Results 71 to 80 of about 7,628 (191)
SARS‐CoV‐2 ORF3a inhibits cGAS‐STING‐mediated autophagy flux and antiviral function
Journal of Medical Virology, 2022 AbstractRecognizing aberrant cytoplasmic dsDNA and stimulating cGAS‐STING‐mediated innate immunity is essential for the host defense against viruses. Recent studies have reported that SARS‐CoV‐2 infection, responsible for the COVID‐19 pandemic, triggers cGAS‐STING activation.
Jiaming Su +9 more
openaire +2 more sources
SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity. [PDF]
Nat CommunAbstract SARS-CoV-2 uses the double-membrane vesicles as replication organelles. However, how virion assembly occurs has not been fully understood. Here we identified a SARS-CoV-2-driven membrane structure named the 3a dense body (3DB). 3DBs have unusual electron-dense and dynamic inner structures, and their formation is driven by the accessory
Hartmann S +4 more
europepmc +5 more sources
A Bioinformatics Approach to Investigate Structural and Non-Structural Proteins in Human Coronaviruses [PDF]
, 2022 Recent studies confirmed that people unexposed to SARS-CoV-2 have preexisting reactivity, probably due to previous exposure to widely circulating common cold coronaviruses. Such preexistent reactivity against SARS-CoV-2 comes from memory T cells that can
A. Pasqui +5 more
core +1 more source
Investigating the immunomodulatory effects of SARS-CoV-2 proteins ORF3a, ORF6 and ORF9b on the inflammatory response of human lung epithelial cells [PDF]
, 2022 The COVID-19 pandemic has taken an unprecedented number of lives and brought incredibly high social costs across the globe. The disease severity is associated with a strong innate immune dysregulation characterised by low or inexistent levels of type I ...
Margarido Galán, Daniel
core
A putative new SARS-CoV protein, 3a*, encoded in an ORF overlapping ORF3a [PDF]
Journal of General Virology, 2020 ABSTRACTIdentification of the full complement of genes in SARS-CoV-2 is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be difficult to detect using conventional computational approaches, whereas high throughput experimental approaches – such as ribosome profiling – cannot ...
openaire +3 more sources
Biomolecules, 2022 Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu +3 more
doaj +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
F1000ResearchBackground Mutations in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enhance its pathogenicity by affecting its transmissibility, disease severity, and overall mortality in human populations.
Jin O-Uchi +10 more
doaj +1 more source
A next generation sequencing approach to elucidate CSSV species profiles [PDF]
, 2017 Cacao swollen shoot virus (CSSV) is a member of the family Caulimoviridae, genus Badnavirus and is naturally transmitted to Theobroma cacao by several mealybug species.
Abrokwah, Francis +5 more
core
Bidirectional interplay between SARS-CoV-2 and autophagy [PDF]
, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as the causative agent of the recent COVID-19 pandemic, continues representing one of the main health concerns worldwide.
Castro-Gonzalez, Sergio +2 more
core +1 more source