Results 31 to 40 of about 6,344 (144)

Tetherin antagonism by SARS‐CoV ‐2 ORF3a and spike protein enhances virus release

EMBO Reports, 2023
The antiviral restriction factor, tetherin, blocks the release of several different families of enveloped viruses, including the Coronaviridae. Tetherin is an interferon‐induced protein that forms parallel homodimers between the host cell and viral ...
Hazel Stewart, Roberta Palmulli, Kristoffer H Johansen   +2 more
exaly   +2 more sources

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

MBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital role in viral pathogenesis and coronavirus disease 2019 (COVID-19).
Jiantao Zhang, Ruth Cruz-Cosme, Qiyi Tang   +2 more
exaly   +3 more sources

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

Pathogens
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications.
Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J. Marc Simard, Richard Y. Zhao   +9 more
doaj   +2 more sources

Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a

The Microbe
The COVID-19 pandemic caused by SARS-CoV-2 remains an ongoing global health concern. Understanding the roles of SARS-CoV-2 accessory proteins is essential for developing effective therapeutic strategies.
Apoorva, Astha Shukla, Atul Kumar, Saurabh Singh, Sunit K. Singh   +4 more
doaj   +2 more sources

Spatial Transcriptomics and Single Cell-RNASeq Reveals Cellular Heterogeneity of SARS-CoV-2 in Lung Tissues and Global Mutational Patterns in COVID-19 Patients. [PDF]

J Med Virol
ABSTRACT RNA viruses have high mutation frequency, quick generation periods and vast population numbers, which promote fast evolution and host environment adaptation. We integrated scRNA‐seq and spatial transcriptomics to profile immune cells and viral gene expression in COVID‐19.
Hosseini ST, Mahmanzar M, Rahimian K, Bayat S, Gholamzad A, Sisakht MM, Farhadi A, Kuehu DL, Deng Y.   +8 more
europepmc   +2 more sources

SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response [PDF]

PeerJ, 2023
Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1).
Hannah N. Gruner, Yaohuan Zhang, Kaavian Shariati, Nicholas Yiv, Zicheng Hu, Yuhao Wang, J. Fielding Hejtmancik, Michael T. McManus, Kevin Tharp, Gregory Ku   +9 more
doaj   +2 more sources

Some aspects of the life of SARS-CoV-2 ORF3a protein in mammalian cells

Heliyon, 2023
The accessory protein ORF3a, from SARS-CoV-2, plays a critical role in viral infection and pathogenesis. Here, we characterized ORF3a assembly, ion channel activity, subcellular localization, and interactome.
Song Jiao, Pablo Miranda, Yan Li, Dragan Maric, Miguel Holmgren   +4 more
doaj   +1 more source

Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications [PDF]

Advanced Pharmaceutical Bulletin, 2023
Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2.
Minu Treeza M, Sanu Augustine, Aparna Ann Mathew, S.K. Kanthlal, Rajitha Panonummal   +4 more
doaj   +1 more source

Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study

Journal of Tropical Life Science, 2022
In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri, Jeanne Elvia Christian   +1 more
doaj   +1 more source

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

Frontiers in Microbiology, 2021
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, appears to efficiently evade the host immune ...
Rong Wang, Xiaofeng Yang, Mingke Chang, Ziyang Xue, Weirong Wang, Liang Bai, Sihai Zhao, Enqi Liu   +7 more
doaj   +1 more source