Results 91 to 100 of about 3,182 (158)

The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins

Frontiers in Microbiology, 2020
Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of ...
Jindai Fan, Jindai Fan, Jindai Fan, Mengru Zhang, Mengru Zhang, Mengru Zhang, Chenchen Liu, Chenchen Liu, Chenchen Liu, Mengjiao Zhu, Mengjiao Zhu, Mengjiao Zhu, Zilin Zhang, Zilin Zhang, Zilin Zhang, Keke Wu, Keke Wu, Keke Wu, Zhaoyao Li, Zhaoyao Li, Zhaoyao Li, Wenhui Li, Wenhui Li, Wenhui Li, Shuangqi Fan, Shuangqi Fan, Shuangqi Fan, Chunmei Ju, Chunmei Ju, Chunmei Ju, Lin Yi, Lin Yi, Lin Yi, Hongxing Ding, Hongxing Ding, Hongxing Ding, Mingqiu Zhao, Mingqiu Zhao, Mingqiu Zhao, Jinding Chen, Jinding Chen, Jinding Chen   +41 more
doaj   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

PLoS Pathogens, 2012
Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito, Yusuke Yanagi, Takeshi Ichinohe   +2 more
openaire   +4 more sources

Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

eLife
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes ...
Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin   +16 more
doaj   +1 more source

Viroporin Activity of the Foot-and-Mouth Disease Virus Non-Structural 2B Protein.

PLoS ONE, 2015
Viroporins are a family of low-molecular-weight hydrophobic transmembrane proteins that are encoded by various animal viruses. Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing ...
Da Ao, Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, To Sing Fung, Yan-Quan Wei, Shi-Chong Han, Xue-Ping Yao, Sui-Zhong Cao, Ding Xiang Liu, Xiang-Tao Liu   +10 more
doaj   +1 more source

Investigation of Molecular Mechanism of JC virus Viroporin Activity

Uirusu, 2015
Viroporins are small and hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the permeability of cellular membranes and the production of progeny virus particles. JC virus (JCV) is the causative agent of progressive multifocal leukoenchephalopathy (PML).
openaire   +3 more sources

Coupling neutron reflectivity with cell-free protein synthesis to probe membrane protein structure in supported bilayers

Scientific Reports, 2017
The structure of the p7 viroporin, an oligomeric membrane protein ion channel involved in the assembly and release of the hepatitis C virus, was determined from proteins expressed and inserted directly into supported model lipid membranes using cell-free
Thomas Soranzo, Donald K. Martin, Jean-Luc Lenormand, Erik B. Watkins   +3 more
doaj   +1 more source

Viroporin-mediated Membrane Permeabilization [PDF]

Journal of Biological Chemistry, 2002
Aitziber Agirre, Angel Barco, Luis Carrasco, José L. Nieva   +3 more
openaire   +1 more source

Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization

Quarterly Reviews of Biophysics
Abstract The ‘Viroporin’ family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence and structural diversity, viroporins share a common functional trend: their capacity to assemble transmembrane channels during the replication cycle of the virus.
Antonio Alcaraz, José L. Nieva
openaire   +3 more sources

Computational electrophysiology simulation study of the Dengue virus viroporins

Journal of Biomolecular Structure and Dynamics
Dengue virus, an arbovirus belongs to the Flavivirus genus is the causative agent of Dengue fever, Dengue Hemorrhagic fever and Dengue Shock Syndrome, and accounts for thousands of lives every year. Here, we have characterized three such Dengue virus proteins (NS2A, NS2B and M) which have been previously shown to possess porin like functions.
Dwaipayan Chaudhuri, Satyabrata Majumder, Kalyan Giri   +2 more
openaire   +2 more sources