Results 1 to 10 of about 7,628 (191)

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis [PDF]

Viruses
The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated ...
Edward B. Stephens, Dusan Kunec, Wyatt Henke, Ricardo Martin Vidal, Brandon Greishaber, Rabina Saud, Maria Kalamvoki, Gagandeep Singh, Sujan Kafle, Jessie D. Trujillo, Franco Matias Ferreyra, Igor Morozov, Juergen A. Richt   +12 more
doaj   +5 more sources

Variations in Orf3a protein of SARS-CoV-2 alter its structure and function

Biochemistry and Biophysics Reports, 2021
Severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread worldwide and acquired multiple mutations in its genome. Orf3a, an accessory protein encoded by the genome of SARS-CoV-2, plays a significant role in viral infection and ...
Gajendra Kumar Azad, Parimal Kumar Khan
doaj   +5 more sources

Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19

Frontiers in Microbiology, 2022
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-19-related morbidity and mortality, and the high mutability of the virus.
Jiantao Zhang, Jiantao Zhang, Amara Ejikemeuwa, Volodymyr Gerzanich, Volodymyr Gerzanich, Mohamed Nasr, Qiyi Tang, J. Marc Simard, J. Marc Simard, J. Marc Simard, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao   +14 more
doaj   +5 more sources

Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast [PDF]

Frontiers in Microbiology, 2023
Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus ...
José Luis Garrido-Huarte, Josep Fita-Torró, Rosa Viana, Amparo Pascual-Ahuir, Markus Proft   +4 more
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Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein [PDF]

Viruses, 2021
ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan, Elizabeth Patton, Carol A. Munro, Dora E. Corzo-Leon, Andrew J. Porter, Soumya Palliyil   +5 more
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A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis [PDF]

Frontiers in Immunology
Subgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied.
Yifan Zhang, Jing Li, Xinglong Zhang, Xin Zhang, Jiali Li, Heng Li, Heng Li, Heng Li, Xin Zhao, Xin Zhao, Xin Zhao, Zihan Zhang, Yingyan Li, Keqi Chen, Shasha Peng, Haijing Shi, Haijing Shi, Haijing Shi, Longding Liu, Longding Liu, Longding Liu   +20 more
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Loss of orf3b in the circulating SARS-CoV-2 strains [PDF]

Emerging Microbes and Infections, 2020
The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since December 2019 with more than 35 million laboratory confirmed human infections and over one million deaths within nine months.
Joy-Yan Lam, Chun-Kit Yuen, Jonathan Daniel Ip, Wan-Man Wong, Kelvin Kai-Wang To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +3 more sources

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement. [PDF]

PLoS Pathogens, 2015
Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae.
Ekaterina Smirnova, Andrew E Firth, W Allen Miller, Danièle Scheidecker, Véronique Brault, Catherine Reinbold, Aurélie M Rakotondrafara, Betty Y-W Chung, Véronique Ziegler-Graff   +8 more
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Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the AND-System cognitive platform, graph neural networks, and molecular [PDF]

Вавиловский журнал генетики и селекции
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions.
T. V. Ivanisenko, P. S. Demenkov, M. A. Kleshchev, V. A. Ivanisenko   +3 more
doaj   +2 more sources

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

Frontiers in Microbiology, 2021
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, appears to efficiently evade the host immune ...
Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu   +7 more
doaj   +3 more sources