SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response [PDF]
Viruses, 2021 In the past year and a half, SARS-CoV-2 has caused 240 million confirmed cases and 5 million deaths worldwide. Autophagy is a conserved process that either promotes or inhibits viral infections.
Wen-qing Su, Xue-jie Yu, Chuan-min Zhou
doaj +5 more sources
SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis
Redox Biology, 2023 Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome ...
Lihong Liu +14 more
doaj +5 more sources
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection.
Yafei Qu +18 more
doaj +6 more sources
SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling [PDF]
Communications BiologyORF3a, the most abundantly expressed accessory protein of SARS-CoV-2, plays an essential role in virus egress by inactivating lysosomes through their deacidification. However, the mechanism underlying this process remains unclear.
Antonio Michelucci +9 more
doaj +4 more sources
Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells
Heliyon, 2023 The accessory protein ORF3a, from SARS-CoV-2, plays a critical role in viral infection and pathogenesis. Here, we characterized ORF3a assembly, ion channel activity, subcellular localization, and interactome.
Song Jiao +4 more
doaj +3 more sources
D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1 [PDF]
Computational and Structural Biotechnology Journal, 2022 The clinical manifestation of the recent pandemic COVID-19, caused by the novel SARS-CoV-2 virus, varies from mild to severe respiratory illness. Although environmental, demographic and co-morbidity factors have an impact on the severity of the disease ...
Suchetana Gupta +7 more
doaj +3 more sources
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas [PDF]
Viruses, 2021 Recently, two cases of complete remission of classical Hodgkin lymphoma (cHL) and follicular lymphoma (FL) after SARS-CoV-2 infection were reported. However, the precise molecular mechanism of this rare event is yet to be understood. Here, we hypothesize
Debmalya Barh +17 more
doaj +4 more sources
COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels [PDF]
mBioThe coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected individuals with pre-existing medical conditions, such as neurocognitive disorders.
Volodymyr Gerzanich +10 more
doaj +2 more sources
A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport
Frontiers in Cell and Developmental Biology, 2022 The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Ruth Cruz-Cosme +12 more
doaj +3 more sources
Non-Synonymous Mutation Analysis of SARS-CoV-2 ORF3a in Indonesia
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: The report of mutation sites ORF3a SARS CoV-2 in Indonesia is still limited. Some research showed that mutations in ORF3a protein might alter SARS-CoV-2 pathogenesis.
Hartiyowidi Yuliawuri +2 more
doaj +3 more sources