Results 71 to 80 of about 4,200 (198)
Viral Membrane Channels: Role and Function in the Virus Life Cycle
Viruses, 2015 Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral ...
ChingWooen Sze, Yee-Joo Tan
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Viruses, 2022 The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a monomer and a pentameric ion channel.
Isobel Webb +8 more
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Characterization of the SARS‐CoV‐2 E Protein: Sequence, Structure, Viroporin, and Inhibitors
Protein Science, 2021 The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding the impact of coronaviruses (CoVs) on host cells is very important for disease treatment.
Yipeng Cao +6 more
semanticscholar +1 more source
Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]
FEBS Letters, 2003 Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L. +3 more
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Physiological Reports, 2021 Discovering therapeutics for COVID‐19 is a priority. Besides high‐throughput screening of compounds, candidates might be identified based on their known mechanisms of action and current understanding of the SARs‐CoV‐2 life cycle.
Kirk P. Conrad
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, 2022 Using bioinformatic approaches, we present evidence of distant relatedness among the Ephemerovirus Viroporin family, the Rhabdoviridae Putative Viroporin U5 family, the Phospholemman family, and the Small Integral Membrane Protein family. Our approach is
Tyler D. (12076325) +3 more
core +1 more source
Viroporins: Structures and functions beyond cell membrane permeabilization [PDF]
Viruses, 2015 Viroporins represent an interesting group of viral proteins that exhibit two sets of functions. First, they participate in several viral processes that are necessary for efficient production of virus progeny. [...]
José Nieva, Luis Carrasco
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Targeting the Channel Activity of Viroporins
, 2016 Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the ...
To, Janet, Surya, Wahyu, Torres, Jaume
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Molecules, 2020 The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an ...
Maggie C. Duncan +12 more
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Calicivirus Non-structural Proteins: Potential Functions in Replication and Host Cell Manipulation
Frontiers in Microbiology, 2021 The Caliciviridae are a family of viruses with a single-stranded, non-segmented RNA genome of positive polarity. The ongoing discovery of caliciviruses has increased the number of genera in this family to 11 (Norovirus, Nebovirus, Sapovirus, Lagovirus ...
Elena Smertina +8 more
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