Results 21 to 30 of about 6,597 (167)

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1 [PDF]

Computational and Structural Biotechnology Journal, 2022
The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on the severity of the disease ...
Suchetana Gupta, Ditipriya Mallick, Kumarjeet Banerjee, Shrimon Mukherjee, Soumyadev Sarkar, Sonny TM Lee, Partha Basuchowdhuri, Siddhartha S Jana   +7 more
doaj   +3 more sources

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes [PDF]

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to escape clearance by host cells is unknown.
Yabin Zhang, Hao Sun, Rongjuan Pei, Binli Mao, Zhenyu Zhao, Huihui Li, Yong Lin, Kefeng Lu   +7 more
doaj   +3 more sources

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

eLife, 2023
The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus.
Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, Rui Yan, Zhiheng Yu, Dejian Ren, Sebastian E Brauchi, David E Clapham   +13 more
doaj   +6 more sources

ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication [PDF]

Frontiers in Cell and Developmental Biology, 2021
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection.
Yafei Qu, Xin Wang, Yunkai Zhu, Weili Wang, Yuyan Wang, Gaowei Hu, Chengrong Liu, Jingjiao Li, Shanhui Ren, Maggie Z. X. Xiao, Zhenshan Liu, Chunxia Wang, Joyce Fu, Yucai Zhang, Ping Li, Rong Zhang, Qiming Liang, Qiming Liang, Qiming Liang   +18 more
doaj   +2 more sources

The SARS coronavirus accessory protein ORF3a rescues potassium conductance in yeast

microPublication Biology
ORF3a is an accessory protein expressed by all human pathogen coronaviruses and is the only accessory protein that strongly affects viral fitness. Its deletion reduces severity in both alpha- and beta-coronaviruses, demonstrating a conserved function ...
Joel C. Rosenbaum, Anne E. Carlson
doaj   +3 more sources

Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the AND-System cognitive platform, graph neural networks, and molecular [PDF]

Вавиловский журнал генетики и селекции
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions.
T. V. Ivanisenko, P. S. Demenkov, M. A. Kleshchev, V. A. Ivanisenko   +3 more
doaj   +2 more sources

Targeting the YXXΦ Motifs of the SARS Coronaviruses 1 and 2 ORF3a Peptides by In Silico Analysis to Predict Novel Virus—Host Interactions

Biomolecules, 2022
The emerging SARS-CoV and SARS-CoV-2 belong to the family of “common cold” RNA coronaviruses, and they are responsible for the 2003 epidemic and the current pandemic with over 6.3 M deaths worldwide.
Athanassios Kakkanas, Eirini Karamichali, Efthymia Ioanna Koufogeorgou, Stathis D. Kotsakis, Urania Georgopoulou, Pelagia Foka   +5 more
doaj   +2 more sources

Non-Synonymous Mutation Analysis of SARS-CoV-2 ORF3a in Indonesia [PDF]

Molecular and Cellular Biomedical Sciences, 2022
Background: The report of mutation sites ORF3a SARS CoV-2 in Indonesia is still limited. Some research showed that mutations in ORF3a protein might alter SARS-CoV-2 pathogenesis.
Christian, Jeanne Elvia, Yuliawuri, Hartiyowidi, Steven, Nathanael, Hartiyowidi Yuliawuri, Nathanael Steven, Jeanne Elvia Christian   +5 more
core   +4 more sources

The role of JNK in the proinflammatory action of the SARS-CoV-2 protein ORF3a [PDF]

Medicinski Podmladak
Introduction: Coronavirus disease 2019 (COVID-19) is a contagious respiratory infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Aranđelović Lena, Mandić Miloš, Vučićević Ljubica, Misirkić Marjanović Maja, Trajković Vladimir   +4 more
doaj   +2 more sources

Channel activity of SARS-CoV-2 viroporin ORF3a inhibited by adamantanes and phenolic plant metabolites

Scientific Reports, 2023
SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam, Christine Adel Sedky, Nancy Osama Turky, Hans-Georg Breitinger, Ulrike Breitinger   +4 more
doaj   +2 more sources