Results 61 to 70 of about 3,182 (158)
Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Frontiers in Microbiology, 2019 Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate
I-Yin Chen +3 more
doaj +1 more source
iNew Medicine, Volume 2, Issue 2, June 2026.This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng +3 more
wiley +1 more source
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5
MedComm, Volume 7, Issue 6, June 2026.The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie +9 more
wiley +1 more source
The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba +4 more
wiley +1 more source
Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV
Viruses, 2016 The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The transmembrane domain of the protein has dual functions: it counteracts the human restriction factor ...
Timo Greiner +7 more
doaj +1 more source
The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin
Protein Science, Volume 35, Issue 2, February 2026.Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola +6 more
wiley +1 more source
Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses
Journal of Inflammation Research, 2021 SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture ...
Choudhury SM, Ma X, Abdullah SW, Zheng H
doaj
Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.Objective Pulmonary fibrosis may develop in patients with severe clinical conditions, especially those with high inflammatory indicators. We aimed to investigate the 15‐month follow‐up clinical outcomes in patients with moderate‐to‐severe COVID‐19 pneumonia treated with colchicine and to evaluate its potential in preventing post‐COVID pulmonary ...
Gulhan Ayhan Albayrak +3 more
wiley +1 more source
Viroporins Customize Host Cells for Efficient Viral Propagation [PDF]
DNA and Cell Biology, 2013 Viruses are intracellular parasites that must access the host cell machinery to propagate. Viruses hijack the host cell machinery to help with entry, replication, packaging, and release of progeny to infect new cells. To carry out these diverse functions, viruses often transform the cellular environment using viroporins, a growing class of viral ...
Kristina M, Giorda, Daniel N, Hebert
openaire +2 more sources
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.The type I interferon (IFN‐I) signaling pathway plays a pivotal role in orchestrating antiviral innate immune defenses, particularly during the clearance of invading pathogens. Rotaviruses have evolved a repertoire of viral proteins to counteract host immune surveillance. While certain functions of rotavirus nonstructural proteins in antagonizing IFN‐I
Jiaxing Zhan +12 more
wiley +1 more source