Results 61 to 70 of about 6,314 (165)
mBio, 2022 Therapeutic inhibition of critical viral functions is important for curtailing coronavirus disease 2019 (COVID-19). We sought to identify antiviral targets through the genome-wide characterization of severe acute respiratory syndrome coronavirus 2 (SARS ...
Jiantao Zhang +6 more
doaj +1 more source
Table1_A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport.docx
, 2022 The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Bhargava Teja Sallapalli (14163438) +9 more
core +1 more source
SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis
, 2009 The SARS coronavirus (CoV) positive-stranded RNA viral genome encodes 14 open reading frames (ORFs), eight of which encode proteins termed as “accessory proteins.” These proteins help the virus infect the host and promote virulence. In this chapter we describe some of our latest investigations into the structure and function of two such accessory ...
Lu, Wei, Xu, Ke, Sun, Bing
openaire +1 more source
Discover Oncology, 2022 Highlights 1. ORF3a was successfully transfected into SW480 cells, and its expression was localized in the cytoplasm of SW480 cells. 2. ORF3a inhibited SW480 cell proliferation, invasion and migration, induced their apoptosis, and blocked them in the G1 ...
Han Shuwen +6 more
doaj +1 more source
Loss of orf3b in the circulating SARS-CoV-2 strains
Emerging Microbes and Infections, 2020 The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since December 2019 with more than 35 million laboratory confirmed human infections and over one million deaths within nine months.
Joy-Yan Lam +6 more
doaj +1 more source
Unique truncated and non-synonymous mutations in functional domains of ORF3a SARS-CoV-2
, 2023 Previous studies showed that mutations in the SARS-CoV-2 ORF3a protein can influence viral pathogenesis. Therefore, it is necessary to observe mutations, especially in the functional domain of the protein.
Christian, Jeanne Elvia +1 more
core +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
COULD PRE-EXISTING ORF3A IMMUNITY FROM PRIOR CORONAVIRUS INFECTIONS PROTECT AGAINST SEVERE COVID-19?
, 2022 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the virus responsible for the ongoing COVID-19 pandemic and the cause of over 5 million deaths worldwide.
Sievers, Benjamin
core +1 more source
F1000ResearchBackground Mutations in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enhance its pathogenicity by affecting its transmissibility, disease severity, and overall mortality in human populations.
Jin O-Uchi +10 more
doaj +1 more source
Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement. [PDF]
PLoS Pathogens, 2015 Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae.
Ekaterina Smirnova +8 more
doaj +1 more source