Results 101 to 110 of about 7,628 (191)

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, Volume 35, Issue 51, December 16, 2025.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

“Fertile” Mutations in SARS‐CoV‐2 RNA More Frequently Occurred in Hairpin Loops That Determine Virus Evolution

APMIS, Volume 133, Issue 12, December 2025.
ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson, Pierre Pontarotti, Jacques Fantini, Anthony Levasseur, Christian Devaux, Didier Raoult   +5 more
wiley   +1 more source

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and
Chia-Ming Su, Leyi Wang, Dongwan Yoo
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes

BMC Infectious Diseases, 2023
Background The corona virus SARS-CoV-2 is the causative agent of recent most global pandemic. Its genome encodes various proteins categorized as non-structural, accessory, and structural proteins.
Rabia Nawaz, Muhammad Ali Arif, Zainab Ahmad, Ammara Ahad, Muhammad Shahid, Zohal Hassan, Ali Husnain, Ali Aslam, Muhammad Saad Raza, Uqba Mehmood, Muhammad Idrees   +10 more
doaj   +1 more source

Cucurbit aphid‐borne yellows virus: A growing but overlooked threat to global cucurbit production

Annals of Applied Biology, Volume 187, Issue 3, Page 318-329, November 2025.
Cucurbit aphid‐borne yellows virus (CABYV) presents a significant threat to cucurbit crops worldwide. In this description of a plant virus we review what is currently known about this plant virus. Abstract Cucurbit aphid‐borne yellows virus (CABYV) presents a significant threat to cucurbit crops worldwide.
M. P. Rabadán, Véronique Brault, Veronica Truniger   +2 more
wiley   +1 more source

Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.

PLoS ONE, 2021
COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic.
Manna Zhang, Lin Li, Ma Luo, Binhua Liang   +3 more
doaj   +1 more source

Global analysis of more than 50,000 SARS-Cov-2 genomes reveals epistasis between 8 viral genes

, 2020
Genome-wide epistasis analysis is a powerful tool to infer gene interactions, which can guide drug and vaccine development and lead to a deeper understanding of microbial pathogenesis.
Aurell, Erik, Dichio, Vito, Horta, Edwin Rodríguez, Thorell, Kaisa, Zeng, Hong-Li   +4 more
core   +1 more source

Exploring The Interactions Between SARS-CoV-2 and Host Proteins. [PDF]

, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current pandemic, Coronavirus Disease 2019 (COVID-19).
Shrestha, Sojan
core   +1 more source

Studying the immunomodulatory effects of SARS-CoV-2 viral proteins in human lung epithelial cell lines [PDF]

, 2021
The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents a wide spectrum of clinical manifestations which range from asymptomatic or cold-like symptoms to severe pneumonia and ...
Dürkoop, Mirjam
core