Results 1 to 10 of about 6,314 (165)

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis [PDF]

Viruses
The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated ...
Dusan Kunec, Juergen Richt, Franco Matias Ferreyra   +2 more
exaly   +7 more sources

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation [PDF]

Advanced Science
SARS‐CoV‐2 accessory protein ORF3a contributes to viral pathogenesis through membrane remodeling, immune evasion, and inflammation induction. However, the molecular mechanisms underlying ORF3a‐mediated pathogenesis remain poorly characterized, and no ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
doaj   +3 more sources

Variations in Orf3a protein of SARS-CoV-2 alter its structure and function

Biochemistry and Biophysics Reports, 2021
Severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread worldwide and acquired multiple mutations in its genome. Orf3a, an accessory protein encoded by the genome of SARS-CoV-2, plays a significant role in viral infection and ...
Gajendra Kumar Azad, Parimal Khan
exaly   +5 more sources

SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence

Viruses, 2023
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus Disease 2019 (COVID-19). Excessive inflammation is a hallmark of severe COVID-19, and several proteins encoded in the SARS-CoV-2 genome are capable ...
Tsan Xiao, Brianna Busscher, Henock Befekadu   +2 more
exaly   +4 more sources

SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release. [PDF]

mLife
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Qin F, Yan C, Liu Z, Wang D, Zhong H, Ding Q, Chen M, Zhang XE.   +7 more
europepmc   +2 more sources

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5. [PDF]

MedComm (2020)
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Xie Q, Noettger S, Lawrenz J, Stopper S, Klute S, Münch J, Kmiec D, Wang Q, Sparrer KMJ, Kirchhoff F.   +9 more
europepmc   +2 more sources

SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death [PDF]

Communications Biology
The variants of concern (VOCs) of SARS-CoV-2 emerged independently and became dominant globally at different times. Despite the emergence of multiple VOCs, the Delta variant of SARS-CoV-2 showed heightened pathogenicity and unprecedented mortality ...
Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari, Bharadwaj Vemparala, Anantika Chandra, Disha Jain, Narendra M. Dixit, Prasad Tammineni, Sannula Kesavardhana   +8 more
doaj   +2 more sources

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis [PDF]

Frontiers in Immunology
Subgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied.
Yifan Zhang, Jing Li, Xinglong Zhang, Xin Zhang, Jiali Li, Heng Li, Heng Li, Heng Li, Xin Zhao, Xin Zhao, Xin Zhao, Zihan Zhang, Yingyan Li, Keqi Chen, Shasha Peng, Haijing Shi, Haijing Shi, Haijing Shi, Longding Liu, Longding Liu, Longding Liu   +20 more
doaj   +2 more sources

Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein

Viruses, 2021
ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Carol Anne Munro, Dora E Corzo-León, Soumya Palliyil   +2 more
exaly   +3 more sources

A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence

Computational and Structural Biotechnology Journal, 2020
The genome of SARS-CoV-2, the coronavirus responsible for the Covid-19 pandemic, encodes a number of accessory genes. The longest accessory gene, Orf3a, plays important roles in the virus lifecycle indicated by experimental findings, known polymorphisms,
Christos Ouzounis
exaly   +3 more sources