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Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity. [PDF]
VirusesViruses have a wide repertoire of molecular strategies that focus on their replication or the facilitation of different stages of the viral cycle. One of these strategies is mediated by the activity of viroporins, which are multifunctional viral proteins that, upon oligomerization, exhibit ion channel properties with mild ion selectivity.
Cedillo-Barrón L +3 more
europepmc +4 more sources
Recent developments in antiviral agents against enterovirus 71 infection [PDF]
, 2014 Enterovirus 71 (EV-71) is the main etiological agent of hand, foot and mouth disease (HFMD). Recent EV-71 outbreaks in Asia-Pacific were not limited to mild HFMD, but were associated with severe neurological complications such as aseptic meningitis and ...
Chee Tan +3 more
core +1 more source
Viroporins from RNA viruses induce caspase-dependent apoptosis [PDF]
Cellular Microbiology, 2007 The virus-encoded viroporins are known to modify membrane permeability and play an essential role in virus budding. Here, a comparative analysis of the membrane permeabilization capacity of a number of viroporins was performed in baby hamster kidney cells.
Vanessa, Madan +2 more
openaire +2 more sources
The Interplay of Reovirus with Autophagy [PDF]
, 2014 Autophagy participates in multiple fundamental physiological processes, including survival, differentiation, development, and cellular homeostasis. It eliminates cytoplasmic protein aggregates and damaged organelles by triggering a series of events ...
Chiu, Hung-Chuan +4 more
core +7 more sources
Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]
DNA and Cell Biology, 2013 Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire +2 more sources
The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2 [PDF]
, 2013 10.1016/j.virusres.2012.12.005Virus Research 1721-224 ...
Aweya, Jude Juventus +3 more
core +1 more source
Unusual architecture of the p7 channel from hepatitis C virus [PDF]
, 2014 The Hepatitis C virus (HCV) has developed a small membrane protein, p7, which remarkably can self-assemble into a large channel complex that selectively conducts cations1-4.
Berardi, Marcelo J. +7 more
core +1 more source
Molecules, 2020 The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an ...
Maggie C. Duncan +12 more
doaj +1 more source
Calicivirus Non-structural Proteins: Potential Functions in Replication and Host Cell Manipulation
Frontiers in Microbiology, 2021 The Caliciviridae are a family of viruses with a single-stranded, non-segmented RNA genome of positive polarity. The ongoing discovery of caliciviruses has increased the number of genera in this family to 11 (Norovirus, Nebovirus, Sapovirus, Lagovirus ...
Elena Smertina +8 more
doaj +1 more source
Blocking Zika virus vertical transmission. [PDF]
, 2018 The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB +23 more
core +2 more sources