Results 91 to 100 of about 6,314 (165)

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells [PDF]

Cellular & Molecular Immunology, 2020
Ren, Yujie, Shu, Ting, Wu, Di, Mu, Jingfang, Wang, Chong, Huang, Muhan, Han, Yang, Zhang, Xue-Yi, Zhou, Wei, Qiu, Yang, Zhou, Xi   +10 more
openaire   +2 more sources

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 [PDF]

, 2023
1 p.Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of COVID-19. However, the impacts of individual accessory proteins on host cell metabolic pathways are unknown.Here, SARS-CoV-2
Grigas, Juozas, Luque, Daniel, Lozano, Juan José, Villalba, José Manuel, Marín, Silvia, Cascante, Marta, García-García, Tránsito, Foguet, Carles, Mandracchia, Biagio, Mendoza, Laura, Thomson, Timothy M., Redondo, Natalia, Megías, Diego, Calvet, Alba, Farinas Fernández, Marcos, Montoya, María, Fernández-Rodríguez, Raúl, Garrido, Juan J., Lucas-Rius, Ana de, Rodríguez Gómez, María Josefa, Calvo, Cristina, López-Ayllón, Blanca D.   +21 more
core  

An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes

BMC Infectious Diseases, 2023
Background The corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as non-structural, accessory, and structural proteins.
Rabia Nawaz, Muhammad Ali Arif, Zainab Ahmad, Ammara Ahad, Muhammad Shahid, Zohal Hassan, Ali Husnain, Ali Aslam, Muhammad Saad Raza, Uqba Mehmood, Muhammad Idrees   +10 more
doaj   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

N‐Acylethanolamine Acid Amidase Inhibition Reduces SARS‐CoV‐2 Infection in Human Precision Cut‐Lung Slices and Downregulates NF‐KBB Signalling

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT SARS‐CoV‐2, like other positive‐sense RNA viruses, manipulates host lipid metabolism to facilitate its replication by enhancing lipogenesis and lipid droplet formation. This infection disrupts bioactive lipid levels associated with the inflammatory response by increasing nuclear factor‐κB (NF‐κB) transcription.
Veronica La Rocca, Carolina Filipponi, Viktoria Diesendorf, Alessandro De Carli, Giulia Sciandrone, Silvia Nottoli, Erika Plicanti, Rossella Fonnesu, Elena Iacono, Alessandro Mengozzi, Stefano Masi, Paola Lenzi, Francesco Fornai, Katherina Sewald, Helena Obernolte, Roberto Angelini, Jochen Bodem, Giulia Freer, Mauro Pistello, Michele Lai   +19 more
wiley   +1 more source

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10. [PDF]

Antiviral signaling, immune response and cell metabolism are dysregulated by SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic ...
Merino Herrán, Unai, Luque, Daniel, Mendoza-García, Laura, Lozano, Juan José, Megías, D, Fariñas Fernández, Marco, Mendoza-García, L, Cascante i Serratosa, Marta, Lozano, JJ, Fernández, MF, Fernández-Rodríguez, R, Villalba, JM, Garrido, Juan J., de Lucas-Rius, Ana, Herrán, UM, Calvo, C, Grigas, Juozas, Villalba, José Manuel, Cascante, Marta, Thomson, TM, Garrido, JJ, García-García, Tránsito, Foguet, Carles, Cascante, M, Redondo, Natalia, Megías, Diego, García-García, T, Marin, Silvia, Calvet, A, Marín Martínez, Silvia, Thomson, Timothy M., Farinas Fernández, Marcos, Montoya, María, Fernández-Rodríguez, Raúl, de Lucas-Rius, A, Luque, D, Montoya, M, Calvo, Cristina, López-Ayllón, Blanca D., Marin, S, Grigas, J, Redondo, N, Lozano Salvatella, Juan José, López-Ayllón, BD, Luque Buzo, Daniel ; https://orcid.org/, Mandracchia, Biagio, Foguet, C, Mendoza, Laura, Mandracchia, B, Calvet, Alba, Lucas-Rius, Ana de, Rodríguez Gómez, María Josefa, Gómez, MJR   +52 more
core   +6 more sources

The neutrophil‐to‐lymphocyte ratio as a marker of immunosenescence and COVID‐19 outcomes in the elderly: A narrative review

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract Older adults are highly vulnerable to severe COVID‐19. Unlike our previous work on broad immunosenescence, this review focuses on peripheral hematological markers as practical indicators of risk. To examine lymphopenia, neutrophilia, and the neutrophil‐to‐lymphocyte ratio (NLR) as clinically accessible markers of immune aging and COVID‐19 ...
Maha Gasmi, Kimia Torabinasab, Ruth Williams‐Hooker, Santo Marsigliante, Antonella Muscella   +4 more
wiley   +1 more source

Evaluation of Antigen Expression and Early Immune Response Following Cutaneous Suction‐Mediated DNA Delivery

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
In vivo suction‐based cutaneous DNA vaccination promotes robust immunogenic responses. The spatiotemporal patterns of antigen expression following suction‐based SARS‐CoV‐2 DNA vaccine delivery are evaluated in rat skin via immunofluorescence staining.
Nandita C. Jhumur, Yukyung Um, Sarah H. Park, Emran O. Lallow, Christine C. Roberts, Jerry W. Shan, Jonathan P. Singer, Jeffrey D. Zahn, Young K. Park, Lisa K. Denzin, David I. Shreiber, Joel N. Maslow, Hao Lin   +12 more
wiley   +1 more source

Genomic and Phylogenetic Dissection of SARS‐CoV‐2 Transmission Networks in Healthcare Workers

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Understanding how SARS‐CoV‐2 circulates among healthcare workers (HCWs) is critical for maintaining safe hospitals and protecting communities. We retrospectively examined 93 archived nasopharyngeal swabs collected from SARS‐CoV‐2 positive HCWs and their close contacts at a Turkish university hospital between March 2020 and November 2021.
Irmak Güzel, Ayça Arzu Sayıner, Özgür Appak, Ayşe Banu Demir, Ahmet Naci Emecen, Gül Ergör, Belgin Ünal, Oya Özlem Eren-Kutsoylu, Kemal Can Tertemiz, Yusuf Hakan Abacıoğlu, Han T.N Nguyen   +10 more
wiley   +1 more source