Results 71 to 80 of about 6,314 (165)

Inhibition of SARS-CoV-2 Viral Channel Activity Using FDA-Approved Channel Modulators Independent of Variants

Biomolecules, 2022
Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu, Gina Sizemore, Ivan Martinez, Peter Perrotta   +3 more
doaj   +1 more source

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication [PDF]

, 2020
Abstract SARS-CoV-2 is the causative agent for the COVID-19 pandemic and there is an urgent need to understand the cellular response to SARS-CoV-2 infection. Beclin-1 is an essential scaffold autophagy protein that forms two distinct subcomplexes with modulators Atg14 and UVRAG, responsible for autophagosome formation and maturation ...
Yafei Qu, Xin Wang, Yunkai Zhu, Yuyan Wang, Xing Yang, Gaowei Hu, Chengrong Liu, Jingjiao Li, Shanhui Ren, Zixuan Xiao, Zhenshan Liu, Weili Wang, Ping Li, Rong Zhang, Qiming Liang   +14 more
openaire   +2 more sources

Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas

Viruses, 2021
Recently, two cases of complete remission of classical Hodgkin lymphoma (cHL) and follicular lymphoma (FL) after SARS-CoV-2 infection were reported. However, the precise molecular mechanism of this rare event is yet to be understood. Here, we hypothesize
Debmalya Barh, Sandeep Tiwari, Lucas Gabriel Rodrigues Gomes, Marianna E. Weener, Khalid J. Alzahrani, Khalaf F. Alsharif, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Kenneth Lundstrom, Sk. Sarif Hassan, Ángel Serrano-Aroca, Kazuo Takayama, Preetam Ghosh, Elrashdy M. Redwan, Bruno Silva Andrade, Siomar de Castro Soares, Vasco Azevedo, Vladimir N. Uversky   +17 more
doaj   +1 more source

Detection and molecular characterisation of beet chlorosis virus in sugar beet in the Czech Republic

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Beet chlorosis virus (BChV) was detected for the first time in Czech sugar beet, and its diversity was assessed. One‐enzyme RTX‐PCR screened 37 symptomatic plants from 15 fields, and BChV was found in 12 plants. Twelve isolates were confirmed by Sanger sequencing of the readthrough domain (RTD), while one representative isolate was sequenced by high ...
Emad Ibrahim, Ali Pasha, Heiko Ziebell, Marie Maňasová, Pavel Ryšánek, Jiban K. Kundu   +5 more
wiley   +1 more source

Potato leafroll virus: A re‐emerging threat to sustainable potato production

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Potato leafroll virus (PLRV) is a positive‐strand RNA virus. Virus particles of PLRV are isometric, 24 nm in diameter. PLRV is the causal agent of leafroll disease in potato (Solanum tuberosum L.) which causes significant losses in yield and quality of potato tubers.
Eugene V. Ryabov, Andrew Love, Lesley Torrance   +2 more
wiley   +1 more source

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation. [PDF]

PLoS Pathog
Human Cytomegalovirus (HCMV) is a commonly infected double-stranded DNA virus of the β-herpesviridae subfamily that typically establishes lifelong latency or persistent infection following primary infection.
Xia S, Huo X, Liu N, Liu X, Wang T, Guo M, Zeng C, Wan P, Chen J.   +8 more
europepmc   +3 more sources

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Immunization with Recombinant Accessory Protein-Deficient SARS-CoV-2 Protects against Lethal Challenge and Viral Transmission

Microbiology Spectrum, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide coronavirus disease 2019 (COVID-19) pandemic. Despite the high efficacy of the authorized vaccines, there may be uncertain and unknown side effects or disadvantages ...
Chengjin Ye, Jun-Gyu Park, Kevin Chiem, Piyush Dravid, Anna Allué-Guardia, Andreu Garcia-Vilanova, Paula Pino Tamayo, Vinay Shivanna, Amit Kapoor, Mark R. Walter, James J. Kobie, Richard K. Plemper, Jordi B. Torrelles, Luis Martinez-Sobrido   +13 more
doaj   +1 more source