Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications [PDF]
Advanced Pharmaceutical Bulletin, 2023 Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2.
Minu Treeza M +4 more
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eLife, 2023 The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus.
Alexandria N Miller +13 more
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Epitope mapping of ORF3a Protein SARS-CoV-2 in Indonesia through computational study
Journal of Tropical Life Science, 2022 In Indonesia, the vaccine for SARS-CoV-2 is still being developed. ORF3a protein of SARS-CoV-2 could be a potential peptide to be used in the vaccine, therapeutic antibodies, and diagnostic kit development. We used the computational approach in designing
Hartiyowidi Yuliawuri +1 more
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ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication [PDF]
, 2020 Abstract SARS-CoV-2 is the causative agent for the COVID-19 pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin-1 is an essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 and UVRAG, responsible for autophagosome formation and maturation ...
Yafei Qu +14 more
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Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples
Journal of Clinical and Translational Science, 2021 Background: SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium.
Han-Gang Yu +3 more
doaj +1 more source
ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection [PDF]
Epidemiology and Infection, 2020 Abstract
Majumdar, Parinita, Niyogi, Sougata
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Unique truncated and non-synonymous mutations in functional domains of ORF3a SARS-CoV-2 [PDF]
, 2023 Previous studies showed that mutations in the SARS-CoV-2 ORF3a protein can influence viral pathogenesis. Therefore, it is necessary to observe mutations, especially in the functional domain of the protein.
Christian, Jeanne Elvia +1 more
core +1 more source
SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis
mSystems, 2020 At the surge of the coronavirus disease 2019 (COVID-19) pandemic, we detected and identified six functional domains (I to VI) in the SARS-CoV-2 3a protein. Our analysis showed that the functional domains were linked to virulence, infectivity, ion channel formation, and virus release in SARS-CoV-2 3a. Our study also revealed the functional importance of
Issa, Elio +4 more
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Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution [PDF]
, 2021 Various lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have contributed to prolongation of the coronavirus disease 2019 (COVID-19) pandemic.
Adadi, Parise +20 more
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Using Alphafold2 to Predict the Structure of the Gp5/M Dimer of Porcine Respiratory and Reproductive Syndrome Virus [PDF]
, 2022 Porcine reproductive and respiratory syndrome virus is a positive-stranded RNA virus of the family Arteriviridae. The Gp5/M dimer, the major component of the viral envelope, is required for virus budding and is an antibody target.
Gadalla, Mohamed Rasheed +2 more
core +2 more sources