Results 121 to 130 of about 4,200 (198)
Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity. [PDF]
VirusesViruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins that, upon oligomerization, exhibit ion channel properties with mild ion selectivity.
Cedillo-Barrón L +3 more
europepmc +4 more sources
Viruses, 2018 We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical
Douglas P. Gladue +8 more
doaj +1 more source
Biochimica et Biophysica Acta - BiomembranesThe 97-residue influenza A matrix 2 (ΑM2) protein, a prototype for viroporins, transports protons through water molecules and His37. We discuss structural biology and molecular biophysics experiments and some functional assays that have transformed over ...
Kyriakos Georgiou, A. Kolocouris
semanticscholar +1 more source
Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome
PLoS Pathogens, 2012 Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome. Recent studies have
Minako Ito +2 more
openaire +4 more sources
The Viroporin Activity of VP2, VP3 and VP4 Contribute to the SV40 Viral Life Cycle
, 2012 Viruses have evolved to exploit cellular pathways and machinery in order to deliver their genome to the cell, replicate, and produce viral progeny. Nonenveloped viruses must overcome membrane barriers to infect host cells and trigger lysis for virion ...
Giorda, Kristina M
core +1 more source
Molecular SimulationVaccine technology enabled the rapid development and approval of COVID-19 vaccines, whereas antiviral treatments for SARS-CoV-2 often rely on existing drugs.
Jorge Samuel León-Magdaleno +2 more
semanticscholar +1 more source
Investigation of Molecular Mechanism of JC virus Viroporin Activity
Uirusu, 2015 Viroporins are small and hydrophobic viral proteins that form pores on host cell membranes, and their expression can increase the permeability of cellular membranes and the production of progeny virus particles. JC virus (JCV) is the causative agent of progressive multifocal leukoenchephalopathy (PML).
openaire +3 more sources
A WEEV 6K viroporin activates MLKL-dependent necroptosis to drive inflammatory injury
Cell Death DiscoveryNeurotropic alphavirus infection is characterized by neuronal injury and sustained neuroinflammation, yet the viral determinants linking membrane perturbation to host inflammatory damage remain poorly defined.
Zi-Yan Zhou +3 more
semanticscholar +1 more source
Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein-3
, 2011 Copyright information:Taken from "Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein"http://www.virologyj.com/content/4/1/123Virology Journal 2007;4():123-123.Published online 20 Nov 2007PMCID:PMC2211469 ...
Joshua M Costin (38040) +3 more
core +1 more source
Computational electrophysiology simulation study of the Dengue virus viroporins
Journal of Biomolecular Structure and DynamicsDengue virus, an arbovirus belongs to the Flavivirus genus is the causative agent of Dengue fever, Dengue Hemorrhagic fever and Dengue Shock Syndrome, and accounts for thousands of lives every year. Here, we have characterized three such Dengue virus proteins (NS2A, NS2B and M) which have been previously shown to possess porin like functions.
Dwaipayan Chaudhuri +2 more
openaire +2 more sources