Results 21 to 30 of about 6,314 (165)

Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models [PDF]

Vaccines
Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen.
Jacob Meza, Elizabeth Glass, Avinaash K. Sandhu, Yangchen Li, Styliani Karanika, Kaitlyn Fessler, Yinan Hui, Courtney Schill, Tianyin Wang, Jiaqi Zhang, Rowan E. Bates, Alannah D. Taylor, Aakanksha R. Kapoor, Samuel K. Ayeh, Petros C. Karakousis, Richard B. Markham, James T. Gordy   +16 more
doaj   +3 more sources

Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19

Frontiers in Microbiology, 2022
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-19-related morbidity and mortality, and the high mutability of the virus.
Jiantao Zhang, Jiantao Zhang, Amara Ejikemeuwa, Volodymyr Gerzanich, Volodymyr Gerzanich, Mohamed Nasr, Qiyi Tang, J. Marc Simard, J. Marc Simard, J. Marc Simard, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao   +14 more
doaj   +3 more sources

A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport

Frontiers in Cell and Developmental Biology, 2022
The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Ruth Cruz-Cosme, Jiantao Zhang, Jiantao Zhang, Dongxiao Liu, Vidhyanand Mahase, Bhargava Teja Sallapalli, Peixi Chang, Yanjin Zhang, Shaolei Teng, Richard Y. Zhao, Richard Y. Zhao, Richard Y. Zhao, Qiyi Tang   +12 more
doaj   +3 more sources

SARS-CoV-2 ORF3a Interacts and Stabilizes HMOX1 Expression and Function [PDF]

, 2023
This thesis describes the interaction between SARS-CoV-2 Open Reading Frame 3a (ORF3a) and the Heme Oxygenase 1 (HMOX1). SARS-CoV-2 is a novel coronavirus and the causative agent of COVID-19, the highly contagious infection behind the 2019 COVID-19 ...
Jones, Naomi X
core   +2 more sources

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study [PDF]

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +2 more sources

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1 [PDF]

Computational and Structural Biotechnology Journal, 2022
The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on the severity of the disease ...
Suchetana Gupta, Ditipriya Mallick, Kumarjeet Banerjee, Shrimon Mukherjee, Soumyadev Sarkar, Sonny TM Lee, Partha Basuchowdhuri, Siddhartha S Jana   +7 more
doaj   +3 more sources

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

eLife, 2023
The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus.
Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, Rui Yan, Zhiheng Yu, Dejian Ren, Sebastian E Brauchi, David E Clapham   +13 more
doaj   +6 more sources

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes [PDF]

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang, Hao Sun, Rongjuan Pei, Binli Mao, Zhenyu Zhao, Huihui Li, Yong Lin, Kefeng Lu   +7 more
doaj   +3 more sources

SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle

Nature Communications
SARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 virulence factor ORF3a interacts with the lysosomal tethering factor HOPS complex and ...
Kshitiz Walia, Abhishek Sharma, Sankalita Paul, Priya Chouhan, Gaurav Kumar, Rajesh Ringe, Mahak Sharma, Amit Tuli   +7 more
doaj   +2 more sources

Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the AND-System cognitive platform, graph neural networks, and molecular [PDF]

Вавиловский журнал генетики и селекции
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions.
T. V. Ivanisenko, P. S. Demenkov, M. A. Kleshchev, V. A. Ivanisenko   +3 more
doaj   +2 more sources