Results 81 to 90 of about 3,182 (158)

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

PLoS Pathogens, 2010
Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group of proteins that interact with plasma membranes modifying permeability and can promote the release of viral particles.
Suzuki, Tadaki, Orba, Yasuko, Okada, Yuki, Sunden, Yuji, Kimura, Takashi, Tanaka, Shinya, Nagashima, Kazuo, Hall, William W., Sawa, Hirofumi   +8 more
openaire   +5 more sources

The Interplay Between Viral Infection and Cell Death: A Ping‐Pong Effect

Advances in Virology, Volume 2025, Issue 1, 2025.
Programmed cell death (PCD) is a well‐studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival.
Alireza Nourazarian, Hadi Yousefi, Cigir Biray Avci, Behrouz Shademan, Emad Behboudi, Ahmed Majeed Al-Shammari   +5 more
wiley   +1 more source

The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection

Viruses, 2015
Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung, Jaume Torres, Ding Xiang Liu   +2 more
doaj   +1 more source

Mouse polyomavirus infection induces lamin reorganisation

The FEBS Journal, Volume 291, Issue 23, Page 5133-5155, December 2024.
Here, we investigated the roles of lamins as important nuclear proteins in the replication cycle of the mouse polyomavirus. We detected accumulation of the major capsid protein VP1 under the nuclear lamina, defects in nuclear lamina staining and different lamin A/C phosphorylation patterns following viral infection.
Kateřina Bruštíková, Boris Ryabchenko, Sandra Žáčková, Vojtěch Šroller, Jitka Forstová, Lenka Horníková   +5 more
wiley   +1 more source

Targeting Endoplasmic Reticulum and/or Mitochondrial Ca2+ Fluxes as Therapeutic Strategy for HCV Infection

Frontiers in Chemistry, 2018
Chronic hepatitis C is characterized by metabolic disorders and by a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that can in the long term lead to liver cirrhosis and hepatocellular carcinoma ...
Rosella Scrima, Claudia Piccoli, Darius Moradpour, Nazzareno Capitanio   +3 more
doaj   +1 more source

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam, Vinod R. M. T. Balasubramaniam   +1 more
wiley   +1 more source

Viroporins and inflammasomes: A key to understand virus-induced inflammation

The International Journal of Biochemistry & Cell Biology, 2020
Viroporins are virus encoded proteins that alter membrane permeability and can trigger subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a hydrophilic pore which facilitates ion transport across host cell membranes.
Farag, N.S., Breitinger, U., Breitinger, H.G., El Azizi, M.A.   +3 more
openaire   +2 more sources

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

Long‐term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged.
Laetitia Gay, Valérie Desquiret‐Dumas, Nicolas Nagot, Clara Rapenne, Philippe Van de Perre, Pascal Reynier, Jean‐Pierre Molès   +6 more
wiley   +1 more source

Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum

Viruses, 2018
We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical
Douglas P. Gladue, Eneko Largo, Lauren G. Holinka, Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Keith A. Berggren, Guillermo R. Risatti, Jose L. Nieva, Manuel V. Borca   +8 more
doaj   +1 more source