Results 101 to 110 of about 4,749 (194)

Mouse polyomavirus infection induces lamin reorganisation

The FEBS Journal, Volume 291, Issue 23, Page 5133-5155, December 2024.
Here, we investigated the roles of lamins as important nuclear proteins in the replication cycle of the mouse polyomavirus. We detected accumulation of the major capsid protein VP1 under the nuclear lamina, defects in nuclear lamina staining and different lamin A/C phosphorylation patterns following viral infection.
Kateřina Bruštíková, Boris Ryabchenko, Sandra Žáčková, Vojtěch Šroller, Jitka Forstová, Lenka Horníková   +5 more
wiley   +1 more source

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

Viruses, 2015
Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle, Samuel John Dobson, Marietta Müller, Andrew Macdonald   +3 more
doaj   +1 more source

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

Influenza and Other Respiratory Viruses, Volume 18, Issue 12, December 2024.
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was underestimated due to limited data and serotyping methods. In 2014, the United States experienced outbreaks of acute flaccid myelitis (AFM) in children EV‐D68 positive.
Nida Kalam, Vinod R. M. T. Balasubramaniam   +1 more
wiley   +1 more source

Impact of histidine residues on the transmembrane helices of viroporins [PDF]

Molecular Membrane Biology, 2013
Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan, Park, Sang Ho, Tian, Ye, Opella, Stanley J   +3 more
openaire   +4 more sources

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection

Viruses, 2015
Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung, Jaume Torres, Ding Xiang Liu   +2 more
doaj   +1 more source

Long‐term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged.
Laetitia Gay, Valérie Desquiret‐Dumas, Nicolas Nagot, Clara Rapenne, Philippe Van de Perre, Pascal Reynier, Jean‐Pierre Molès   +6 more
wiley   +1 more source

Targeting Endoplasmic Reticulum and/or Mitochondrial Ca2+ Fluxes as Therapeutic Strategy for HCV Infection

Frontiers in Chemistry, 2018
Chronic hepatitis C is characterized by metabolic disorders and by a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that can in the long term lead to liver cirrhosis and hepatocellular carcinoma ...
Rosella Scrima, Claudia Piccoli, Darius Moradpour, Nazzareno Capitanio   +3 more
doaj   +1 more source

The Encephalomyocarditis Virus [PDF]

, 2012
The encephalomyocarditis virus (EMCV) is a small non-enveloped single-strand RNA virus, the causative agent of not only myocarditis and encephalitis, but also neurological diseases, reproductive disorders and diabetes in many mammalian species.
Bakkali-Kassimi, Labib, Carocci, Margot
core   +2 more sources

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source