Results 41 to 50 of about 6,344 (144)

Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast

Frontiers in Microbiology, 2023
Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus ...
José Luis Garrido-Huarte, Josep Fita-Torró, Rosa Viana, Amparo Pascual-Ahuir, Markus Proft   +4 more
doaj   +1 more source

Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples

Journal of Clinical and Translational Science, 2021
Background: SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium.
Han-Gang Yu, Gina Sizemore, Katy Smoot, Peter Perrotta   +3 more
doaj   +1 more source

Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins

Cell Reports, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.
Yun-Bin Lee, Minkyo Jung, Jeesoo Kim, Afandi Charles, Wanda Christ, Jiwoong Kang, Myeong-Gyun Kang, Chulhwan Kwak, Jonas Klingström, Anna Smed-Sörensen, Jong-Seo Kim, Ji Young Mun, Hyun-Woo Rhee   +12 more
doaj   +1 more source

Targeting the YXXΦ Motifs of the SARS Coronaviruses 1 and 2 ORF3a Peptides by In Silico Analysis to Predict Novel Virus—Host Interactions

Biomolecules, 2022
The emerging SARS-CoV and SARS-CoV-2 belong to the family of “common cold” RNA coronaviruses, and they are responsible for the 2003 epidemic and the current pandemic with over 6.3 M deaths worldwide.
Athanassios Kakkanas, Eirini Karamichali, Efthymia Ioanna Koufogeorgou, Stathis D. Kotsakis, Urania Georgopoulou, Pelagia Foka   +5 more
doaj   +1 more source

ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication

Frontiers in Cell and Developmental Biology, 2021
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent for the coronavirus disease 2019 (COVID-19) pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection.
Yafei Qu, Xin Wang, Yunkai Zhu, Weili Wang, Yuyan Wang, Gaowei Hu, Chengrong Liu, Jingjiao Li, Shanhui Ren, Maggie Z. X. Xiao, Zhenshan Liu, Chunxia Wang, Joyce Fu, Yucai Zhang, Ping Li, Rong Zhang, Qiming Liang, Qiming Liang, Qiming Liang   +18 more
doaj   +1 more source

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

Nature Structural & Molecular Biology, 2021
SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected patient tissues and plasma.
D. Kern, B. Sorum, Sonali S. Mali, C. M. Hoel, Savitha Sridharan, J. Remis, D. Toso, A. Kotecha, D. Bautista, S. Brohawn   +9 more
semanticscholar   +1 more source

Loss of orf3b in the circulating SARS-CoV-2 strains

Emerging Microbes and Infections, 2020
The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since December 2019 with more than 35 million laboratory confirmed human infections and over one million deaths within nine months.
Joy-Yan Lam, Chun-Kit Yuen, Jonathan Daniel Ip, Wan-Man Wong, Kelvin Kai-Wang To, Kwok-Yung Yuen, Kin-Hang Kok   +6 more
doaj   +1 more source

Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein

Biomedicines, 2023
SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release, immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential ORF3a-induced apoptotic and inflammatory death mechanism, lung epithelial cells (A549)
Panagiotis Keramidas, Eleni Papachristou, Rigini M. Papi, Aglaia Mantsou, Theodora Choli-Papadopoulou   +4 more
doaj   +1 more source

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Cellular & Molecular Immunology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus Betacoronavirus of the Coronaviridae family, which includes SARS-CoV and Middle East respiratory ...
Yujie Ren, T. Shu, Di Wu, Jingfang Mu, Chong Wang, Muhan Huang, Yang Han, Xueyi Zhang, W. Zhou, Y. Qiu, Xi Zhou   +10 more
semanticscholar   +1 more source

Open Reading Frame-3a gene of the 2019 novel coronavirus inhibits the occurrence and development of colorectal cancer

Discover Oncology, 2022
Highlights 1. ORF3a was successfully transfected into SW480 cells, and its expression was localized in the cytoplasm of SW480 cells. 2. ORF3a inhibited SW480 cell proliferation, invasion and migration, induced their apoptosis, and blocked them in the G1 ...
Han Shuwen, Wu Yinhang, Mao Jing, Chen Gong, Hou Xiaohui, Yang Xi, Wu Wei   +6 more
doaj   +1 more source