Results 31 to 40 of about 6,314 (165)

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

MBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital role in viral pathogenesis and coronavirus disease 2019 (COVID-19).
Jiantao Zhang, Qiyi Tang, Richard Y Zhao   +2 more
exaly   +3 more sources

The role of JNK in the proinflammatory action of the SARS-CoV-2 protein ORF3a [PDF]

Medicinski Podmladak
Introduction: Coronavirus disease 2019 (COVID-19) is a contagious respiratory infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Aranđelović Lena, Mandić Miloš, Vučićević Ljubica, Misirkić Marjanović Maja, Trajković Vladimir   +4 more
doaj   +2 more sources

Targeting the YXXΦ Motifs of the SARS Coronaviruses 1 and 2 ORF3a Peptides by In Silico Analysis to Predict Novel Virus—Host Interactions

Biomolecules, 2022
The emerging SARS-CoV and SARS-CoV-2 belong to the family of “common cold” RNA coronaviruses, and they are responsible for the 2003 epidemic and the current pandemic with over 6.3 M deaths worldwide.
Athanassios Kakkanas, Eirini Karamichali, Efthymia Ioanna Koufogeorgou, Stathis D. Kotsakis, Urania Georgopoulou, Pelagia Foka   +5 more
doaj   +2 more sources

Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein

Biomedicines, 2023
SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release, immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential ORF3a-induced apoptotic and inflammatory death mechanism, lung epithelial cells (A549)
Panagiotis Keramidas, Eleni Papachristou, Rigini M. Papi, Aglaia Mantsou, Theodora Choli-Papadopoulou   +4 more
doaj   +2 more sources

SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production

mBio
The primary challenge posed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19-related mortality, often exacerbated by additional medical complications, such as COVID-19-associated kidney injuries (CAKIs). Up to half of
Chenyu Zhang, Volodymyr Gerzanich, Ruth Cruz-Cosme, Jiantao Zhang, Orest Tsymbalyuk, Cigdem Tosun, Bhargava Teja Sallapalli, Dongxiao Liu, Kaspar Keledjian, John C. Papadimitriou, Cinthia B. Drachenberg, Mohamed Nasr, Yanjin Zhang, Qiyi Tang, J. Marc Simard, Richard Y. Zhao   +15 more
doaj   +2 more sources

Autophagy induction by SARS-CoV-2 ORF3a depends on JNK signaling

SARS-CoV-2 open reading frame 3a (ORF3a) is a non-structural and an accessory protein that is involved in the pathogenesis of COVID-19. ORF3a manipulates with autophagosomes and lysosomal degradation to support SARS-CoV-2 replication and egress.
Trajković, Vladimir, Kosić, Milica, Paunović, Verica, Vučićević, Ljubica, Mandić, Miloš, Bošnjak, Mihajlo, Stevanović, Danijela, Misirkić Marjanović, Maja   +7 more
core   +2 more sources

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

Pathogens
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications.
Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J. Marc Simard, Richard Y. Zhao   +9 more
doaj   +2 more sources

Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a

The Microbe
The COVID-19 pandemic caused by SARS-CoV-2 remains an ongoing global health concern. Understanding the roles of SARS-CoV-2 accessory proteins is essential for developing effective therapeutic strategies.
Apoorva, Astha Shukla, Atul Kumar, Saurabh Singh, Sunit K. Singh   +4 more
doaj   +2 more sources

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs [PDF]

Nature Structural & Molecular Biology, 2021
SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected patient tissues and plasma. Deletion of 3a in SARS-CoV-1 reduces viral titer and morbidity in mice, suggesting it could be an effective target for vaccines or therapeutics ...
David M. Kern, Ben Sorum, Sonali S. Mali, Christopher M. Hoel, Savitha Sridharan, Jonathan P. Remis, Daniel B. Toso, Abhay Kotecha, Diana M. Bautista, Stephen G. Brohawn   +9 more
openaire   +4 more sources

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2 [PDF]

Virus Research, 2020
Abstract One of the most important proteins for COVID-19 pathogenesis in SARS-CoV2 is the ORF3a protein which is the largest accessory protein among others accessory proteins coded by coronavirus genome. The major roles of the protein include virulence, infectivity, ion channel activity, morphogenesis and virus release. The coronavirus,
Sk. Sarif Hassan, Diksha Attrish, Shinjini Ghosh, Pabitra Pal Choudhury, Bidyut Roy   +4 more
openaire   +2 more sources