Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a [PDF]
EMBO ReportsHigh levels of “bad” cholesterol increase the risk of cardiovascular disease and are also linked to more severe COVID-19, though the reason has been unclear.
Jennifer M Hayashi +21 more
doaj +4 more sources
COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels [PDF]
mBioThe coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected individuals with pre-existing medical conditions, such as neurocognitive disorders.
Volodymyr Gerzanich +10 more
doaj +3 more sources
SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response [PDF]
PeerJ, 2023 Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1).
Hannah N. Gruner +9 more
doaj +4 more sources
SARS-CoV-2 ORF3a Sensitizes Cells to Ferroptosis via Keap1-NRF2 Axis
Redox Biology, 2023 Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome ...
Changwen Ke, Hong Peng, Siyao Huang
exaly +5 more sources
Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells
Heliyon, 2023 The accessory protein ORF3a, from SARS-CoV-2, plays a critical role in viral infection and pathogenesis. Here, we characterized ORF3a assembly, ion channel activity, subcellular localization, and interactome.
Song Jiao +4 more
doaj +3 more sources
Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast [PDF]
Frontiers in Microbiology, 2023 Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus ...
José Luis Garrido-Huarte +4 more
doaj +3 more sources
A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport
Frontiers in Cell and Developmental Biology, 2022 The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Ruth Cruz-Cosme +12 more
doaj +3 more sources
SARS-CoV-2 ORF3a Interacts and Stabilizes HMOX1 Expression and Function [PDF]
, 2023 This thesis describes the interaction between SARS-CoV-2 Open Reading Frame 3a (ORF3a) and the Heme Oxygenase 1 (HMOX1). SARS-CoV-2 is a novel coronavirus and the causative agent of COVID-19, the highly contagious infection behind the 2019 COVID-19 ...
Jones, Naomi X
core +2 more sources
Nature CommunicationsSARS-CoV-2, the causative agent of COVID-19, uses the host endolysosomal system for entry, replication, and egress. Previous studies have shown that the SARS-CoV-2 virulence factor ORF3a interacts with the lysosomal tethering factor HOPS complex and ...
Kshitiz Walia +7 more
doaj +2 more sources
Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications [PDF]
Advanced Pharmaceutical Bulletin, 2023 Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2.
Minu Treeza M +4 more
doaj +3 more sources