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NS2A comprises a putative viroporin of Dengue virus 2 [PDF]
Virulence, 2017 During infection with Dengue virus (DENV), host cells undergo a series of detrimental functional changes, including profound remodelling and redistribution of cell membrane structures,1,4 which giv...
Gaurav Shrivastava +2 more
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Viroporin activity of murine hepatitis virus E protein [PDF]
FEBS Letters, 2005 The viroporin activity of the E protein from murine hepatitis virus (MHV), a member of the coronaviruses, was analyzed. Viroporins are a growing family of viral proteins able to enhance membrane permeability, promoting virus budding. Initially, the MHV E gene was inducibly expressed in Escherichia coli cells, leading to the arrest of bacterial growth ...
MIGUEL Angel Sanz, Luis Carrasco
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[The antiviral targeting potential of viroporins].
Ugeskrift for laeger, 2022Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine.
John D, Sund +9 more
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Functional and Structural Characterization of 2B Viroporin Membranolytic Domains
Biochemistry, 2008Nonstructural 2B viroporin is an intracellularly produced pore-forming protein required for effective enteroviral and rhinoviral replication. The sequence of 2B displays two putative interconnected transmembrane domains, which are predicted to insert into the negatively charged membranes of target organelles forming an integral hairpin.
Silvia, Sánchez-Martínez +5 more
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SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway
Virology, 2022Huanzhou Xu +2 more
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