Results 21 to 30 of about 7,628 (191)

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes [PDF]

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang, Hao Sun, Rongjuan Pei, Binli Mao, Zhenyu Zhao, Huihui Li, Yong Lin, Kefeng Lu   +7 more
doaj   +3 more sources

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital role in viral pathogenesis and coronavirus disease 2019 (COVID-19).
Jiantao Zhang, Ruth Cruz-Cosme, Chenyu Zhang, Dongxiao Liu, Qiyi Tang, Richard Y. Zhao   +5 more
doaj   +3 more sources

SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production [PDF]

mBio
The primary challenge posed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19-related mortality, often exacerbated by additional medical complications, such as COVID-19-associated kidney injuries (CAKIs). Up to half of
Chenyu Zhang, Volodymyr Gerzanich, Ruth Cruz-Cosme, Jiantao Zhang, Orest Tsymbalyuk, Cigdem Tosun, Bhargava Teja Sallapalli, Dongxiao Liu, Kaspar Keledjian, John C. Papadimitriou, Cinthia B. Drachenberg, Mohamed Nasr, Yanjin Zhang, Qiyi Tang, J. Marc Simard, Richard Y. Zhao   +15 more
doaj   +2 more sources

SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle

Nature Communications
SARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 virulence factor ORF3a interacts with the lysosomal tethering factor HOPS complex and ...
Kshitiz Walia, Abhishek Sharma, Sankalita Paul, Priya Chouhan, Gaurav Kumar, Rajesh Ringe, Mahak Sharma, Amit Tuli   +7 more
doaj   +2 more sources

Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models [PDF]

Vaccines
Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen.
Jacob Meza, Elizabeth Glass, Avinaash K. Sandhu, Yangchen Li, Styliani Karanika, Kaitlyn Fessler, Yinan Hui, Courtney Schill, Tianyin Wang, Jiaqi Zhang, Rowan E. Bates, Alannah D. Taylor, Aakanksha R. Kapoor, Samuel K. Ayeh, Petros C. Karakousis, Richard B. Markham, James T. Gordy   +16 more
doaj   +2 more sources

Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins. [PDF]

Sci Rep
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is primarily known as a respiratory disease.
Costa M, Wang DW, Zhao KD, Yuan L, Krisko A, Li JY, Outeiro T, Li W.   +7 more
europepmc   +3 more sources

SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response [PDF]

PeerJ, 2023
Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1).
Hannah N. Gruner, Yaohuan Zhang, Kaavian Shariati, Nicholas Yiv, Zicheng Hu, Yuhao Wang, J. Fielding Hejtmancik, Michael T. McManus, Kevin Tharp, Gregory Ku   +9 more
doaj   +2 more sources

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs [PDF]

Nature Structural & Molecular Biology, 2021
SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected patient tissues and plasma. Deletion of 3a in SARS-CoV-1 reduces viral titer and morbidity in mice, suggesting it could be an effective target for vaccines or therapeutics ...
David M. Kern, Ben Sorum, Sonali S. Mali, Christopher M. Hoel, Savitha Sridharan, Jonathan P. Remis, Daniel B. Toso, Abhay Kotecha, Diana M. Bautista, Stephen G. Brohawn   +9 more
openaire   +4 more sources

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2 [PDF]

Virus Research, 2020
AbstractOne of the most important proteins for COVID-19 pathogenesis in SARS-CoV2 is the ORF3a protein which is the largest accessory protein among others accessory proteins coded by coronavirus genome. The major roles of the protein include virulence, infectivity, ion channel activity, morphogenesis and virus release.
Sk. Sarif Hassan, Diksha Attrish, Shinjini Ghosh, Pabitra Pal Choudhury, Bidyut Roy   +4 more
openaire   +2 more sources

Exploring polyamine interactions and binding pockets in SARS-CoV-2 ORF3a

Journal of Molecular Graphics and Modelling, 2023
Ongoing global pandemic caused by coronavirus (COVID-19) requires urgent development of vaccines, treatments, and diagnostic tools. Open reading frame 3a (ORF3a) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered to be a potential drug target for COVID-19 treatment.
Panisak Boonamnaj, R.B. Pandey, Pornthep Sompornpisut   +2 more
openaire   +2 more sources