Results 111 to 120 of about 4,200 (198)
A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel
The FEBS Journal, Volume 292, Issue 13, Page 3378-3396, July 2025.A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang +5 more
wiley +1 more source
The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel
, 2017 Viroporins are small virus-encoded ion channel proteins. Most viroporins are monovalent selective cation channels, with few showing the ability to conduct divalent cations, like calcium (Ca2+). Nevertheless, some viroporins are known to disrupt host cell
Anne H. Delcour +4 more
core +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions [PDF]
, 2020 Classic swine fever is a highly contagious and often fatal viral disease that is caused by the classical swine fever virus (CSFV). Protein p7 of CFSV is a prototype of viroporin, a family of small, highly hydrophobic proteins postulated to modulate virus-
Carravilla, Pablo +7 more
core +1 more source
Viroporins and inflammasomes: A key to understand virus-induced inflammation
The International Journal of Biochemistry & Cell Biology, 2020 Viroporins are virus encoded proteins that alter membrane permeability and can trigger subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a hydrophilic pore which facilitates ion transport across host cell membranes.
Farag, N.S. +3 more
openaire +2 more sources
Viruses, 2015 Viroporins are small hydrophobic viral proteins that oligomerize to form aqueous pores on cellular membranes. Studies in recent years have demonstrated that viroporins serve important functions during virus replication and contribute to viral ...
To Sing Fung +2 more
doaj +1 more source
Transcription Kinetics in the Coronavirus Life Cycle
WIREs RNA, Volume 16, Issue 1, January/February 2025.The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko +2 more
wiley +1 more source
Frontiers in Chemistry, 2018 Chronic hepatitis C is characterized by metabolic disorders and by a microenvironment in the liver dominated by oxidative stress, inflammation and regeneration processes that can in the long term lead to liver cirrhosis and hepatocellular carcinoma ...
Rosella Scrima +3 more
doaj +1 more source
Plum pox virus: An overview of the potyvirus behind sharka, a harmful stone fruit disease
Annals of Applied Biology, Volume 186, Issue 1, Page 49-75, January 2025.Plum pox virus is a member of the genus Potyvirus in the family Potyviridae. The significance of this virus is underscored by its large strain diversity, wide host range, broad geographical distribution and the great socio‐economic impact of sharka, the disease it causes. Abstract The study of Potyvirus plumpoxi (plum pox virus, PPV) has a long history,
Juan Antonio García +5 more
wiley +1 more source
The Interplay Between Viral Infection and Cell Death: A Ping‐Pong Effect
Advances in Virology, Volume 2025, Issue 1, 2025.Programmed cell death (PCD) is a well‐studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival.
Alireza Nourazarian +5 more
wiley +1 more source