Results 101 to 110 of about 6,314 (165)

Supplementary materials for manuscript "SARS-CoV-2-ORF3a variant Q57H reduces its pro-apoptotic activity in host cells"

, 2023
Original Western blotting images for the manuscript "SARS-CoV-2-ORF3a variant Q57H reduces its pro-apoptotic activity in host cells".
Iuliia Polina (8636695), Bridget Nieto (17629434), Isabel Chaput (17629431), Jin O-Uchi (11560216), Michael Cypress (17629430), Maria Landherr (17629418), Bong Sook Jhun (13141923)   +6 more
core   +1 more source

SARS-CoV-2 ORF3a impairs mRNA nuclear export to facilitate immune evasion [PDF]

Viruses employ diverse strategies to suppress host gene expression and immune re-sponses to facilitate their replication. One common strategy is the inhibition of host mRNA nuclear export.
Xiang, Chengyu
core  

Super-resolution imaging of aquaporin-4, Kir4.1 and ORF3a in the plasma membrane of rat astrocytes

, 2022
Delovanje astrocitov je ključnega pomena za uravnavanje vodne in ionske homeostaze v centralnega živčnega sistema (CŽS). V astrocitih igrajo pri teh procesih vodilno vlogo kalijevi kanalčki iz družine Kir (Kir4.1) in akvaporini tipa 4 (AQP4). Domneva se,
Rupnik, Marko
core  

Sequence analysis of ORF3a and flanking regions.

, 2015
Pseudo-alignment of representative luteovirus and polerovirus NCBI species RefSeqs (GenBank accession numbers indicated at left) for ORF3a and flanking regions. Spaces separate codons in the ORF3a reading frame.
Aurélie M. Rakotondrafara (735603), Danièle Scheidecker (735601), Véronique Ziegler-Graff (545603), Véronique Brault (160595), W. Allen Miller (172494), Ekaterina Smirnova (30901), Betty Y.-W. Chung (486028), Andrew E. Firth (122998), Catherine Reinbold (735602)   +8 more
core   +1 more source

A live attenuated SARS-CoV-2 vaccine constructed by dual inactivation of NSP16 and ORF3a. [PDF]

EBioMedicine
Live attenuated vaccines against SARS-CoV-2 activate all phases of host immunity resembling a natural infection and they block viral transmission more efficiently than existing vaccines in human use. In our prior work, we characterised an attenuated SARS-CoV-2 variant, designated d16, which harbours a D130A mutation in the NSP16 protein, inactivating ...
Ye ZW, Ong CP, Cao H, Tang K, Gray VS, Hinson Cheung PH, Wang J, Li W, Zhang H, Luo P, Ni T, Chan CP, Zhang M, Zhang Y, Ling GS, Yuan S, Jin DY.   +16 more
europepmc   +3 more sources

Identification and Characterization of a Unique Ribosomal Frameshifting Signal in SARS-CoV ORF3A [PDF]

, 2006
Wang, Xiao X., Liao, Ying, Wong, Sek M., Liu, Ding X.   +3 more
openaire   +2 more sources

COVID-19 IgM and PCR CT values of ORF3a and N gene.

COVID-19 IgM and PCR CT values of ORF3a and N gene.
Issabella Asamoah (17941272), Allen Steele-Dadzie (17941281), Kwamena W. C. Sagoe (17334446), Albert Turkson (17941287), Quaneeta Mohktar (17563371), Bright Adu (133241), Atta Senior Kuffour (17941284), Kantanka Addo-Osafo (3498869), Priscilla Vandyck-Sey (17941278), Yaw A. Afrane (8491401), Mildred Adusei-Poku (17941275), Ivy Asantewaa Asante (13783364)   +11 more
core   +1 more source

Expression of SARS-CoV-2-ORF3a protein induces cardiomyocyte damage

Biophysical Journal, 2022
Polina, Iuliia A., Guo, Yugene, Cypress, Michael W., Tolkacheva, Elena G., Sook Jhun, Bong, O-Uchi, Jin   +5 more
openaire   +2 more sources

ORF3a is a key driver of maternal SARS-CoV-2 infection-associated placental dysfunction

Abstract SARS-CoV-2 infection during pregnancy is associated with an increased risk of pre-eclampsia (PE), a hypertensive disorder, but the molecular mechanisms remain poorly understood. Here, we identify ORF3a, a SARS-CoV-2 accessory protein, as a key factor in placental dysfunction, driving autophagy dysregulation, trophoblast maturation ...
Indira Mysorekar, Deepak Kumar, Eliza McColl, Rowan Karvas, Brittany Jones, Long Tran, Emily Diveley, Sukanta Jash, Surendra Sharma, Jeannie Kelly, Thorold Theunissen   +10 more
openaire   +2 more sources

SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism. [PDF]

Cell Rep
Goodson BA, Montenegro Vazquez V, Doyle A, Kolaczkowski OM, Liu R, Jia J, Ishida M, Ye C, Kell AM, Bradfute SB, Rosas Lemus M, Wang H, Han X, Pu J.   +13 more
europepmc   +1 more source