Results 71 to 80 of about 4,749 (194)

Mechanisms of membrane permeabilization by picornavirus 2B viroporin [PDF]

FEBS Letters, 2003
Cell infection by picornaviruses leads to membrane permeabilization. Recent evidence suggests the involvement of the non‐structural protein 2B in this process. We have recently reported the detection of 2B porin‐like activity in isolated membrane–protein systems that lack other cell components. According to data derived from these model membranes, four
Nieva, José L., Agirre, Aitziber, Nir, Shlomo, Carrasco, Luis   +3 more
openaire   +2 more sources

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

PLoS Pathogens, 2012
Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito, Yusuke Yanagi, Takeshi Ichinohe   +2 more
openaire   +4 more sources

Membrane-Active Peptides Derived from Picornavirus 2B Viroporin

Current Protein & Peptide Science, 2012
Viruses have evolved membrane-restructuring mechanisms for sustaining entry into cells, genome replication and release from host cells. Picornavirus 2B, a non-structural protein required for effective viral replication, functions as a potent intracellular pore-forming toxin by altering the permeability of cellular endomembranes.
Sánchez-Martínez, Silvia, Madan, Vanesa, Carrasco Llamas, Luis, Nieva, José Luis   +3 more
openaire   +3 more sources

Lagovirus Non-structural Protein p23: A Putative Viroporin That Interacts With Heat Shock Proteins and Uses a Disulfide Bond for Dimerization

Frontiers in Microbiology, 2022
The exact function(s) of the lagovirus non-structural protein p23 is unknown as robust cell culture systems for the Rabbit haemorrhagic disease virus (RHDV) and other lagoviruses have not been established.
Elena Smertina, Elena Smertina, Elena Smertina, Adam J. Carroll, Joseph Boileau, Edward Emmott, Maria Jenckel, Harpreet Vohra, Vivien Rolland, Philip Hands, Junna Hayashi, Matthew J. Neave, Jian-Wei Liu, Robyn N. Hall, Robyn N. Hall, Tanja Strive, Tanja Strive, Michael Frese, Michael Frese   +18 more
doaj   +1 more source

Modulation of potassium channels inhibits bunyavirus infection [PDF]

, 2015
Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity.
Adams, Bagal, Barr, Barry, Baxter, Becchetti, Bowen, Bridgen, Briese, Briese, Bräuner, Buchholz, Carlton-Smith, Carvalho, Cheng, Crotty, Davis, Dong, Dowall, Dwivedi, Eleftherianos, Elliott, Elliott, Elliott, Enyedi, Evangelista, Feron, Feske, Fontana, Frugulhetti, Goldstein, Goldstein, Goller, Hoffmann, Hollidge, Hsu, Hu, Igloi, Irvine, Jiang, Kaakkola, Kainulainen, Kohl, Kudo, Lang, Lesage, Maltezou, Mankouri, Mankouri, Mathie, Meier, Miller, Murphy, Musset, Nieva, Novoa, Peluffo, Sakurai, Sanchez, Schoen, Shi, Shin, Shtanko, Tauro, Walter, Weber, Wicher, Windley, Wu, Zhang, Zhang   +70 more
core   +4 more sources

Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

Frontiers in Microbiology, 2020
Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. The recently characterized E protein ion channel activity (EIC) has also been implicated in modulating viral pathogenesis.
Shumin Li, Lixia Yuan, Guo Dai, Rui Ai Chen, Rui Ai Chen, Ding Xiang Liu, To Sing Fung   +6 more
doaj   +1 more source

Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system [PDF]

, 2018
Indexación: Scopus.This work was supported by Comisión Nacional de Investigación Científica y Tecnolígica (CONICYT) N◦21151028 and FONDECYT (N◦1070352 and N◦1170964) and the Millennium Institute on Immunology and Immunotherapy (P09/016-F).Human ...
Benavente, F.M., Bueno, S.M., Gonzalez, P.A., Gálvez, N.M.S., Kalergis, A.M., Lay, M.K., Pizarro-Ortega, M.S., Riedel, C., Soto, J.A.   +8 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

Frontiers in Microbiology, 2019
Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate
I-Yin Chen, Miyu Moriyama, Ming-Fu Chang, Takeshi Ichinohe   +3 more
doaj   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source