Targeting Viral ORF3a Protein: A New Approach to Mitigate COVID-19 Induced Immune Cell Apoptosis and Associated Respiratory Complications [PDF]
Advanced Pharmaceutical Bulletin, 2023 Infection with SARS-CoV-2 is a growing concern to the global well-being of the public at present. Different amino acid mutations alter the biological and epidemiological characteristics, as well as immune resistance of SARS-CoV-2.
Minu Treeza M +4 more
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Endomembrane Systems are Reorganized by ORF3a and Membrane (M) of SARS-CoV-2 [PDF]
SSRN Electronic Journal, 2020 Summary The endomembrane reticulum (ER) is largely reorganized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 ORF3a and membrane (M) protein expression affects ER-derived structures including cubic membrane and double membrane vesicles in coronavirus-infected cells; however, the molecular mechanisms ...
Yun-Bin Lee +7 more
openaire +1 more source
ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infection [PDF]
Epidemiology and Infection, 2020 Abstract
Majumdar, Parinita, Niyogi, Sougata
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Theoretical and experimental study of interaction of macroheterocyclic compounds with ORF3a of SARS-CoV-2 [PDF]
Scientific Reports, 2021 AbstractThe pandemic infectious disease (Covid-19) caused by the coronavirus (SARS-CoV2) is spreading rapidly around the world. Covid-19 does an irreparable harm to the health and life of people. It also has a negative financial impact on the economies of most countries of the world.
Natalia Sh. Lebedeva +8 more
openaire +3 more sources
Frontiers in Microbiology, 2021 Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen of COVID-19, appears to efficiently evade the host immune ...
Rong Wang +7 more
doaj +1 more source
SARS-CoV-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast
, 2022 Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The SARS-CoV-2 small accessory proteins ORF3a and ORF7a have been implicated in favoring virus replication and spreading by inhibiting the autophagic ...
Pascual-Ahuir, Amparo +3 more
core +1 more source
Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples
Journal of Clinical and Translational Science, 2021 Background: SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium.
Han-Gang Yu +3 more
doaj +1 more source
Image3_A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport.TIF
, 2022 The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Bhargava Teja Sallapalli (14163438) +9 more
core +1 more source
Unraveling the impact of ORF3a Q57H mutation on SARS-CoV-2: insights from molecular dynamics
, 2023 ORF3a is a conserved accessory protein of SARS-CoV-2, linked to viral infection and pathogenesis, with acquired mutations at various locations. Previous studies have shown that the occurrence of the Q57H mutation is higher in comparison to other ...
Md. Jahirul Islam (2567767) +7 more
core +2 more sources
SARS-CoV-2 Orf3a protein interaction mapping using unnatural amino acid incorporation. [PDF]
Protein Eng Des SelMapping transient protein–protein interactions remain a major challenge in studying viral host–pathogen interfaces. While some virus-host interactions are stable and readily captured, the majority are highly dynamic, reflecting the need for a small ...
Lundrigan E, Ahmed N, Pezacki JP.
europepmc +2 more sources