Results 51 to 60 of about 6,597 (167)

Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples

Journal of Clinical and Translational Science, 2021
Background: SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium.
Han-Gang Yu, Gina Sizemore, Katy Smoot, Peter Perrotta   +3 more
doaj   +1 more source

A putative new SARS-CoV protein, 3a*, encoded in an ORF overlapping ORF3a [PDF]

Journal of General Virology, 2020
ABSTRACT Identification of the full complement of genes in SARS-CoV-2 is a crucial step towards gaining a fuller understanding of its molecular biology. However, short and/or overlapping genes can be difficult to detect using conventional computational approaches, whereas high throughput experimental approaches – such
openaire   +3 more sources

Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern. [PDF]

J Gen Virol
Infection with SARS-CoV-2 continues to be a threat to human health. Despite successful immunization campaigns, effective treatment of COVID-19 remains an essential need to help patients and prevent the spread of new virus strains. Viroporins are intracellular ion channels that are essential for virus replication and release, thus presenting promising ...
Breitinger U, Zakaria ZIS, Mahgoub HA, Wiessler AL, Tuerker E, Villmann C, Breitinger HG.   +6 more
europepmc   +4 more sources

Image3_A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport.TIF

, 2022
The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Bhargava Teja Sallapalli (14163438), Yanjin Zhang (318768), Shaolei Teng (422122), Ruth Cruz-Cosme (14163435), Vidhyanand Mahase (13789591), Jiantao Zhang (188731), Qiyi Tang (352533), Richard Y. Zhao (14163441), Dongxiao Liu (583846), Peixi Chang (4977464)   +9 more
core   +1 more source

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

mSystems, 2020
At the surge of the coronavirus disease 2019 (COVID-19) pandemic, we detected and identified six functional domains (I to VI) in the SARS-CoV-2 3a protein. Our analysis showed that the functional domains were linked to virulence, infectivity, ion channel formation, and virus release in SARS-CoV-2 3a. Our study also revealed the functional importance of
Issa, Elio, Merhi, Georgi, Panossian, Balig, Salloum, Tamara, Tokajian, Sima   +4 more
openaire   +5 more sources

Severe acute respiratory syndrome coronavirus Orf3a protein interacts with caveolin

Journal of General Virology, 2007
Theorf3a(also called X1 or U274) gene is the largest unique open reading frame in the severe acute respiratory syndrome coronavirus genome and has been proposed to encode a protein with three transmembrane domains and a large cytoplasmic domain. Recent work has suggested that the 3a protein may play a structural role in the viral life cycle, although ...
Hui, PY, Tanwar, C, Hussain, A, Jameel, S, Cheung, CY, Lee, MY, Peiris, JSM, Padhan, K   +7 more
openaire   +5 more sources

Image2_A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport.TIF

, 2022
The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Bhargava Teja Sallapalli (14163438), Yanjin Zhang (318768), Shaolei Teng (422122), Ruth Cruz-Cosme (14163435), Vidhyanand Mahase (13789591), Jiantao Zhang (188731), Qiyi Tang (352533), Richard Y. Zhao (14163441), Dongxiao Liu (583846), Peixi Chang (4977464)   +9 more
core   +1 more source

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10. [PDF]

Antiviral signaling, immune response and cell metabolism are dysregulated by SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic ...
Merino Herrán, Unai, Luque, Daniel, Mendoza-García, Laura, Lozano, Juan José, Megías, D, Fariñas Fernández, Marco, Mendoza-García, L, Cascante i Serratosa, Marta, Lozano, JJ, Fernández, MF, Fernández-Rodríguez, R, Villalba, JM, Garrido, Juan J., de Lucas-Rius, Ana, Herrán, UM, Fernández, Marco Fariñas, Calvo, C, Gómez, María Josefa Rodríguez, Grigas, Juozas, Thomson, Timothy M, Villalba, José Manuel, Cascante, Marta, Thomson, TM, López-Ayllón, Blanca D, Garrido, JJ, García-García, Tránsito, Foguet, Carles, Cascante, M, Redondo, Natalia, Megías, Diego, García-García, T, Herrán, Unai Merino, Calvet, A, Rodríguez, María Josefa, Marín Martínez, Silvia, Thomson, Timothy M., Garrido, Juan J, Farinas Fernández, Marcos, Montoya, María, Fernández-Rodríguez, Raúl, de Lucas-Rius, A, Luque, D, Montoya, M, Calvo, Cristina, López-Ayllón, Blanca D., Marin, S, Grigas, J, Marín, Silvia, Redondo, N, Lozano Salvatella, Juan José, López-Ayllón, BD, Luque Buzo, Daniel ; https://orcid.org/, Mandracchia, Biagio, Foguet, C, Mendoza, Laura, Mandracchia, B, Calvet, Alba, Lucas-Rius, Ana de, Rodríguez Gómez, María Josefa, Gómez, MJR   +59 more
core   +6 more sources

Image4_A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport.TIF

, 2022
The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet, everyone’s response to SARS-CoV-2 infection varies, and different viral variants confer diverse pathogenicity. Thus, it is imperative to understand how viral determinants
Bhargava Teja Sallapalli (14163438), Yanjin Zhang (318768), Shaolei Teng (422122), Ruth Cruz-Cosme (14163435), Vidhyanand Mahase (13789591), Jiantao Zhang (188731), Qiyi Tang (352533), Richard Y. Zhao (14163441), Dongxiao Liu (583846), Peixi Chang (4977464)   +9 more
core   +1 more source

Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins

Cell Reports, 2023
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.
Yun-Bin Lee, Minkyo Jung, Jeesoo Kim, Afandi Charles, Wanda Christ, Jiwoong Kang, Myeong-Gyun Kang, Chulhwan Kwak, Jonas Klingström, Anna Smed-Sörensen, Jong-Seo Kim, Ji Young Mun, Hyun-Woo Rhee   +12 more
doaj   +1 more source