Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution. [PDF]
, 2021 At least six small alternative-frame open reading frames (ORFs) overlapping well-characterized SARS-CoV-2 genes have been hypothesized to encode accessory proteins.
Ardern, Zachary +11 more
core +2 more sources
Heterogeneous Evolution Among SARS-CoV-2 Genes and Variants of Concern. [PDF]
J Med VirolABSTRACT Challenges persist regarding the influence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) on public health, with growing interest in future viral molecular variants. In this context, accurate predictions demand a thorough understanding of the virus's molecular evolution, especially proteins targeted by therapies, where ...
González-Vázquez LD +3 more
europepmc +2 more sources
A molecular arms race between host innate antiviral response and emerging human coronaviruses [PDF]
, 2016 Coronaviruses have been closely related with mankind for thousands of years. Communityacquired human coronaviruses have long been recognized to cause common cold.
Jin, D, Lui, PY, Wong, LYR
core +1 more source
Discover Oncology, 2022 Highlights 1. ORF3a was successfully transfected into SW480 cells, and its expression was localized in the cytoplasm of SW480 cells. 2. ORF3a inhibited SW480 cell proliferation, invasion and migration, induced their apoptosis, and blocked them in the G1 ...
Han Shuwen +6 more
doaj +1 more source
mBio, 2022 Therapeutic inhibition of critical viral functions is important for curtailing coronavirus disease 2019 (COVID-19). We sought to identify antiviral targets through the genome-wide characterization of severe acute respiratory syndrome coronavirus 2 (SARS ...
Jiantao Zhang +6 more
doaj +1 more source
SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. [PDF]
PLoS PathogHuman Cytomegalovirus (HCMV) is a commonly infected double-stranded DNA virus of the β-herpesviridae subfamily that typically establishes lifelong latency or persistent infection following primary infection. The regulation of HCMV latency and reactivation is governed by the chromatin structure at the viral major immediate early promoter (MIEP) within ...
Xia S +8 more
europepmc +3 more sources
Structural biology of coronavirus ion channels [PDF]
, 2021 Viral infection compromises specific organelles of the cell and readdresses its functional resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive-sense single-stranded RNA encodes proteins involved in replication, and
Barrantes, Francisco Jose
core +1 more source
Isolation and partial characterization of bacteriophages infecting Pseudomonas syringae pv. actinidiae, causal agent of kiwifruit bacterial canker [PDF]
, 2014 The phytopathogen Pseudomonas syringae pv. actinidiae (Psa) is the causal agent of bacterial canker of kiwifruit. In the last years, it has caused severe economic losses to Actinidia spp. cultivations, mainly in Italy and New Zealand.
Ackermann +45 more
core +1 more source
Phyloepidemiology and adaptive evolution of SARS-CoV2 during the first and second wave of COVID-19 in India [PDF]
, 2023 Introduction. This study aimed to identify the circulating lineages of SARS-CoV-2, prevalent mutations in these lineages, and the selective pressure on the genome of SARS-CoV-2 during the first and second waves of the COVID-19 pandemic in India. Methods.
Kumar, Rajesh +2 more
core +2 more sources
The NANOGrav 11 Year Data Set: Pulsar-timing Constraints on the Stochastic Gravitational-wave Background [PDF]
, 2018 We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav).
A. Brazier +61 more
core +3 more sources