Results 51 to 60 of about 7,628 (191)

Spatial Transcriptomics and Single Cell-RNASeq Reveals Cellular Heterogeneity of SARS-CoV-2 in Lung Tissues and Global Mutational Patterns in COVID-19 Patients. [PDF]

J Med Virol
ABSTRACT RNA viruses have high mutation frequency, quick generation periods and vast population numbers, which promote fast evolution and host environment adaptation. We integrated scRNA‐seq and spatial transcriptomics to profile immune cells and viral gene expression in COVID‐19.
Hosseini ST, Mahmanzar M, Rahimian K, Bayat S, Gholamzad A, Sisakht MM, Farhadi A, Kuehu DL, Deng Y.   +8 more
europepmc   +2 more sources

Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2-host interactome [PDF]

, 2021
In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of interaction between host and SARS-CoV-2, determining the grade of COVID-19 severity, are still unknown.
Capobianchi, MR, Giombini, E, Ippolito, G, Lauria, FN, Locatelli, F, Maeurer, M, Messina, F, Montaldo, C, Sekaly, R-P, Sharma, AA, Zoccoli, A, Zumla, A   +11 more
core   +1 more source

A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence

Computational and Structural Biotechnology Journal, 2020
The genome of SARS-CoV-2, the coronavirus responsible for the Covid-19 pandemic, encodes a number of accessory genes. The longest accessory gene, Orf3a, plays important roles in the virus lifecycle indicated by experimental findings, known polymorphisms,
Christos A. Ouzounis
doaj   +1 more source

Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT [PDF]

, 2006
Severe acute respiratory syndrome coronavirus (SARS-CoV) 7a is an accessory protein with no known homologues. In this study, we report the interaction of a SARS-CoV 7a and small glutamine-rich tetratricopeptide repeat-containing protein (SGT).
Angeletti, Blatch, Bour, Burtram C. Fielding, Callahan, Chan, Chen, Chih-Fong Chou, Cziepluch, de Haan, Fielding, Haijema, Hirano, Ho, Ito, Keng, Klumperman, Liou, Manser, Marra, Nelson, Ontiveros, Ortego, Rota, Schantl, Sehaam Khan, Seng Gee Lim, Shen, Shuo Shen, Sikorski, Tan, Tan, Tan, Thompson, Timothy H.P. Tan, Vithiagaran Gunalan, Wang, Wang, Wanjin Hong, Winnefeld, Wu, Yee-Joo Tan   +41 more
core   +1 more source

Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells [PDF]

, 2006
The genome of the severe acute respiratory syndrome coronavirus encodes for eight accessory viral proteins with no known homologues in other coronaviruses.
Ameison, An, Barber, Benedict, Berger, Boya, Burtram C. Fielding, Chan, Chih-Fong Chou, Chong, Christian, Ding, Espinoza, Fouchier, Greenough, Guimarães, Guo, Hay, Hussain, Ito, Kuiken, Lang, Law, Los, Marra, Miller, Mori, Nelson, Peiris, Proskuryakov, Qin, Ran, Roberts, Roberts, Rota, Sehaam Khan, Seng Gee Lim, Shen, Shuo Shen, Snijder, Spector, Syntichaki, Syntichaki, Tan, Tan, Tan, Tan, Tan, Thomson, Timothy H.P. Tan, Wanjin Hong, Xu, Yan, Yee-Joo Tan, Yount, Yu, Yuan, Yuan, Zeng, Zhivotosky   +59 more
core   +1 more source

High-precision and cost-efficient sequencing for real-time COVID-19 surveillance. [PDF]

, 2021
COVID-19 global cases have climbed to more than 33 million, with over a million total deaths, as of September, 2020. Real-time massive SARS-CoV-2 whole genome sequencing is key to tracking chains of transmission and estimating the origin of disease ...
Emerson, Jane, Faraci, Gina, Lee, Ha, Park, Sung, Ward, Pamela   +4 more
core   +1 more source

Endomembrane Systems are Reorganized by ORF3a and Membrane (M) of SARS-CoV-2 [PDF]

SSRN Electronic Journal, 2020
SummaryThe endomembrane reticulum (ER) is largely reorganized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 ORF3a and membrane (M) protein expression affects ER-derived structures including cubic membrane and double membrane vesicles in coronavirus-infected cells; however, the molecular mechanisms underlying ER remodeling ...
Yun-Bin Lee, Minkyo Jung, Jeesoo Kim, Myeong-Gyun Kang, Chulhwan Kwak, Jong-Seo Kim, Ji-Young Mun, Hyun-Woo Rhee   +7 more
openaire   +1 more source

The role of JNK in the proinflammatory action of the SARS-CoV-2 protein ORF3a [PDF]

Medicinski Podmladak
Introduction: Coronavirus disease 2019 (COVID-19) is a contagious respiratory infection caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Aranđelović Lena, Mandić Miloš, Vučićević Ljubica, Misirkić Marjanović Maja, Trajković Vladimir   +4 more
doaj   +1 more source

Comparative in vivo analysis of recombinant type II feline coronaviruses with truncated and completed ORF3 region. [PDF]

, 2014
Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II ...
Belák, Sándor, Bálint, Ádám, Farsang, Attila, Zádori, Zoltán S.   +3 more
core   +2 more sources

Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein

Biomedicines, 2023
SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release, immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential ORF3a-induced apoptotic and inflammatory death mechanism, lung epithelial cells (A549)
Panagiotis Keramidas, Eleni Papachristou, Rigini M. Papi, Aglaia Mantsou, Theodora Choli-Papadopoulou   +4 more
doaj   +1 more source