Results 61 to 70 of about 4,200 (198)
Viroporins: structure, function and potential as antiviral targets [PDF]
Journal of General Virology, 2015 The channel-forming activity of a family of small, hydrophobic integral membrane proteins termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and DNA viruses, generating significant interest in targeting these proteins for antiviral development.
Scott, C, Griffin, S
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Zika virus M protein as a viroporin drug target [PDF]
, 2020 Zika virus (ZIKV) an arbovirus that became widely known in 2015 due to the epidemic in Brazil, spreading across South and North America. Whilst previous Old World ZIKV outbreaks comprised largely mild, or even asymptomatic infections, the New World ...
Brown, Emma Tabitha
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Viruses, 2021 ORF3a has been identified as a viroporin of SARS-CoV-2 and is known to be involved in various pathophysiological activities including disturbance of cellular calcium homeostasis, inflammasome activation, apoptosis induction and disruption of autophagy ...
Tyng Hwey Tan +5 more
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Biomolecules, 2022 Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and
Han-Gang Yu +3 more
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Viruses, 2019 Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with ...
Zengbin Li +4 more
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eLife, 2020 Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw +21 more
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The minimalist architectures of viroporins and their therapeutic implications
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity.
OuYang, Bo, Chou, James J.
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Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-like Superfamilies [PDF]
, 2023 Viroporins are small multifunctional proteins that modify cellular membranes to facilitate viral infections such as viral nucleic acid entry and the release of virions from infected cells.
Wang, Jianing
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Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif
Viruses, 2015 Filoviruses, such as Ebola and Marburg viruses, cause severe outbreaks of human infection, including the extensive epidemic of Ebola virus disease (EVD) in West Africa in 2014. In the course of examining mutations in the glycoprotein gene associated with
William R. Gallaher, Robert F. Garry
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Impact of histidine residues on the transmembrane helices of viroporins [PDF]
Molecular Membrane Biology, 2013 Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small membrane proteins that exhibit ion channel activity, and have a single TM helix that is capable of forming oligomers.
Wang, Yan +3 more
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