Results 101 to 110 of about 4,200 (198)

Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]

DNA and Cell Biology, 2013
Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire   +2 more sources

SARS-CoV-2 infection alkalinizes the ERGIC and lysosomes through the viroporin activity of the viral envelope protein

bioRxiv, 2022
The coronavirus SARS-CoV-2, the agent of the deadly COVID-19 pandemic, is an enveloped virus propagating within the endocytic and secretory organelles of host mammalian cells.
Wen-An Wang, Amado Carreras-Sureda, N. Demaurex   +2 more
semanticscholar   +1 more source

The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola, Md Majharul Islam, Elaheh Hadadianpour, Peter P. Borbat, Adeyemi Ogunbowale, Juan C. R. Amador, Elka R. Georgieva   +6 more
wiley   +1 more source

Expression and purification of MERS-CoV envelope protein, an essential viroporin, using the baculovirus expression system

Iranian Journal of Microbiology, 2023
Background and Objectives: The causative agent of Middle East Respiratory Syndrome (MERS) is a zoonotic Coronavirus (MERS-CoV) identified in Saudi Arabia in 2012. The envelope (E) protein of MERS-CoV is a small viral protein which plays several essential
Entedar A. J. Alsaadi, D. Alghezi, I. Jones   +2 more
semanticscholar   +1 more source

Assessing the Impact of Colchicine on Pulmonary Fibrosis Using Imaging in Patients With Moderate‐to‐Severe COVID‐19 Pneumonia

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak, Mustafa Ilteris Bardakci, Ugur Temel, Karuna Sharma   +3 more
wiley   +1 more source

Porcine Rotavirus NSP4 Inhibits Type I Interferon Production via NRBF2‐Mediated Autophagic Degradation of MDA‐5

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The type I interferon (IFN‐I) signaling pathway plays a pivotal role in orchestrating antiviral innate immune defenses, particularly during the clearance of invading pathogens. Rotaviruses have evolved a repertoire of viral proteins to counteract host immune surveillance. While certain functions of rotavirus nonstructural proteins in antagonizing IFN‐I
Jiaxing Zhan, Tianhao Liang, Jiale Chen, Jingying Wang, Enqi Dai, Ting Wang, Shaojie Wang, Zixuan Cao, Hanwei Jiao, Yan Zeng, Chunfeng Wang, Xin Cao, Linzhu Ren   +12 more
wiley   +1 more source

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

Viruses
The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated ...
Edward B. Stephens, Dusan Kunec, Wyatt Henke, Ricardo Martin Vidal, Brandon Greishaber, Rabina Saud, Maria Kalamvoki, Gagandeep Singh, Sujan Kafle, Jessie D. Trujillo, Franco Matias Ferreyra, Igor Morozov, Juergen A. Richt   +12 more
doaj   +1 more source

Celastrol Suppresses Porcine Deltacoronavirus Replication by Modulating Endoplasmic Reticulum Stress‐Associated Ca2+ Balance

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine deltacoronavirus (PDCoV) infection causes watery diarrhea and even death in neonatal piglets, leading to substantial economic losses. Meanwhile, emerging evidence indicates the potential risk of PDCoV to threaten human health and public safety. However, the effective vaccines or medicines are deficient.
Jialu Zhang, Yuqian Liu, Letao Gao, Wenzhe Liu, Ru Yan, Die Zhu, Zhouyuan Wang, Lianci Peng, Rendong Fang, Tingting Chen, Bin Li   +10 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

Viruses, 2015
Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses.
Jamie Royle, Samuel John Dobson, Marietta Müller, Andrew Macdonald   +3 more
doaj   +1 more source