Results 81 to 90 of about 4,749 (194)
Zika M—A Potential Viroporin: Mutational Study and Drug Repurposing
Biomedicines, 2022 Genus Flavivirus contains several important human pathogens. Among these, the Zika virus is an emerging etiological agent that merits concern. One of its structural proteins, prM, plays an essential role in viral maturation and assembly, making it an attractive drug and vaccine development target.
Prabhat Pratap Singh Tomar +3 more
openaire +3 more sources
Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus [PDF]
, 2018 Respiratory syncytial virus (RSV) and influenza are among the most important causes of severe respiratory disease worldwide. Despite the clinical need, barriers to developing reliably effective vaccines against these viruses have remained firmly in place
Ascough, SC, Chiu, C, Paterson, S
core +2 more sources
Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak +3 more
wiley +1 more source
Targeting the Channel Activity of Viroporins
, 2016 Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the ...
To, Janet, Surya, Wahyu, Torres, Jaume
openaire +2 more sources
Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV
Viruses, 2016 The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The transmembrane domain of the protein has dual functions: it counteracts the human restriction factor ...
Timo Greiner +7 more
doaj +1 more source
ICTV Virus Taxonomy Profile: Rhabdoviridae. [PDF]
, 2018 This is the final version of the article. Available from the publisher via the DOI in this record.The family Rhabdoviridae comprises viruses with negative-sense (-) single-stranded RNA genomes of 10.8-16.1 kb.
Blasdell, KR +12 more
core +1 more source
Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
Journal of Inflammation Research, 2021 SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture ...
Choudhury SM, Ma X, Abdullah SW, Zheng H
doaj
Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases [PDF]
, 2016 Foot-and-mouth disease virus (FMDV) causes economically-damaging infections of cloven-hooved animals, with outbreaks resulting in large financial losses to the agricultural industry.
Belsham +9 more
core +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel
The FEBS Journal, Volume 292, Issue 13, Page 3378-3396, July 2025.A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang +5 more
wiley +1 more source