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Genomic Surveillance of SARS‐CoV‐2 in Senegal (2020–2024): Variant Turnover, Omicron Introductions, and Interregional Spread

Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.
ABSTRACT Background Genomic surveillance is central to tracking SARS‐CoV‐2 evolution, variant replacement, and transmission dynamics. In Senegal, the Institut Pasteur de Dakar generated one of the largest national longitudinal SARS‐CoV‐2 genomic datasets, offering a unique view of viral spread from the first pandemic wave to the post‐Omicron period ...
Ndeye Awa Ndiaye +21 more
wiley +1 more source

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

bioRxiv, 2023
Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of the COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial ...
B. D. López-Ayllón +21 more
semanticscholar +1 more source

Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission

Microbiology Spectrum, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide coronavirus disease 2019 (COVID-19) pandemic. Despite the high efficacy of the authorized vaccines, there may be uncertain and unknown side effects or disadvantages ...
Chengjin Ye +13 more
doaj +1 more source

When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars‐Cov‐2‐Induced Neurodegeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne +4 more
wiley +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba +4 more
wiley +1 more source

SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis

The FASEB Journal, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes injury to multiple organ systems, including the brain. SARS‐CoV‐2's neuropathological mechanisms may include systemic inflammation and hypoxia, as well as direct cell damage ...
Hongling Zhu +11 more
semanticscholar +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu +5 more
wiley +1 more source

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC

The FASEB Journal, 2019
Severe acute respiratory syndrome Coronavirus (SARS‐CoV) is capable of inducing a storm of proinflammatory cytokines. In this study, we show that the SARS‐CoV open reading frame 3a (ORF3a) accessory protein activates the NLRP3 inflammasome by promoting ...
Kam-Leung Siu +10 more
semanticscholar +1 more source

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Signal Transduction and Targeted Therapy, 2021
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying the SARS-
Mingfu Tian +17 more
doaj +1 more source

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

iScience, 2021
Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of ...
Thushan I. de Silva +1012 more
doaj +1 more source

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