Results 81 to 90 of about 6,314 (165)

The SARS coronavirus accessory protein ORF3a rescues potassium conductance in yeast

microPublication biology
ORF3a is an accessory protein expressed by all human pathogen coronaviruses and is the only accessory protein that strongly affects viral fitness. Its deletion reduces severity in both alpha- and beta-coronaviruses, demonstrating a conserved function across the superfamily.
Rosenbaum, Joel C., Carlson, Anne E.
openaire   +2 more sources

Genomic Surveillance of SARS‐CoV‐2 in Senegal (2020–2024): Variant Turnover, Omicron Introductions, and Interregional Spread

Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.
ABSTRACT Background Genomic surveillance is central to tracking SARS‐CoV‐2 evolution, variant replacement, and transmission dynamics. In Senegal, the Institut Pasteur de Dakar generated one of the largest national longitudinal SARS‐CoV‐2 genomic datasets, offering a unique view of viral spread from the first pandemic wave to the post‐Omicron period ...
Ndeye Awa Ndiaye, Safiétou Sankhe, Mamadou Malado Jallow, Mouhamed Kane, Khadidiatou Ndour, Amadou Diallo, Maimouna Mbanne, Ndeye Marième Top, Seynabou Mbaye Ba Souna Diop, Madeleine Dieng, Issa Gnasse, Debora Goudiaby, Cheikh Talla, Mamadou Aliou Barry, Oumar Faye, Ousmane Faye, Cheikh Loucoubar, Amadou Alpha Sall, Gamou Fall, Marie Henriette Dior Ndione, Moussa Moïse Diagne, Ndongo Dia   +21 more
wiley   +1 more source

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Signal Transduction and Targeted Therapy, 2021
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying the SARS-
Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu   +17 more
doaj   +1 more source

When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars‐Cov‐2‐Induced Neurodegeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne, Loet Coenen, Erik Nutma, Jinte Middeldorp, Magdalena J. Lorenowicz   +4 more
wiley   +1 more source

A single Omicron mutation reshapes ORF3a-driven host-cell remodelling

SARS-CoV-2 ORF3a remodels host membranes, but the structural basis and metabolic consequences of this process remain unclear. Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying ...
Ana de Lucas-Rius, Raúl Fernández-Rodríguez, Juozas Grigas, Juan J. Garrido, Kevin Mamprin, Unai Merino-Herrán, Camila Scagnetti Zambrano, María Montoya, Noa B. Martín-Cófreces, Tránsito García-García, Laura Mendoza-García, Juan M. Falcón-Pérez, Miguel Padilla-Blanco, María A. Oliva, Oscar Fernández, Ana J. Pérez-Berná, Francisco J. Chichón, Oihane E. Albóniga, Blanca D. López-Ayllón, Jorge Montesinos   +19 more
core   +1 more source

Examining the feasibility of replacing ORF3a with fluorescent genes to construct SARS-CoV-2 reporter viruses. [PDF]

J Gen Virol
Fastq data associated with the JGV publication " Examining the feasibility of replacing ORF3a with fluorescent genes to construct SARS-CoV-2 reporter ...
Webb I, Erdmann M, Milligan R, Savage M, Matthews DA, Davidson AD.   +5 more
europepmc   +3 more sources

Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins

Signal Transduction and Targeted Therapy, 2021
The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic, leading to millions of infections and hundreds of thousands of human deaths. The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate ...
Yajuan Rui, Jiaming Su, Si Shen, Ying Hu, Dingbo Huang, Wenwen Zheng, Meng Lou, Yifei Shi, Meng Wang, Shiqi Chen, Na Zhao, Qi Dong, Yong Cai, Rongzhen Xu, Shu Zheng, Xiao-Fang Yu   +15 more
doaj   +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and
Chia-Ming Su, Leyi Wang, Dongwan Yoo
doaj   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source