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Is Autophagy a Friend or Foe in SARS-CoV-2 Infection? [PDF]

Viruses
Khan A, Ling J, Li J.
europepmc   +1 more source

Heterogeneous Evolution Among SARS-CoV-2 Genes and Variants of Concern. [PDF]

J Med Virol
González-Vázquez LD, Iglesias-Rivas P, Ferreiro D, Arenas M.   +3 more
europepmc   +1 more source

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HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling.

Science Signaling
Activation of the stimulator of interferon genes (STING) pathway by cytosolic DNA leads to the activation of the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB).
Yajuan Rui, Si Shen, Yanpu Wang, Leyi Cheng, Shiqi Chen, Ying Hu, Yong Cai, Wei Wei, Jiaming Su, Xiao-Fang Yu   +9 more
semanticscholar   +1 more source

ORF3a is a key driver of maternal SARS-CoV-2 infection-associated placental dysfunction

Research Square
SARS-CoV-2 infection during pregnancy is associated with an increased risk of pre-eclampsia (PE), a hypertensive disorder, but the molecular mechanisms remain poorly understood.
I. Mysorekar, Deepak Kumar, Eliza R. McColl, R. Karvas, Brittany R. Jones, Long B Tran, Emily Diveley, Sukanta Jash, Surendra Sharma, Jeannie C. Kelly, Thorold Theunissen   +10 more
semanticscholar   +1 more source

Genetic variety of ORF3a shapes SARS‐CoV‐2 fitness through modulation of lipid droplet

Journal of Medical Virology, 2023
Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection leads to the accumulation of lipid droplets (LD), the central hubs of the lipid metabolism, in vitro or in type II pneumocytes and monocytes from coronavirus disease 19 (COVID‐19 ...
Weili Wang, Yafei Qu, Xin Wang, Maggie Z. X. Xiao, Joyce Fu, Lei Chen, Yuejuan Zheng, Q. Liang   +7 more
semanticscholar   +1 more source

Regulation of autophagy by SARS‐CoV‐2: The multifunctional contributions of ORF3a

Journal of Medical Virology, 2023
Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) regulates autophagic flux by blocking the fusion of autophagosomes with lysosomes, causing the accumulation of membranous vesicles for replication.
Mohd Shariq, Asrar A. Malik, J. A. Sheikh, S. Hasnain, N. Ehtesham   +4 more
semanticscholar   +1 more source

ASC Dynamics Associated with ORF3a Protein Expression in Microvascular Lung Endothelial Cells

Proceedings of the Bulgarian Academy of Sciences
The NLRP3 inflammasome is a key sensor of cellular stress and pathogen-associated signals in the innate immune system. Using confocal fluorescence microscopy in microvascular lung endothelial cells, we examined ASC speck formation following expression of
Yuliia Mariienko, Diana Pendicheva, S. Hayrabedyan, K. Todorova   +3 more
semanticscholar   +1 more source

Explore Covid-19 virus bulk sequences from MN908947/ NC_045512, MU to Omicron LP.8 and NB.1.8.1 series ORF3a image for rapid detection and analysis

2025 Second International Conference on Artificial Intelligence for Medicine, Health and Care (AIxMHC)
Since the outbreak of Covid-19 caused by the SARS-CoV-2 virus in 2019 until now, from GenBank ID: MN908947 / GenBank ID: NC_045512 to the current prevalent LP.8 and NB.1.8 lineages derived from the Omicron (B.1.1.529) variant, most people have relied on ...
Tzung-Wei Wang, Ming-Kuang Li, Der-Chyuan Lou, Chun‐Yuan Lin   +3 more
semanticscholar   +1 more source

ORF3a of SARS-CoV-2 modulates PI3K/AKT signaling in human lung epithelial cells via hsa-miR-155-5p.

International Journal of Biological Macromolecules
SARS-CoV-2 infection results in cytokine burst, leading to proinflammatory responses in lungs of COVID-19 patients. SARS-CoV-2 ORF3a triggers the generation of proinflammatory cytokines.
Faiyaz Ahmad, Vishal Keshri, S. K. Singh
semanticscholar   +1 more source