Results 81 to 90 of about 6,344 (144)

“Fertile” Mutations in SARS‐CoV‐2 RNA More Frequently Occurred in Hairpin Loops That Determine Virus Evolution

APMIS, Volume 133, Issue 12, December 2025.
ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson, Pierre Pontarotti, Jacques Fantini, Anthony Levasseur, Christian Devaux, Didier Raoult   +5 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Cucurbit aphid‐borne yellows virus: A growing but overlooked threat to global cucurbit production

Annals of Applied Biology, Volume 187, Issue 3, Page 318-329, November 2025.
Cucurbit aphid‐borne yellows virus (CABYV) presents a significant threat to cucurbit crops worldwide. In this description of a plant virus we review what is currently known about this plant virus. Abstract Cucurbit aphid‐borne yellows virus (CABYV) presents a significant threat to cucurbit crops worldwide.
M. P. Rabadán, Véronique Brault, Veronica Truniger   +2 more
wiley   +1 more source

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

Developmental Cell, 2020
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert it for their replication and release.
Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Y. Bi, Peihui Wang, Hong Zhang   +8 more
semanticscholar   +1 more source

Novel Mechanism of the L‐Type Voltage‐Gated Channels/Calpains Axis in Influenza A Virus‐Induced Autophagosome Activity

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
Hannah Murphy, Hinh Ly
wiley   +1 more source

SARS-CoV-2-ORF3a variant Q57H reduces its pro-apoptotic activity in host cells

F1000Research
Background Mutations in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enhance its pathogenicity by affecting its transmissibility, disease severity, and overall mortality in human populations.
Maria Landherr, I. Polina, M. Cypress, Brian Rhee, Kye-Im Jeon, Sanjana Chandran, Isabel Chaput, Bridget Nieto, Y. Bae, B. Jhun, Jin O-Uchi   +10 more
semanticscholar   +1 more source

SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids

bioRxiv
SARS-CoV-2 infection poses a significant risk to placental physiology, but its impact on placental homeostasis is not well understood. We and others have previously shown that SARS-CoV-2 can colonize maternal and fetal placental cells, yet the specific ...
Deepak Kumar, R. Karvas, Brittany R. Jones, Eliza R. McColl, Emily Diveley, Sukanta Jash, Surendra Sharma, Jeannie C. Kelly, T. Theunissen, I. Mysorekar   +9 more
semanticscholar   +1 more source

Identification of a new ORF3a-E fusion subgenomic RNA of SARS-CoV-2 and its biological features in the infection process

bioRxiv
Subgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied.
Yifan Zhang, Huiwen Zheng, Jing Li, Xing-Wang Zhang, Xin Zhang, Jiali Li, Heng Li, Xin Zhao, Zihan Zhang, Yingyan Li, Keqi Chen, Shasha Peng, Ying Zhang, Hai-Yan Shi, Longding Liu   +14 more
semanticscholar   +1 more source

Exosomal ORF3a mediates lung-liver axis to dysregulate hepatic lipid metabolism in mild COVID-19. [PDF]

Cell Discov
Qu Y, Zhou J, Wang X, Dong S, Li J, Qiu L, Bian L, Yuan W, Xie Q, Qu J, Zhao Z, Wu X, Liang Q.   +12 more
europepmc   +1 more source

Distinct mutational landscapes and phylogenomic insights of the SARS-CoV-2 delta variant in Pakistan and India: Regional evolution, novel mutations, and epidemiological implications. [PDF]

PLoS One
Fiaz N, Basheer A, Zahoor I, Naveed S, Yaqub T.   +4 more
europepmc   +1 more source