Results 111 to 120 of about 7,628 (191)

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

The SARS coronavirus accessory protein ORF3a rescues potassium conductance in yeast.

microPublication biology
ORF3a is an accessory protein expressed by all human pathogen coronaviruses and is the only accessory protein that strongly affects viral fitness. Its deletion reduces severity in both alpha- and beta-coronaviruses, demonstrating a conserved function across the superfamily.
Rosenbaum, Joel C., Carlson, Anne E.
openaire   +2 more sources

Structural bioinformatics analysis of the SARS-COV-2 proteome evolution to characterize the emerging variants of the virus and to suggest possible therapeutic strategies [PDF]

, 2022
SARS-CoV-2 is a new coronavirus responsible for the global COVID-19 pandemic, detected in China in December 2019 and that has spread rapidly across the world. Our unit, with its specific expertise in structural bioinformatics and molecular modelling, has
BIANCHI, MARTINA
core  

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells [PDF]

Cellular & Molecular Immunology, 2020
Ren, Yujie, Shu, Ting, Wu, Di, Mu, Jingfang, Wang, Chong, Huang, Muhan, Han, Yang, Zhang, Xue-Yi, Zhou, Wei, Qiu, Yang, Zhou, Xi   +10 more
openaire   +2 more sources

Novel Mechanism of the L‐Type Voltage‐Gated Channels/Calpains Axis in Influenza A Virus‐Induced Autophagosome Activity

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
Hannah Murphy, Hinh Ly
wiley   +1 more source

SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects

Pathogens
The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health complications.
Jiantao Zhang, Kellie Hom, Chenyu Zhang, Mohamed Nasr, Volodymyr Gerzanich, Yanjin Zhang, Qiyi Tang, Fengtian Xue, J. Marc Simard, Richard Y. Zhao   +9 more
doaj   +1 more source

Skrining Senyawa dari Tanaman Rhodomyrtus tomentosa (Aiton) Hassk terhadap SARS-CoV-2 ORF3a

Jurnal Surya Medika, 2021
The ORF3a protein from SARS-CoV has functions in terms of ion channel activity, modulates the trafficking properties of SARS-CoV spike (S) protein, increases fibrinogen expression in pulmonary epithelial cells, and induces apoptosis. So that research is needed to overcome the ORF3a experiment.
openaire   +2 more sources

Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: Engineering a recombination-resistant genome [PDF]

, 2006
Live virus vaccines provide significant protection against many detrimental human and animal diseases, but reversion to virulence by mutation and recombination has reduced appeal.
B. Yount, R. S. Roberts, L. Lindesmith, R. S. Baric, Kew, Seligman, Poon, Wang, Yount, Sawicki, Schaad, Zuniga, Sola, Sims, Keck, Smati, Thiry, Cheng, Figlerowicz, Nagy, Nagy, Goebel, Goebel, Wertz, Curtis, Kuo, de Haan, Vennema, Almazan, Yount, Denison, Snijder, Bacher, Escors, Yount   +34 more
core   +2 more sources

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 [PDF]

Antiviral signaling, immune response and cell metabolism are dysregulated by SARS-CoV-2, the causative agent of COVID-19. Here, we show that SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 induce a significant mitochondrial and metabolic ...
Calvet, A, Calvo, C, Cascante, M, de Lucas-Rius, A, Fernández, MF, Fernández-Rodríguez, R, Foguet, C, García-García, T, Garrido, JJ, Grigas, J, Gómez, MJR, Herrán, UM, Lozano, JJ, Luque Buzo, Daniel , Luque, D, López-Ayllón, BD, Mandracchia, B, Marin, S, Megías, D, Mendoza-García, L, Montoya, M, Redondo, N, Thomson, TM, Villalba, JM   +23 more
core   +3 more sources

Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a

The Microbe
The COVID-19 pandemic caused by SARS-CoV-2 remains an ongoing global health concern. Understanding the roles of SARS-CoV-2 accessory proteins is essential for developing effective therapeutic strategies.
Apoorva, Astha Shukla, Atul Kumar, Saurabh Singh, Sunit K. Singh   +4 more
doaj   +1 more source