
doaj   +3 more sources

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis [PDF]

Viruses
The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated ...
Edward B. Stephens, Dusan Kunec, Wyatt Henke, Ricardo Martin Vidal, Brandon Greishaber, Rabina Saud, Maria Kalamvoki, Gagandeep Singh, Sujan Kafle, Jessie D. Trujillo, Franco Matias Ferreyra, Igor Morozov, Juergen A. Richt   +12 more
doaj   +3 more sources

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis [PDF]

Frontiers in Immunology
Subgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied.
Yifan Zhang, Jing Li, Xinglong Zhang, Xin Zhang, Jiali Li, Heng Li, Heng Li, Heng Li, Xin Zhao, Xin Zhao, Xin Zhao, Zihan Zhang, Yingyan Li, Keqi Chen, Shasha Peng, Haijing Shi, Haijing Shi, Haijing Shi, Longding Liu, Longding Liu, Longding Liu   +20 more
doaj   +3 more sources

Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19

Frontiers in Microbiology, 2022
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-19-related morbidity and mortality, and the high mutability of the virus.
Jiantao Zhang, Volodymyr Gerzanich, Mohamed Nasr   +2 more
exaly   +4 more sources

Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the AND-System cognitive platform, graph neural networks, and molecular [PDF]

Вавиловский журнал генетики и селекции
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions.
T. V. Ivanisenko, P. S. Demenkov, M. A. Kleshchev, V. A. Ivanisenko   +3 more
doaj   +3 more sources

COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels [PDF]

mBio
The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected individuals with pre-existing medical conditions, such as neurocognitive disorders.
Volodymyr Gerzanich, Chenyu Zhang, Jiantao Zhang, Bhargava Teja Sallapalli, Shaokai Pei, Mohamed Nasr, Cigdem Tosun, Yanjin Zhang, Qiyi Tang, J. Marc Simard, Richard Y. Zhao   +10 more
doaj   +3 more sources

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

Redox Biology, 2023
Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome ...
Siyao Huang, Xiaofang Peng, Hong Peng
exaly   +4 more sources

Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models [PDF]

Vaccines
Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen.
Jacob Meza, Elizabeth Glass, Avinaash K. Sandhu, Yangchen Li, Styliani Karanika, Kaitlyn Fessler, Yinan Hui, Courtney Schill, Tianyin Wang, Jiaqi Zhang, Rowan E. Bates, Alannah D. Taylor, Aakanksha R. Kapoor, Samuel K. Ayeh, Petros C. Karakousis, Richard B. Markham, James T. Gordy   +16 more
doaj   +3 more sources

SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production [PDF]

mBio
The primary challenge posed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19-related mortality, often exacerbated by additional medical complications, such as COVID-19-associated kidney injuries (CAKIs). Up to half of
Chenyu Zhang, Volodymyr Gerzanich, Ruth Cruz-Cosme, Jiantao Zhang, Orest Tsymbalyuk, Cigdem Tosun, Bhargava Teja Sallapalli, Dongxiao Liu, Kaspar Keledjian, John C. Papadimitriou, Cinthia B. Drachenberg, Mohamed Nasr, Yanjin Zhang, Qiyi Tang, J. Marc Simard, Richard Y. Zhao   +15 more
doaj   +3 more sources

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5. [PDF]

MedComm (2020)
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Xie Q, Noettger S, Lawrenz J, Stopper S, Klute S, Münch J, Kmiec D, Wang Q, Sparrer KMJ, Kirchhoff F.   +9 more
europepmc   +2 more sources