Results 71 to 80 of about 6,344 (144)
Advanced Science, Volume 13, Issue 13, 3 March 2026.This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao +5 more
wiley +1 more source
Signal Transduction and Targeted Therapy, 2021 The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic, leading to millions of infections and hundreds of thousands of human deaths. The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate ...
Yajuan Rui +15 more
doaj +1 more source
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 3, February 2026.Abstract Older adults are highly vulnerable to severe COVID‐19. Unlike our previous work on broad immunosenescence, this review focuses on peripheral hematological markers as practical indicators of risk. To examine lymphopenia, neutrophilia, and the neutrophil‐to‐lymphocyte ratio (NLR) as clinically accessible markers of immune aging and COVID‐19 ...
Maha Gasmi +4 more
wiley +1 more source
Scientific Reports, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and
Chia-Ming Su, Leyi Wang, Dongwan Yoo
doaj +1 more source
Advanced Therapeutics, Volume 9, Issue 1, January 2026.In vivo suction‐based cutaneous DNA vaccination promotes robust immunogenic responses. The spatiotemporal patterns of antigen expression following suction‐based SARS‐CoV‐2 DNA vaccine delivery are evaluated in rat skin via immunofluorescence staining.
Nandita C. Jhumur +12 more
wiley +1 more source
BMC Infectious Diseases, 2023 Background The corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as non-structural, accessory, and structural proteins.
Rabia Nawaz +10 more
doaj +1 more source
Genomic and Phylogenetic Dissection of SARS‐CoV‐2 Transmission Networks in Healthcare Workers
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Understanding how SARS‐CoV‐2 circulates among healthcare workers (HCWs) is critical for maintaining safe hospitals and protecting communities. We retrospectively examined 93 archived nasopharyngeal swabs collected from SARS‐CoV‐2 positive HCWs and their close contacts at a Turkish university hospital between March 2020 and November 2021.
Irmak Güzel +10 more
wiley +1 more source
Advanced Functional Materials, Volume 35, Issue 51, December 16, 2025.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras +19 more
wiley +1 more source
Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
PLoS ONE, 2021 COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic.
Manna Zhang +3 more
doaj +1 more source