Results 21 to 30 of about 6,344 (144)
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. [PDF]
PLoS PathogHuman Cytomegalovirus (HCMV) is a commonly infected double-stranded DNA virus of the β-herpesviridae subfamily that typically establishes lifelong latency or persistent infection following primary infection.
Xia S +8 more
europepmc +2 more sources
A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport
Frontiers in Cell and Developmental Biology, 2022 The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Ruth Cruz-Cosme +2 more
exaly +3 more sources
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction
Virus Research, 2023 Highlights • This study screened twenty SARS-CoV-2 genes by luciferase reporter assay and identified ORF3a as an activator of NF-κB pathway.• ORF3a induces proinflammatory cytokines in the upstream level of IκBα.• ORF3a interacts with IKKb and NEMO and ...
Ying Nie, Jinzhi Cheng, Jiahong Wu
exaly +2 more sources
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
doaj +2 more sources
SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response
Viruses, 2021 In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections.
Xue-Jie Yu, Chuan-Min Zhou
exaly +3 more sources
SARS-CoV-2 ORF3a-Mediated NF-κB Activation Is Not Dependent on TRAF-Binding Sequence
Viruses, 2023 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic of Coronavirus Disease 2019 (COVID-19). Excessive inflammation is a hallmark of severe COVID-19, and several proteins encoded in the SARS-CoV-2 genome are capable ...
Brianna M Busscher +2 more
exaly +3 more sources
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Cell Discovery, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang +7 more
doaj +2 more sources
Viruses, 2021 ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Carol A Munro +2 more
exaly +3 more sources
A live attenuated SARS-CoV-2 vaccine constructed by dual inactivation of NSP16 and ORF3a. [PDF]
EBioMedicineSummary Background Live attenuated vaccines against SARS-CoV-2 activate all phases of host immunity resembling a natural infection and they block viral transmission more efficiently than existing vaccines in human use. In our prior work, we characterised
Ye ZW +16 more
europepmc +2 more sources
A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence
Computational and Structural Biotechnology Journal, 2020 The genome of SARS-CoV-2, the coronavirus responsible for the Covid-19 pandemic, encodes a number of accessory genes. The longest accessory gene, Orf3a, plays important roles in the virus lifecycle indicated by experimental findings, known polymorphisms,
Christos A Ouzounis
exaly +3 more sources