SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response [PDF]
Viruses, 2021 In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections.
Chuan-Min Zhou, Xuejie Yu
exaly +6 more sources
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection.
Rong Zhang, Yafei Qu, Yucai Zhang
exaly +7 more sources
Scientific Reports, 2023 SARS-CoV-2 has been responsible for the major worldwide pandemic of COVID-19. Despite the enormous success of vaccination campaigns, virus infections are still prevalent and effective antiviral therapies are urgently needed.
Marina Sherif Fam +4 more
doaj +4 more sources
Non-Synonymous Mutation Analysis of SARS-CoV-2 ORF3a in Indonesia
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: The report of mutation sites ORF3a SARS CoV-2 in Indonesia is still limited. Some research showed that mutations in ORF3a protein might alter SARS-CoV-2 pathogenesis.
Hartiyowidi Yuliawuri +2 more
doaj +4 more sources
COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels [PDF]
mBioThe coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected individuals with pre-existing medical conditions, such as neurocognitive disorders.
Volodymyr Gerzanich +10 more
doaj +3 more sources
SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis
Redox Biology, 2023 Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome ...
Hong Peng, Siyao Huang, Xiaofang Peng
exaly +5 more sources
SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response [PDF]
PeerJ, 2023 Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1).
Hannah N. Gruner +9 more
doaj +4 more sources
SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]
Communications BiologyORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci +9 more
doaj +4 more sources
Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast [PDF]
Frontiers in Microbiology, 2023 Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus ...
José Luis Garrido-Huarte +4 more
doaj +3 more sources
Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells
Heliyon, 2023 The accessory protein ORF3a, from SARS-CoV-2, plays a critical role in viral infection and pathogenesis. Here, we characterized ORF3a assembly, ion channel activity, subcellular localization, and interactome.
Song Jiao +4 more
doaj +3 more sources